Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0024530 (malaria)
 44,886 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We report specific dyslipidemia in Gabonese children aged 18 months to 4 years old treated with Halfan for malaria. This is observed in addition to the hypoglycemia typically associated with malaria. C-HDL (high density lipoprotein) fell on day 0 (D0), then increased during the treatment. Triglycerides (TG), total cholesterol (TC) and non-esterified fatty acids (NEFA) rose on D0. CT continued to rise evenly throughout the treatment, whereas TG declined. The differences with respect to normal values are significantly different as assessed by the Student test. We report metabolic variation and tolerance to Halfan.
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PMID:[Lipid profile during specific malaria therapy in Gabonese children]. 778 Jun 73

A 44-year-old male, who had been to Lagos, Nigeria, was admitted to our hospital because of a high grade fever on July 20, 1993. On admission, Plasmodium falciparum was detected in his blood smears and the antibody titers against P. falciparum and Plasmodium vivax antigens were 1:256 and < 1:4 respectively by the indirect fluorescent antibody test. Therefore, he was diagnosed as having P. falciparum malaria. He was treated with halofantrine (Halfan: Smith Kline Beecham Pharmaceuticals, England), two tablets at six-hourly intervals, a total of six tablets (1500 mg). Parasites were cleared rapidly and remission was achieved without any adverse reactions. Halofantrine can therefore be recommended for the treatment of imported P. falciparum malaria.
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PMID:[A case of Plasmodium falciparum malaria successfully treated with halofantrine]. 817 81

In 1992, some 90 countries or territories where 42% of the world's population resided were considered malarious and estimation of deaths from malaria worldwide per year were in the order of 1.4 of 2.8 million. The higher the number of Japanese who go abroad becomes (the total number in 1994 was 13,578,934: Records of Statistical Division of the Ministry of Justice), the greater is the risk of their contracting malaria. Indeed, the reported annual number of imported malaria cases increased to not less than 100. Now, malaria should first be presumed if a patient complains of a higher fever after a visit to a tropical country. And the importance of instituting prompt diagnosis and proper treatment should also be stressed. One of the antimalarials which has been highlighted for its effectiveness is halofantrine. This drug has been used for treatment of human malaria since 1984, and to date clinical trials have involved about 3.4 million patients in more than 30 countries (personal communication). Several patients successfully treated with halofantrine without any treatment failure have also been documented in Japan. However, in 1993, a clinical study involving 400 patients on the Thai-Burmese border revealed cardiac effects of antimalarial treatment with halofantrine, including one sudden death after the treatment. There have also been some spontaneous reports of serious ventricular dysrythmiasis with prolongation of the QT intervals, rarely associated with death. The pharmaceutical company producing Halfan has reported 8 cardiac arrests, leading to 6 deaths, when a higher dose than recommended was used, there was recent or concomitant treatment with mefloquine, there was pre-existing prolongation of the QT interval or the patient had a thiamine deficiency. Finally, the World Health Organization (WHO) announced a "drug alert" on halofantrine advising a change in recommendations for its use. In the present paper, we discuss the first Japanese vivax malaria patient whose QT interval was prolonged after treatment with halofantrine.
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PMID:Prolongation of the QT interval observed in a Japanese patient with vivax malaria following treatment with halofantrine. 858 95

Due to dramatic development of modern means of transport, exotic countries located on distant continents are today within a few-hour reach by a jet. Every year several million people travelled by air in business or as a tourists. This results in easy transmission of parasitic and infectious factors from continent to continent or from country to country. Plasmodium vivax infection: diagnosis concerned 6 men who had returned from Thailand, India, Senegal and Zaire. The parasitosis was detected as a result of thin smear of periferal blond tests - there were found P. vivax trophozoites an shizontes in erythrocytes. In the patients we found haematologic and termoregulation disturbances as well as hapepatosplenomegaly. Halfan was applied in therapy. Plasmodium falciparum infection: the infection was found in a man and a women after return from Kenya and Sudan. The parasitosis was detected as a result of thin smear of peripheral blond test - there found trophozoites of the parasite in erthorocytes. The course of malaria in the woman was very severe with cerebral malaria, DIC syndrome and blond circulation disturbances, hepatocellular and nephrocellular damage. Entamoeba histolytica, HAV and Candida albicans mixed infections: found in men who had returned from India. Severe E. histolytica infection: diagnosed in a women after return from Greece. There were found massive lesion of large intestine mucosa and high-degree disturbances. Leptospirosis icterohaemorrhagiae infection: found in a man after return from Belarus. Haematologic disturbance and hepatocellular and nephrocellular damage were observed.
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PMID:[Selected parasitic and infectious diseases in persons returning from the tropics]. 1688 51