Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0024530 (malaria)
 44,886 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Laboratory and field tests of the repellents diethyl methylbenzamide (deet), 1-(3-Cyclohexen-1-yl-carbonyl)-2-methylpiperidine (AI3-37220), and (2-hydroxymethylcyclohexyl) acetic acid lactone (CIC-4) were conducted against Anopheles dirus Peyton & Harrison, the principal malaria vector in Thailand. In the laboratory, An. dirus was more sensitive to CIC-4 than either AI3-37220 or deet. The duration of protection provided by each repellent in laboratory tests increased with higher concentrations of repellents and when exposed in cages containing fewer mosquitoes. A field study in Chanthaburi Province, southeastern Thailand, during November 1993 tested 25% (wt:wt) ethanol solutions of each repellent against An. dirus. In contrast to the laboratory experiments, protection provided by AI3-37220 was significantly better than either deet or CIC-4 and there was no significant difference between deet and CIC-4. Protection provided by deet and CIC-4 fell to below 95% 2 h after repellent application, whereas AI3-37220 provided > 95% protection for 4 h. The protection provided by all repellents fell to < or = 65% 7 h after repellent application.
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PMID:Laboratory and field evaluation of deet, CIC-4, and AI3-37220 against Anopheles dirus (Diptera: Culicidae) in Thailand. 869 42

Laboratory and field tests of the repellents diethyl methylbenzamide (deet), 1-(3-cyclohexen-1-yl-carbonyl)-2-methylpiperidine (AI3-37220), and (2-hydroxymethylcyclohexyl) acetic acid lactone (CIC-4) were conducted against Anopheles farauti s.s. Laveran, an important malaria vector in the southwest Pacific region. In the laboratory, An. farauti was tolerant of all 3 repellents, but deet and CIC-4 provided significantly better protection than AI3-37220. The field study was conducted in rain forest located near Innisfail, northern Queensland, and tested 25% (vol:vol) ethanol solutions of each repellent against An. farauti. All 3 repellents provided > 95% protection against An. farauti for 5 h after application. In contrast to the laboratory tests, protection provided by AI3-37220 was significantly better than that by either deet or CIC-4, and there was no difference between protection by deet and CIC-4. The protection by deet and CIC-4 declined 8 h after application and provided < or = 50% protection at 9 h. In contrast, AI3-37220 provided > or = 94% protection for 9 h.
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PMID:Laboratory and field evaluation of the repellents deet, CIC-4, and AI3-37220 against Anopheles farauti (Diptera: Culicidae) in Australia. 977 94

Optically inactive 1-[3-cyclohexen-1-ylcarbonyl] piperidine and 1-[3-cyclohexen-1-ylcarbonyl]-2-methylpiperidine are repellents against blood-feeding arthropods. Pure stereoisomers of these compounds were synthesized and characterized for use in bioassays. Initial laboratory tests with the malaria vector Anopheles stephensi Liston showed that this species was repelled differentially by the stereoisomers of 1-[3-cyclohexen-1-ylcarbonyl]-2-methylpiperidine. Two stereoisomers were twice as repellent as the other stereoisomers. These results indicate that stereoisomerism influences repellent efficacy in this class of compounds.
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PMID:Optically active arthropod repellents for use against disease vectors. 1521 25