Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0024530 (malaria)
 44,886 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Facial scarification is a process of engraving marks on selected portions of the face at infanthood for various cultural purposes. It is a common cultural practice in Africa especially Nigeria. The induction is associated with fever and severe crying in infants. Usage of the same unsterile tools for the induction in different children and the unhygienic environment are possible means of contracting HIV infection. Occurence of G-6-P-D deficiency and malaria predipose to severe anaemia often requiring blood transfusion. Blood screening facilities are grossly lacking in most rural areas in developing countries. This report is on a 2-year-old male child who presented with facial marks, lacked G-6-P-D and died of HIV infection after a follow-up of 6 months. We suggest that HIV infection contracted from facial scarification in the presence of G-6-P-D deficiency caused the child's death.
 ...
PMID:Death of a G-6-P-D deficient child with co-morbid HIV infection linked to scarification. 1720 25

The main objective was to investigate the effects of ABO/Rh blood groups, haemoglobin genotype and G-6-P-D enzyme activity on malaria. The study was carried out in Buea, South West Province, Cameroon. Subjects consulting at health care facilities in Buea were randomly recruited into the study. A total of 121 febrile patients 1-60 years old comprised the study subjects. Thin and thick blood films were prepared for malaria parasite detection. G-6-P-D enzyme activity was assayed using the met-haemoglobin reduction test. Determination of haemoglobin genotypes was by a rapid screening method alongside electrophoresis. Malaria positive patients were treated. The highest malaria prevalence of 74.5 % was in Group O individuals and the lowest of 58.6% in group B individuals. Mean parasite density (Log(10)(-1)/ul blood) in the various blood groups was not significantly different. Individuals with G-6-P-D deficiency had a significantly lower malaria prevalence (47.5%) when compared with active individuals. Mean parasite density in enzyme deficient and active individuals was 3.7(SD+/- 3.9) and 4.4(SD +/-5.0) respectively and the difference was significant (p < 0.05). Malaria prevalence was lower (57.5%) in HbS individuals when compared with HbAA (74.6%) and HbSS (60%) but parasite density was not significantly different. Our results suggest that individuals with blood group O who have the HbAA genotype and show G-6-P-D enzyme activity may be more susceptible to malaria. Information on the influence of these genetic factors on malaria would be useful in the better management of the disease in the study area.
 ...
PMID:Effects of ABO/Rh blood groups, G-6-P-D enzyme activity and haemoglobin genotypes on malaria parasitaemia and parasite density. 1729 25