Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0024530 (
malaria
)
44,886
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Hyperreactive malarious splenomegaly is an aberrant response to chronic malarial infection, defined by persistent gross splenomegaly and elevated serum IgM and IgG. The populational and familial patterns of this disorder suggest genetically based, immune incompetence. In Papua New Guinea, the disease occurs among populations characterized by high frequencies of
IGHG3
G haplotypes. Elsewhere, the distribution and prevalence of hyperreactive malarious splenomegaly is consistent with the distributions of
IGHG3
alleles. Drawing upon this relationship, I suggest that expression of the G3M G phenotype is a necessary precondition for hyperreactive malarious splenomegaly, consistent with the pathogenesis of
malaria
and the functions of the immune system.
...
PMID:IGHG3 G and the pathogenesis of hyperreactive malarious splenomegaly. 869 37
