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Query: UMLS:C0024530 (malaria)
 44,886 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Genetic factors have been suggested as having a possible aetiological role in the incidence of carcinoma of the cervix. With the high frequency of carcinoma of the cervix in Ibadan as well as the high incidence of sickle-cell trait, the haemoglobin genotypes and ABO blood groups were analysed in patients managed for carcinoma of the cervix uteri in the University College Hospital, Ibadan. No significant association was found between any haemoglobin genotype or blood group and carcinoma of the cervix. The protection afforded against malaria by the haemoglobin S trait does not seem to protect against the development of invasive carcinoma of the cervix.
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PMID:Haemoglobin genotype, ABO blood groups and carcinoma of the cervix. 59 60

Discrepancies between malaria inoculation rates measured entomologically and parasitologically may be explained, at least in part, if infants and children receive less mosquito bites per night than do adults. We found that this problem could be studied by choosing women and children of different ABO blood groups. In preliminary laboratory studies it was found that the blood group of a mosquito's blood meal could be determined in parous and nulliparous mosquitoes for at least 24 hours, and, nullipares up to 34 hours, after feeding. An antiserum against the O group was necessary to distinguish non A or B red cells from those of animal origin. Cross reactions did occur, presumably as a result of the digestion by mosquitoes of the red cell surfaces, but in every case the strongest and earliest developing agglutination was that of the host. Field studies were made using women and children sleeping under mosquito nets, the holes in which made the nets a trapping device. The women, on average, received over seven times more bites per night than did the children. The migration of blood-fed mosquitoes from one net to another was negligible.
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PMID:The use of ABO blood groups as markers for mosquito biting studies. 70 42

Subjects from Muria gond tribal community (n = 258) as well as from Delhi (n = 100) were classified according to ABO blood groups, and were also assayed for malarial antibodies by ELISA technique. The distribution of ABO blood groups did not differ significantly in Muria gonds and Delhi subjects. Within Muria gonds the observed frequency of ABO blood groups did not differ significantly from the expected values. No significant difference was observed in the rate of seropositivity for malarial antibodies among subjects with different blood groups. Malarial parasitaemia, although observed more in individuals with blood group A, did not differ significantly as compared with other blood groups. We conclude that ABO blood groups do not show differential susceptibility to malaria.
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PMID:Malaria and ABO blood groups. 129 45

783 blood samples for the study of distribution of ABO blood groups and sickle cell haemoglobin in relation to malaria, from both the sexes of Muslim and Christian populations of Kheda district were screened. 414 blood samples from male individuals were screened for G-6-PD deficiency. High frequency of G-6-PD deficiency was observed in Christians (5.9%) and low in Muslim (1.8%) population, whereas sickle cell haemoglobin in Muslim population was 1.5% and absent in Christians. Blood group B was dominant in both the communities. Significant association of ABO polymorphs with P. falciparum and total malaria cases was observed.
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PMID:An epidemiological study of G-6-PD deficiency, sickle cell haemoglobin, and ABO blood groups in relation to malaria incidence in Muslim and Christian communities of Kheda, Gujarat, (India). 134 53

Malaria 'susceptible' and 'refractory' subjects from village Bhanera in District Ghaziabad (Uttar Pradesh) were examined for various genetic markers, viz., ABO, haptoglobin, haemoglobin and glucose-6-phosphate dehydrogenase polymorphism. One hundred and nine susceptible and 36 refractory subjects were studied. No significant differences with respect to distribution patterns of the genetic markers were observed in the two groups except for AB blood group. In general, a high incidence of ahaptoglobinaemia was observed in this population and incidence increased with the increase in malaria attacks, suggesting that repeated malaria attacks cause ahaptoglobinaemia.
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PMID:Genetic markers in refractory and susceptible malaria patients in village Bhanera, Distt. Ghaziabad, U.P. 182 53

Adults claiming resistance to malaria were identified in the Sennar region of central Sudan, where P. falciparum is hyperendemic but seasonal in transmission. Indirect fluorescent antibody (IFA) titers of sera from these individuals were comparable to those of malaria patients with positive blood films, indicating equal exposure, while in vitro antiparasitic activity of their sera tended to be higher, indicating an effective immunological response to falciparum malaria. Hemoglobin S (Hb S) was significantly more prevalent in adults resistant to malaria. This trait offers protection at the erythrocyte level and it is also possible that it could enhance the ability of carrier adults to acquire protective immunity. Erythrocyte 6-phosphogluconate dehydrogenase A (PGDA) and phosphoglucomutase 1 (PGM1), phenotypes of unknown relevance to protection against falciparum malaria, were also significantly more prevalent in those claiming resistance to malaria. A trend of higher prevalence for erythrocyte glucose-6-phosphate dehydrogenase deficiency (G6PD-), Kell (+) and transferrin D (TfD) was detected among resistant individuals and higher KP(a+) and P2 among malaria patients, but the numbers evaluated in this study did not allow determination of statistical significance. No association was found with erythrocyte glyoxalases, ABO and Duffy blood groups and serum haptoglobins.
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PMID:Resistance to falciparum malaria among adults in central Sudan. 293 61

189 healthy controls and 175 patients suffering from malaria vivax have been investigated with regard to associations between this disease and 22 genetic polymorphisms of the blood (ABO, MN, Ss, Rh, Kell, P, Lutheran, Kidd, Duffy, Diego, Xg; ABH-Secretor; Hp, Gc, Gm, Km; aP, AK, PGM1, 6-PGD, EsD; Hb variants) Significant associations could be demonstrated only for P and Hp systems, though in accordance with other investigations it cannot be excluded that the ABO system plays also a role in this connection.
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PMID:Genetic markers and malaria. Observations in Gujarat, India. 351 22

Malaria is uncommonly acquired without mosquito transmission. Two patients presenting with malaria illustrate this rare phenomenon. The first was a 1-month-old child who had received an exchange blood transfusion for severe haemolytic anaemia due to ABO blood incompatibility. The second was a doctor who had taken blood from the first patient. The occurrence of both transfusion malaria and accidental malaria from the same blood transfusion must be very uncommon.
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PMID:Unusual forms of malaria transmission. A report of 2 cases. 354 51

We sought to determine if there was any relationship between ABO blood groups and susceptibility to malaria and urinary schistosomiasis. In Epe and outlying villages in south-western Nigeria, we examined 681 people for their blood groups, malaria parasitemia and for the presence of Schistosoma haematobium eggs in their urine specimens. Two hundred and sixty-nine individuals were parasitemic for falciparum malaria, 97 subjects had urinary schistosomiasis and 56 people carried concurrent infections of both parasites. Frequencies of the blood groups were 56.68% for group 0, 22.32% for group B, 18.5% for group A and 2.50% for the AB group. The rates of infection with malaria and/or schistosomiasis showed no significant association with the frequencies of the ABO blood groups.
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PMID:ABO blood groups in malaria and schistosomiasis haematobium. 612

Genetic markers have recently been found to be much more polymorphic than expected. Such extensive human polymorphisms may be partly explained by a number of genetic and environmental factors, including infectious diseases. Malaria, which was very widespread in the past and still poses a problem in many countries today, is a good candidate for research. The association between malaria and glucose-6-phosphate dehydrogenase (G6PD) deficiency is well-known, but more should be done to determine the mechanisms responsible for this positive correlation and to confirm that malaria is a strong selective factor for many other genotypes also. The present paper refers to a WHO project on genetic markers and susceptibility to infectious diseases, which is concerned mainly with G6PD deficiency and the following genetic markers: haemoglobinopathies, including the beta-thalassaemia trait and ABO, Rh, MN, Duffy, secretory types (Ss), and human leukocyte antigens (HLA). Since malaria was eradicated in Bulgaria many years ago, human populations from this country, living at different altitudes above sea-level, were used as a model for analysis of the malaria hypothesis. The data for G6PD deficiency confirm that malaria was a selective factor in lowland areas where malaria infection was more frequent in the past. It is, moreover, apparent that in addition to malaria some other factors also play a selective role.
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PMID:Frequency of glucose-6-phosphate dehydrogenase deficiency in relation to altitude: a malaria hypothesis. 696 37


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