Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0024530 (malaria)
 44,886 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Neurological malaria, characterized by significant cerebral involvement, is the most worrisome aspect of Plasmodium falciparum malaria, with a mortality rate of 10-30%. Neurological malaria is generally limited to immunodepressed subjects. Children aged 4 months to 4 years and foreigners who have neglected their chemical prophylaxis are at risk. In weakly endemic areas, native adults who have not built up immunity may also be at risk. 1844 children hospitalized for malaria were studied in 1995 for clinical indicators of gravity. The risk of death was evaluated for each of 10 criteria suggested by the World Health Organization and 5 simple additional parameters. An initial coma, cardiovascular collapse, and repeated convulsions were major factors in mortality. Acute anemia, acidosis, and elevated parasite levels did not worsen the prognosis, but severe hypoglycemia, severe respiratory distress, and jaundice were associated with poor outcomes. The majority of children who died suffered respiratory distress on admission to the hospital, which often complicated the diagnosis of malaria. Nearly all died within 24 hours of admission. Knowledge of the factors associated with mortality should facilitate referral of patients who need higher levels of care.
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PMID:[Criteria of gravity of neurological malaria in children]. 1232 46