Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0024530 (malaria)
 44,886 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

6 Aotus trivirgatus monkeys, which had all spontaneously recovered from an experimentally induced Plasmodium falciparum infection, were included in a clinical study concentrating on possible adverse reactions caused by a vaccine using late schizonts and merozoites as an antigen a synthetic compound, CP-20,961, as an adjuvant. Two monkeys in the study were vaccinated once, 2 twice, 1 received adjuvant alone and 1 served as a saline control. Local and general inflammatory reactions as indicated by local oedema, induration, femoral lymphadenopathy, fever and leukocytosis, were observed in all vaccinated animals and in the one monkey after the second adjuvant injection. Serum albumin and transaminase enzyme levels increased in all animals whereas plasma fibrinogen, protamine sulfate and ethanol gelation titers rose only inthe vaccinated monkeys. A transient increase of alkaline phosphatase and erythrocyte sedimentation rate was noticed in half of them. We conclude that this type of malaria vaccine causes moderate adverse reactions in Aotus but they are transitory and seem not to lead to permanent damage.
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PMID:Plasmodium falciparum merozoite vaccination in Aotus monkeys recovered spontaneously from P. falciparum infection: a clinical study. 675 60

Serum cholinesterase activities were determined in 87 patients of both sexes with P. falciparum malaria in comparison to those of 80 blood donors. Patients with acute P. falciparum malaria had significantly lower serum cholinesterase activity than those of the control group. After treatment, their serum cholinesterase levels returned to the normal level. Serum albumin concentration also showed the same pattern and had a direct relationship to those of serum cholinesterase levels. These findings indicated that malarial parasites had some effect on the liver cells which resulted in impaired hepatic synthesis of serum cholinesterase and albumin concentrations. This result therefore add new information that there was a disturbance of enzyme cholinesterase among many liver enzymes that have been shown to be altered during an acute malarial attack.
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PMID:Serum cholinesterase activity in patients with malaria infection. 701 93

389 pregnant women admitted for full- term, uncomplicated delivery at the Regional Hospital on the island of Zanzibar (Tanzania) were recruited to study the effect of malarial infection on birth weight in an endemic area. 3.8% of all newborns weighed less than 2500 g (i.e., low birth weight [LBW]). 21.4% of all women had peripheral parasitemias but no active placental infection. 17.6% had active placental infection but no peripheral parasitemia. 47.9% had both active placental and peripheral infections. Logistic regression analysis revealed that active placental infection was associated with LBW (15.5% vs. 1.2%; relative risk [RR] = 10.1, population attributable proportion [PAP] = 61.4%; p = 0.003). Serum albumin level less than 2.5 mg/dl was also associated with LBW (11.8% vs. 1.2%; RR= 10.2, PAP = 61.%; p = 0.008). Overall malarial infection was associated with LBW (6.5% vs. 1.8%; RR = 3.5; PAP = 55.4%; p = 0.04). These findings suggest that placental malaria causes intrauterine growth retardation, leading to LBW newborns and that malarial preventive interventions in pregnant women are needed in Tanzania.
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PMID:Malarial infection and birthweight in urban Zanzibar, Tanzania. 876 2