Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0024530 (
malaria
)
44,886
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Malaria
, the disease caused by
Plasmodium
spp. infection, remains a major global cause of morbidity and mortality. Host protection from
malaria
relies on immune-driven resistance mechanisms that kill
Plasmodium
However, these mechanisms are not sufficient per se to avoid the development of severe forms of disease. This is accomplished instead via the establishment of disease tolerance to
malaria
, a defense strategy that does not target
Plasmodium
directly. Here we demonstrate that the establishment of disease tolerance to
malaria
relies on a tissue damage-control mechanism that operates specifically in renal proximal tubule epithelial cells (RPTEC). This protective response relies on the induction of heme oxygenase-1 (
HMOX1
; HO-1) and ferritin H chain (
FTH
) via a mechanism that involves the transcription-factor nuclear-factor E2-related factor-2 (
NRF2
). As it accumulates in plasma and urine during the blood stage of
Plasmodium
infection, labile heme is detoxified in RPTEC by HO-1 and
FTH
, preventing the development of acute kidney injury, a clinical hallmark of severe
malaria
.
...
PMID:Renal control of disease tolerance to malaria. 3083 8
