Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0024530 (malaria)
 44,886 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The post-malaria neurological syndrome (PMNS) is an unusual and relatively underreported complication of malaria, which usually occurs after the resolution of acute febrile illness and the patient is free from parasitemia. The clinical spectrum of the PMNS varies from acute-onset cerebellar ataxia to significant encephalopathy with focal deficits resembling acute disseminated encephalomyelitis. Uncommon presentations of PMNS include Guillain-Barre syndrome, postural tremor, or even isolated neuropsychiatric features. Although in a significant proportion of PMNS cases clinical resolution occurs with conservative treatment only, corticosteroids have been used in an attempt to hasten recoveries. Here, we present a case of a 12-year-old girl with acute onset, isolated neuropsychiatric features, following Plasmodium falciparum malaria. Neuroimaging, clinical examination, and cerebrospinal fluid studies were within normal limits. The child recovered completely after treatment with methylprednisolone pulse therapy. This case report illustrates the need for creating awareness about this uncommon complication of malaria. In view of the uncommon complication, early diagnosis and prompt treatment might help in the early resolution of symptoms.
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PMID:Case Report: An Adolescent Girl with Isolated Neuropsychiatric Features and Apparent Post-Malaria Neurological Syndrome. 3206 32

The majority of malarial neurological manifestations are due to plasmodium falciparum and the most dreaded is cerebral malaria. Post-malarial neurological syndrome (PMNS) is rarely reported in adults (<3%) and children (>10%) and includes a wide variety of neuro-psychiatric manifestations including the rare delayed cerebellar ataxia. We report a case of 60-year-old woman who had a prior history of fever and presented with cerebellitis. The importance of highlighting this case is because in malaria endemic regions awareness of neurological manifestations of malaria must be included in the differential diagnosis of cerebellar ataxia.
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PMID:Delayed cerebellar ataxia as a rare late presenting feature of falciparum malaria - A Case report. 3316 1


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