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Query: UMLS:C0024530 (malaria)
 44,886 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Eosinophilia was a frequently detected incidental finding during a prospective study of malaria seroepidemiology in Thailand. Blood eosinophil counts were performed every 3 months for a year in 823 Thai soldiers on border guard duty in a malaria endemic area. Soldiers developing malaria were admitted to hospital and more frequent eosinophil counts were done. P. falciparum parasitemia suppressed preexisting eosinophilia but eosinophilia returned following treatment. P. vivax and mixed infections had a similar but less marked effect on the peripheral blood eosinophil count. Eosinophilia in persons from a malaria endemic area may represent a normal late response to malaria infection.
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PMID:Eosinophilic response to falciparum malaria infections. 129 92

A 45-year-old man was admitted to our hospital with chief complaint of fever. The chest X-ray examination showed 2-3 mm fine nodular shadows throughout the entire lung fields. Eosinophilia was present in the peripheral blood. Spike-like high fever (39 degrees C) appeared every 48 hours. All bacteriologic cultures from blood, bone marrow aspirate, sputum, gastric juice, and bronchoalveolar lavage fluid were negative. Furthermore, the antibody titer of malaria was negative. No antibiotics were effective in this case. Histological examination of the transbronchial lung biopsy showed non-specific inflammation, but the open lung biopsy specimen showed scattering of tiny granulomatous lesions. These granulomas were composed of histiocytes with indented nuclei, fibroblasts, varying amounts of collagen fibers, and eosinophils. The histiocytes were positive for S-100 protein staining and identified as Langerhans' cells. Therefore, this patient was diagnosed as having pulmonary eosinophilic granuloma. Two months later, the abnormal shadows on the chest X-ray and high fever spontaneously resolved without steroid therapy. This case was considered to be unique with respect to the peripheral blood eosinophilia, the three-day fever, and spontaneous improvement, compared with the former reported case.
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PMID:[A case of pulmonary eosinophilic granuloma with three-day fever]. 156 29

The effects of eosinophilia on the course of Plasmodium berghei infection in mice were studied. Eosinophilia was induced by intravenous injection of Ascaris suum body fluid into the mice. Results indicated that eosinophils may play a role in the suppression of murine malaria. A significant reduction in parasitemias and increased survival time in eosinophilic mice occurred compared to mice not treated with A. suum body fluid. Reduction of parasitemia was effectively achieved when the mice were challenged with P. berghei, only after the level of eosinophils reached at least 10% of total white cell counts in the circulation. These findings may offer an additional explanation for the suppression of malaria in individuals with severe ascariasis.
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PMID:Plasmodium berghei: eosinophilic depression of infection in mice. 636 16

The exotic diseases are still far from a daily preoccupation and sometimes face the physician with unusual problems. Two classical situations are reported: eosinophilia of parasitic origin, and three examples of asymptomatic parasitosis. Eosinophilia is a classical sign accompanying multicellular parasites (helminths). The rate depends on the duration of the disease, the type of parasite and the scale of the infestation. Pathological eosinophilia is usually present before diagnosis is possible; hence it is necessary to repeat laboratory examinations. Several parasitic diseases are asymptomatic and, after a long evolution, cause serious complications. Examples quoted are malaria, for which there is no absolute prophylaxis, amoebiasis, which is responsible for hepatic necrosis in patients who have never had dysentery, and schistosomiasis, which insidiously causes irreversible hepatic necrosis and ureteral stenosis. These conditions are becoming increasingly frequent in our countries and call for closer attention.
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PMID:[Eosinophilia and dormant parasitosis]. 647 28

Expatriates are at risk for a number of infectious diseases for which short-term travelers generally are not at risk. Returning expatriates should undergo a detailed physical examination and a basic set of laboratory tests; these tests should be tailored to their specific history and exposures. Febrile patients with an appropriate exposure history must be evaluated for malaria; other potential diagnoses may be determined by incubation period, geographic exposure, and associated symptoms. When evaluating an ill returned expatriate with fever, it is important to exclude malaria, typhoid, leishmaniasis, brucellosis, tuberculosis, HIV infection, and syphilis. Gastrointestinal irregularities in expatriates may be caused by a number of infectious and noninfectious causes, including intestinal helminthiasis, strongyloidiasis, schistosomiasis, liver flukes, and amebiasis. Eosinophilia in returned expatriates often is associated with an infectious process and should be evaluated. Many infections associated with long-term overseas deployment may include dermatologic manifestations, including filariasis and leishmaniasis.
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PMID:Medical problems in the returning expatriate. 1504 71

Every year, millions of children travel internationally with their families, many to developing countries. Although the vast majority experience uneventful travel and return home well, it is not uncommon for children to present as ill during or after travel. Although the majority of travel-associated illness is mild and self-limited, serious conditions regularly occur. Almost all life-threatening conditions after travel present with fever, and malaria is the most important of these to rapidly exclude. Gastrointestinal symptoms are common after travel in the developing world, and most diarrhea in child travelers has a bacterial source. Children who have a rash in association with fever or who appear ill should receive a priority work-up focused on ruling out serious conditions. Many children traveling internationally experience respiratory illness during or shortly after travel, mainly common upper respiratory infections, yet serious conditions, such as tuberculosis, may occur. Eosinophilia is common in the returned pediatric traveler, particularly those with prolonged stays in the tropics. Not all eosinophilia is caused by parasitic infection; drug reactions, asthma, and other allergic conditions are also common causes. With a focus first on ruling out life-threatening disease and subsequently on an informed and efficient path to diagnosis and treatment, clinicians may confidently provide care for this challenging group of patients.
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PMID:Evaluating a sick child after travel to developing countries. 2105 65