Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0024530 (malaria)
 44,886 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Trypanosoma musculi brought into Plasmodium berghei-infected mice in the later stages of the malaria infection shows rapid, approximately logarithmic multiplication in the peripheral blood. The trypanosome number increases by a factor of 2-9 per day, multiplication of the parasites kills most mice in a few days. Many multiplicative forms of the trypanosomes and a few trypanosomes without nuclei are seen in blood smears. Histologically and in touch preparations, masses of multiplicative forms of the trypanosomes are seen in the sinusoids of the liver. Aggregates of trypanosomes are found, too, in the kidney medulla and, inconstantly, in venous sinuses of the spleen and postcapillary venules of lymph nodes. Occasionally, trypanosomes may be found extravascularly in the interstitial connective tissue especially of the pancreas, in lymph vessels and lymph node sinuses. - Mice infected in earlier stages of the Plasmodium berghei infection achieve stabilization of trypanosome numbers.
Tropenmed Parasitol 1975 Sep
PMID:[Course of Trypanosoma musculi infections in Plasmodium berghi-infected mice (author's transl)]. 110 89

Eleven narcotic injectors from a prison in Saigon were hospitalized with falciparum malaria. Coma and intense parasitemia were common and eight patients died soon after admission. Two of three autopsied cases also had purulent pulmonary infections. No non-addicted prisoners were hospitalized for malaria. Nine more unsuspected falciparum infections were found among 29 other addicts in the prison. The clustering of malaria infections among narcotic injectors who had not been in malarious areas indicates that the malaria was transmitted by the common use of needles and syringes. Cerebral malaria in an addict may be misdiagnosed as drug intoxication. Malaria surveillance is recommended for the increasing addict population in the cities of Southeast Asia.
Am J Trop Med Hyg 1975 Sep
PMID:Fatal falciparum malaria among narcotic injectors. 110 39

Acetylator phenotype was determined in 33 volunteers who were infected with a chloroquine-resistant strain of Plasmodium falciparum and who received, for cure, 2 g of sulfalene and 50 mg of pyrimethamine. This drug combination did not cure 5 of 14 rapid acetylators and 3 of 19 slow acetylators. This difference is not significant. Plasma levels of non-acetylated sulfalene, acetylated sulfalene, acetylation, and biologic half-life of non-acetylated sulfalene after administration of the combination did not differ importantly between the two groups. Acetylator phenotype does not appear to influence the response to sulfalene and pyrimethamine of individuals infected with chloroquine-resistant falciparum malaria.
Am J Trop Med Hyg 1975 Sep
PMID:Acetylator phenotype and response of individuals infected with a chloroquine-resistant strain of Plasmodium falciparum to sulfalene and pyrimethamine. 110 40

The complement fixation (CF), indirect immunofluorescence (IIF), and indirect hemagglutination (IHA)tests for malaria were compared by using sera from U.S. citizens with either natural infections or heroin-associated, needle-induced infections. In natural Plasmodium vivax infections, the CF, IIF, and IHA tests apparently detect malarial antibodies equally efficiently for the first 2 months after the onset of symptoms, but the titers obtained by CF and IIF rapidly decline within a year, while the IHA titers remain elevated. In the sera from heroin addicts who developed needle-induced P. vivax infections, sensitivities of all three tests were decreased: the IIF and IHA tests each detected 83%, but the CF test detected only 57.1%. False-positive reactions with this group were very high for the CF (76.6%) and IHA (15.9%) tests, but only 2% for IIF.
Am J Trop Med Hyg 1975 Sep
PMID:Comparison of the complement fixation, indirect immunofluorescence, and indirect hemagglutination tests for malaria. 110 41

The effect of lowered host-environmental temperature upon the development and maturation of the preerythrocytic tissue stages of rodent malaria parasites has been investigated in two strains of Plasmodium berghei originating from the highlands of Katanga. Young albino rats inoculated with massive sporozoite doses of P. berghei NK 65 and maintained for 48 hours at 12 degrees C developed small, stunted tissue schizonts, averaging 11 X 15 microns, of a distinct morphology. Control rats kept at room temperature of 27 degrees C showed mature tissue schizonts of normal growth averaging 24 X 29 microns. Blood from the rats kept at lower temperature for 48 to 50 hours failed to produce parasitemia when inoculated into susceptible recipient mice. All the mice given blood from control rats developed parasitemia. However, when sporozite-inoculated rats were kept for 96 hours or longer at 12 degrees C they developed parasitemia and their liver showed maturation of 10% of the preerythrocytic schizonts. Experiments with the ANKA strain of P. berghei did not show significant differences in size and morphology between parasites in rats kept for 46.5 hours at 9 degrees C and 12 degrees C and those in controls kept at 20 degrees C. However, subinoculation of blood from the low temperature experimental groups into recipient mice at 46.5 hours after intravenous sporozoite inoculation failed to produce parasitemia, whereas all the recipient mice from the control groups developed parasitemia in 4 or 5 days. The findings are discussed in the light of the evolution of plasmodia and the phenomena of relapse and delayed primary attack in certain malaria infections.
Am J Trop Med Hyg 1975 Sep
PMID:Effects of lowered environmental temperature on the growth of exoerythrocytic stages of Plasmodium berghei. 110 42

The frequency of PC allele for acid phosphatase in fourteen Sardinian villages correlates positively with the altitude and negatively with past malarial morbidity and GdMed prevalence. The susceptibility towards hemolytic favism in Sardinian males with G6PD deficiency is dependent on the erythrocyte acid phosphatase and thalassemia phenotypes. Thalassemia trait exerts a protective action only in subjects carrying PA allele for acid phosphatase. The data suggest that the gradient for malaria morbidity directly or indirectly, through interactions with thalassemia and G6PD polymorphisms, mediated by the habit of eating Vecia faba, may have had a significant role in determining the heterogeneous distribution of acid phosphatase polymorphism in Sardinia. Besides malaria, other environmental factors related with altitude seem to have been very important in shaping the present pattern of distribution of both acid phosphatase and G6PD polymorphisms in Sardinia.
Am J Phys Anthropol 1975 Sep
PMID:Red cell acid phosphatase: another polymorphism correlated with Malaria? 118 Mar 55

Chloroquine in a concentration range from 5 ng to 2 mug per ml of biological fluid can be determined in plasma and urine by the spectrofluorometric methods. The spectrodensitometric method is less sensitive and should be used when other drugs are interfering with the chloroquine determination in solution. After extraction from urine and separation from interfering drugs and metabolites by TL-chromatography chloroquine can be determined by spectrodensitometry in a minimum concentration of 5 mug per ml of urine. Chloroquine should be determined in plasma and urine of patients suffering from malaria with an impaired renal function. Whether the fluorometric determination of chloroquine should be used in field investigations will depend on the problem to be investigated and the regional facilities.
Tropenmed Parasitol 1975 Sep
PMID:Spectrofluorometric and spectrodensitometric determination of chloroquine in plasma and urine. 118 23

Autoradiography was used to study the incorporation of tritium-labelled nucleic acid precursors into the sporogonic stages of Plasmodium cynomolgi in Anopheles b. balabacensis. Infected mosquitoes were fed on either 3H-adenine (5, 25 and 50 muCi/ml or 3H-thymidine (50 muCi/ml) for various periods after the blood meal. 3H-adenine was incorporated into DNA and RNA of the developing oocysts and the resulting sporozoites. Midgut epithelial cells incorporated label from 3H-adenine into nuclear and cytoplasmic regions. In both parasite and host tissue RNA-label was removed after RNase treatment. 3H-thymidine was not taken up by the developing oocysts or sporozoites while incorporation into the cell nuclei of the adjacent midgut epithelium and fat-body of the mosquito was shown. The observed incorporation of 3H-adenine, but not 3H-thymidine, into the sporogonic stages of Plasmodium supports the assumption that the malaria parasite needs exogenous sources of purine but relies on the de novo synthesis of pyrimidine during its development in the mosquito.
Tropenmed Parasitol 1975 Sep
PMID:Incorporation of nucleic acid precursors by Plasmodium cynomolgi in Anopheles balabacensis. 118 24

Serologic profiles were established using the indirect fluorescent antibody test in a longitudinal study of six villages in an interior area of El Salvador. Positive serologic responses as well as active cases found through the voluntary collaborator posts occurred primarily in adult males, suggesting that much of the malaria experience in the study area resulted from exposure of this segment of the population in more malarious areas where they traveled to engage in temporary agricultural labor. Malaria incidence was generally low but transmission potential apparently varied markedly even over relatively small distances. Serologic profiles reflected the malaria experience in the population sampled, but many localities were widely dispersed and samples taken from village centers were found in some cases not to be representative of the entire locality population in terms of malaria exposure. The indirect fluorescent antibody technique was found to reflect the malaria experience in the population segments examined. When these data were correlated with the surveillance data from the voluntary collaborator posts, the epidemiology of malaria in the study area was more thoroughly understood.
Am J Trop Med Hyg 1975 Sep
PMID:The seroepidemiology of malaria in Middle America. I. Longitudinal studies on populations in a low incidence area of El Salvador. 119 Mar 63

Serologic studies for malaria using the indirect fluorescent antibody technique suggest that active transmission is either absent or very low in 6 villages on the Pacific side of Costa Rica. Positive titers (1:20 or higher) were seen in the under-15-year age group in three of the study localities, but only 5 such responses were encountered among 249 people examined in this age range. In the adults (15 years and over) from the same 3 villages there were 68 positive titers among 161 examined. There were 43 positive responses in 189 adults from the remaining 3 villages where none of 307 persons under 15 years of age showed a titer of 1:20 or higher to any of the 3 malaria antigens tested (Plasmodium falciparum, P. vivax and P. malariae). These data suggest that the positive responses in the latter villages are more likely to be associated with old or imported cases than with current local transmission. Serologic responses of 1:80 or higher to the P. falciparum antigen suggested the continued presence of this parasite in the population in spite of the paucity of positive blood smears with this species in recent years. Positive titers with the P. malariae antigen suggest that this parasite is probably still present in the area. Such serologic studies help to indicate areas where malaria transmission is active and provide information on parasite reservoirs in particular populations.
Am J Trop Med Hyg 1975 Sep
PMID:The seroepidemiology of malaria in Middle America. II. Studies on the Pacific coast of Costa Rica. 119 Mar 64


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>