Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0024530 (malaria)
 44,886 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The chloroquine sensitivity of Plasmodium falciparum was studied in two areas of Sudan. In the Gezira, 99.2% of the patients tested responded completely to the drug. Two patients (0.4%) and one patient (0.2%) showed, respectively, RI and RII responses. However, in those showing RI response reinfection could not be excluded. In an area of southern Sudan patients could only be followed-up for 7 days; nevertheless, this was sufficient to exclude the presence of RII and RIII responses there. This study also showed that malaria is a common cause of fever in Sudan, as over 90% of fever cases tested in the Gezira were positive for malaria and P. falciparum was the predominant species in these cases.
Am J Trop Med Hyg 1978 Sep
PMID:Response of Plasmodium falciparum in Sudan to oral chloroquine. 36 53

A survey in northern and southern Sudan showed that Plasmodium falciparum is the predominant species in malaria cases, occurring in 91% and 87%, respectively of the positive cases in these two regions. P. ovale was extremely rare in southern Sudan and was absent in the north. The survey, which was carried out during the transmission season in northern Sudan, showed that malaria is common, occurring in 62% of those tested in some villages. A trial of mass chemoprophylaxis resulted in a marked decline in prevalence after 1 year, demonstrating the importance of chloroquine and establishing that malarial parasites in Sudan are highly sensitive to the drug.
Am J Trop Med Hyg 1978 Sep
PMID:Species prevalence of malaria in northern and southern Sudan, and control by mass chemoprophylaxis. 36 54

A total of 49 semi-immune Laotians aged 3 to 49 years, with falciparum malaria were treated with a single dose of sulfadoxine pyrimethamine (1500 mg, 75 mg, adult dose), in Vientiane, Laos. On day 7 after treatment the 49 cases were asymptomatic with complete disappearance of patent asexual parasitaemia. The result is compared with that obtained from treating 48 similar cases with a standard dose of chloroquine over 3 days.
Southeast Asian J Trop Med Public Health 1978 Sep
PMID:Clearance of falciparum parasitaemia with a single dose sulfadoxine-pyrimethamine in Vientiane, Laos. 37 31

Liposomes containing neutral glycolipids with a terminal glucose or galactose, when injected intravenously, prevented the appearance of erythrocytic forms of malaria (Plasmodium berghei) in mice previously injected with sporozoites. Inhibitory glycolipids included glucosyl, galactosyl, or lactosyl ceramide. Inhibition was not observed with liposomes containing ceramide, phosphocholine ceramide, sulfogalactosyl ceramide (sulfatide), or ganglioside GM1. Liposomes containing glycolipids did not inhibit infection transmitted by injecting blood containing erythrocytic stages of malaria. These results may have therapeutic implications in the treatment of malaria. Analysis of the mechanism of interference with the life cycle of malaria by liposomal glycolipids may yield information about the interactions of parasites with cellular membranes.
Science 1979 Sep 14
PMID:Sporozoite-induced malaria: therapeutic effects of glycolipids in liposomes. 38 58

The host cell competence of hemoglobin C (HbC)-containing erythrocytes for Plasmodium falciparum was studied by in vitro culture. HbC homozygous red cells did not support the growth of the intracellular parasite. Heterozygous cells, however, were competent. In addition, HbC increased the resistance of sicle cell hemoglobin (HbS) red cells when present in the double heterozygote, SC, cultured at low oxygen tension. This effect most likely resulted from the ability of HbC to enhance the sickling of HbS-containing red cells. Oxygenated SC cells were indistinguishable from normal and AS cells in host cell competence. Another double heterozygote, SNBalt, showed decreased sickling and decreased resistance to malaria parasite growth. The evolutionary significance of these results is discussed.
Am J Trop Med Hyg 1979 Sep
PMID:The role of hemoglobins C, S, and Nbalt in the inhibition of malaria parasite development in vitro. 38 16

In April of 1977 an outbreak of falciparum malaria occurred among the Mayongong Indians, located at Uauaris in the Territory of Roraima, Brazil. Blood specimens from 157 Indians were examined for Plasmodium; 62 were found to be infected. In three cases the infection was not cured with chloroquine but responded favorably to the drug combination of sulfadoxine and pyrimethamine (Fansidar).
Am J Trop Med Hyg 1979 Sep
PMID:Drug-resistant falciparum malaria among the Mayongong Indians in the Brazilian Amazon. 38 18

A patient with cerebral malaria complicated by full-blown DIC, after failing to respond to other forms of treatment, was successfully treated by exchange transfusion. To the best of the authors' knowledge, this may be first reported case of full-blown DIC in malaria successfully treated by exchange transfusion.
Southeast Asian J Trop Med Public Health 1979 Sep
PMID:Exchange transfusion in cerebral malaria complicated by disseminated intravascular coagulation. 39 Jul 23

Primaquine (I) has been extensively used in combination with other drugs in the radical cure of relapsing malaria as well as for prophylaxis or the interruption of transmission. This, coupled with the activity data reported for 4-methylprimaquine (II), has led to the synthesis of a series of 14 4-substituted analogues of I. In addition, three side-chain analogues of II were prepared. The compounds were tested for suppressive antimalarial activity against Plasmodium berghei in the Rane mouse screen and for radical curative activity against Plasmodium cynomolgi in the rhesus monkey. Four of the 17 compounds prepared (1a, 9c, 15, and 17) exhibited activity in at least one of the test systems.
J Med Chem 1977 Sep
PMID:Antimalarials. 10. Synthesis of 4-substituted primaquine analogues as candidate antimalarials. 41 30

The ease with which malaria can be transmitted over long distances as a result of air transport is illustrated with reference to the documentary evidence. The best ways of preventing this risk are also described.
Minerva Med 1979 Sep 08
PMID:[International anti-malaria prevention today for the Italian airline]. 48 82

Main objective of this study is to determine variables related to body build and blood status of three different ethnic groups inhabiting the same locality in Northern Nigeria. Of a stratified sample of the adult male population of a village community anthropometric measurements were taken. Body build of full grown men of each of the local Fulani, Hausa and Maguzawa tribes was recorded. This included height, weight, total and muscle arm-circumference, triceps and biceps skinfolds and the determination of the Quetelet and Ponderal indices. Fulani have the same stature as Hausa and Maguzawa but they have a more linear body type, less body mass, a lesser triceps skinfold, a lower Quetelet but a higher Ponderal index. The caloric intake of the local population is considered marginally sufficient, especially for Fulani, who may have a higher energy expenditure. Malaria and Schistosoma haematobium infections are highly endemic in the area and deteriorate the nutritional state. This is more evident in Hausa and Maguzawa than in Fulani, as is a degree of anaemia probably due to iron deficiency. In the Fulani the interaction of diet and infection appears to be more complex.
Trop Geogr Med 1979 Sep
PMID:Body bulid and nutritional status of three ethnic groups inhabiting the same locality in Northern Nigeria. 52 49


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