Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0024530 (malaria)
 44,886 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Serum vitamin B12 and vitamin B12 binding proteins (transcobalamins, TCS) were determined in patients with malaria, amoebic liver abscess, carcinoma of the liver, infectious hepatitis, cirrhosis and chronic myelocytic leukemia (CML) as well as in 60 blood donor subjects. Serum vitamin B12 in patients with infectious hepatitis, cirrhosis and CML were higher than that of the normal subjects. The values of unsaturated vitamin B12 binding capacity (UBBC) in patients with carcinoma of the liver, infectious hepatitis, cirrhosis were lower while that of patients with CML were higher than that of the normal subjects. A markedly increased TCI and decreased TCII was observed in patients with CML while these changes was much less in patients with other liver diseases. The difference was possibly due to a flooding of vitamin B12 from damaged liver cells into the circulation and the decreased synthesis of transcobalamins in patients with liver diseases while the increased granulocytes, the source of TCI, was much increased in patients with CML.
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PMID:Vitamin B12 and vitamin B12 binding proteins in liver diseases. 60 23

Febrile infections can be fatal in travelers to tropical countries unless the patient seeks medical care in a timely manner and the physician takes the time and has the skill to make a rapid diagnosis and prescribe appropriate therapy. In addition to the usual febrile illnesses present in temperate climates, the patient may have an "exotic" infection, e.g., malaria, infectious hepatitis, enteric fever, or dengue fever. The potential causes of fever in travelers are extensive. This article provides practical clues to assist the physician in making the correct diagnosis--by using exposure information, symptoms and signs, and concomitant symptom complexes.
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PMID:Fever in the returned traveler. 140 24

The case notes of all patients who died over the January 1980 to December 1985 period in Tikur Anbessa Teaching Hospital, Addis Ababa, Ethiopia, as a result of conditions associated with pregnancy, labor, and puerperium were reviewed in an effort to identify the most common causes of maternal death. Postpartum autopsy seldom was possible; consequently, the cause of death was based on clinical findings only. 216 deaths occurred over the 6-year period; there were 22,404 live births in the same period, giving a maternal mortality rate (MMR) of 9.6/1000. This rate included deaths from complications following abortions. 197 of the deaths occurred in women who were not booked into Tikur Anbessa Hospital. In terms of direct causes of death, abortion, puerperal sepsis, and ruptured uterus together accounted for 75.9% of deaths. Of indirect causes, infectious hepatitis, relapsing fever, and malaria accounted for 56.8% of deaths. Of deaths due to abortion, 21/48 occurred in nulliparas, and 25 were below age 19. Of the deaths caused by ruptured uterus, 20/29 occurred in multipara, and all of those women were from rural areas. The majority of deaths from hepatitis occurred in the 30-34 years age group. In Ethiopia, the maternal mortality rate is high because of both poor or inadequate antenatal and postnatal care as well as because of poor transportation and communication systems.
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PMID:A six-year review of maternal mortality in a teaching hospital in Addis Ababa. 341 42

A survey is given of the occurrence of communicable diseases in the Federal Republic of Germany including Berlin (West) in 1979. The epidemiological situation was dominated by salmonellosis, infectious hepatitis, scarlet fever, and meningitis. There was a striking increase in imported tropical diseases, such as malaria and leprosy. Poliomyelitis continued to decrease. There was an insignificant number of influenza cases in the winter 79/80. Due to the coming into force of the Amendment of the Federal Communicable Diseases Act on 1 January 1980 the obligation to notify communicable diseases has been changed in some respects. Moreover, the statistical data on communicable diseases have been collected and published only quarterly.
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PMID:[The epidemiologic situation of infectious disease in West Germany in 1979]. 721 10

The incidence of nine water-related diseases in the Brak oases of the Sahara desert, before and after the installation of water treatment plants, are reported. Immediately following installation of the plants there was a drop in the incidence of most of the water related diseases. There then followed a gradual deterioration in the treatment plants and within a year the incidence of four of the diseases was again rising. Furthermore neither malaria or giardiases showed any drop in incidence over the study period. Bacillary dysentary, infectious hepatitis and bilharzia did however drop significantly over the three years. A correlation between bacillary dysentary and the mean noon-time temperature for two of the three years was noted.
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PMID:The incidence of water-related diseases in the Brak area, Libya from 1977 to 1979, before and after the installation of water treatment plants. 732 13

Under analysis was the course of the postoperative period in 216 patients subjected to closed mitral commissurotomy. The risk of local infectious complications was found to be higher in patients with the IVth stage of mitral stenosis having lymphopenia, hypopotassemia, hyponatremia, hypochromic anemia, higher ESR in the postoperative period who had malaria and infectious hepatitis in the medical history.
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PMID:[Certain factors increasing the risk of local infectious complications following closed mitral commissurotomy]. 742 54

After her holiday in South Africa, a 50-year-old woman was admitted because of fever and pain in the upper abdomen. The laboratory tests showed moderately increased serum liver enzyme activities. The liver biopsy showed a granulomatous hepatitis. Further investigations revealed no evidence for sarcoidosis, tuberculosis or infectious hepatitis, nor for other granulomatous diseases or infectious diseases relevant to South Africa. Upon discontinuation of the malaria prophylaxis with Daraclor (pyrimethamine and chloroquine (sulphate)) the symptoms disappeared and the liver function tests returned to normal. It was concluded that Daraclor was the probable cause of granulomatous hepatitis in this patient. This adverse effect was not published before.
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PMID:[Granulomatous hepatitis attributed to the combination pyrimethamine-chloroquine]. 872 Jul 7

India is the second most populous country of the world and has changing socio-political-demographic and morbidity patterns that have been drawing global attention in recent years. Despite several growth-orientated policies adopted by the government, the widening economic, regional and gender disparities are posing challenges for the health sector. About 75% of health infrastructure, medical man power and other health resources are concentrated in urban areas where 27% of the population live. Contagious, infectious and waterborne diseases such as diarrhoea, amoebiasis, typhoid, infectious hepatitis, worm infestations, measles, malaria, tuberculosis, whooping cough, respiratory infections, pneumonia and reproductive tract infections dominate the morbidity pattern, especially in rural areas. However, non-communicable diseases such as cancer, blindness, mental illness, hypertension, diabetes, HIV/AIDS, accidents and injuries are also on the rise. The health status of Indians, is still a cause for grave concern, especially that of the rural population. This is reflected in the life expectancy (63 years), infant mortality rate (80/1000 live births), maternal mortality rate (438/100 000 live births); however, over a period of time some progress has been made. To improve the prevailing situation, the problem of rural health is to be addressed both at macro (national and state) and micro (district and regional) levels. This is to be done in an holistic way, with a genuine effort to bring the poorest of the population to the centre of the fiscal policies. A paradigm shift from the current 'biomedical model' to a 'sociocultural model', which should bridge the gaps and improve quality of rural life, is the current need. A revised National Health Policy addressing the prevailing inequalities, and working towards promoting a long-term perspective plan, mainly for rural health, is imperative.
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PMID:Current health scenario in rural India. 1204 9

Although dams have beneficial effects, they are also acknowledged as having serious environmental repercussions if they are not properly managed. The objective of this work was to examine the impact of the Barekese Dam in Ghana on the health status of three riparian communities downstream against a control. The environmental health status of the communities was analysed with reference to traditional endemic communicable water-related diseases in the catchment area, which were identified as malaria, urinary schistosomiasis, infectious hepatitis, diarrhoeal diseases and scabies. Case-control study was then conducted in the three phases of the dam (pre-construction, at the end of the construction and in the late operational phases) to analyse the health status of the communities as a function of the phases of the dam. The results showed that the control community consistently had a much better health status than two of the riparian communities, which were closer to the dam in all the three phases. However, it had a better health status than the third riparian community, which was farthest downstream, only in the first two phases. This community maintained a fairly constant health status retrospectively and did not appear to have been affected by the presence of the dam. On contrary, the health status of the two communities in close proximity to the dam deteriorated in the late operational phase. The study therefore showed that there was a strong association between the presence of the dam and poorer health status of the downstream communities in close proximity to it.
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PMID:An analysis of the environmental health impact of the Barekese Dam in Kumasi, Ghana. 1525 Dec 25

One of the great demands and challenges for vaccination is to successfully target the pathogens responsible for much of mankind's chronic disease burden including: AIDS, infectious hepatitis, tuberculosis and malaria. Another is realizing the potential of therapeutic immunization to cure diseases such as cancer, allergy and inflammatory autoimmunity. To achieve these objectives, the fundamental insights gained from immunology, genomics, molecular-cellular biology and vaccinology must be implemented in order to develop more effective, better defined and safer vaccines. As an illustrative example of this we examine the key features of viruses that are known to be responsible for eliciting superb host immune responses. These insights have formed a basis for understanding the effectiveness of existing vaccines and provide a framework for designing and developing new vaccines better able to meet pressing unmet medical needs. The key immunogenic properties of viruses that are understood to date and are currently being applied include: their particulate nature, their highly repetitive and ordered structures, their ability to induce innate immunity with consequent conditioning of adaptive responses and the kinetics and distribution of viral antigens during infection. Vaccines and vaccine-formulations recently registered for use in humans already incorporate some of these elements. Of great anticipation is the progress of the next-generation vaccines now advancing through the various stages of research and development. Vaccines which, by way of rational design, incorporate viral properties to induce tailored responses and thus have the potential to provide safer and more effective prophylaxis and therapies.
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PMID:Designing recombinant vaccines with viral properties: a rational approach to more effective vaccines. 1734 67


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