Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0024530 (malaria)
 44,886 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Malaria causes an estimated 300-500 million clinical cases in sub-Saharan Africa and Indochina. The most severe form of malaria is caused by Plasmodium falciparum, a parasite responsible for the death of 2 million children annually. Understanding the molecular basis of the parasite's invasion process is important for the development of new drugs and vaccines. Invasion of erythrocytes by the malaria parasite is a multistep process involving several specific interactions between the parasite's ligands and receptors on red blood cells. It was shown that glycophorins A, B, and C, sialoglycoproteins of human erythrocytes, act as receptors for Plasmodium falciparum ligands of the DBL family: EBA-175 and EBA-140 antigens. The binding specificity of EBA-175 is determined by the presence of sialic acid residues of the O-linked oligosaccharide chain clusters of glycphorin A and the amino-acid sequence, which contribute to their proper conformation. Glycophorin B, the next in terms of amount, can take on the role of glycophorin A as the receptor, but the glycophorin B- and sialic acid-dependent invasion of erythrocytes by Plasmodium falciparum involves a different parasite ligand. The third, and minor, glycophorin C appears to be the receptor for the antigen BAEBL, a paralogue of EBA-175. The binding of BAEBL to glycophorin C is dependent on the sialic acid residues of the O- and N-linked oligosaccharide chains and a peptide as well. It seems that the correct receptor site on glycophorin C needs to be elucidated in detail.
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PMID:[Glycophorins of human erythrocytes as receptors for the malaria parasite Plasmodium falciparum]. 1806 20

African populations are characterized by high degree of genetic diversity. This high genetic diversity could result from the natural selection pressure. Several studies have described an association between some genetic diversities and difference of susceptibility to infectious diseases like malaria. It seems therefore important to consider genetic diversity impact when interpreting results of clinical trials in malaria endemic areas. This study aimed to determine the genetic polymorphism with erythrocyte traits in different populations of malaria endemic area in Mali. The cross-sectional surveys were carried out in different ethnic groups living in malaria endemic areas in Mali. Six milliliters of whole blood were collected in EDTA vials from each participant after informed consent has been obtained. The ABO, RH, Kell, MNSs, Kidd and Duffy systems phenotypes were assessed by the technique of gel filtration. A total of 231 subjects were included from six villages. The blood groups phenotypes O (40.7%) and A (31.2%) were more frequent with respective allele frequencies of 0.65 and 0.21. In the RH system the haplotypes R0 (0.55), r (0.20) and R1 (0.13) were the most frequent. Seven percent (7%) of Duffy positive and 4% of Glycophorin B deficiency (S-s-) were observed among participants. All participants were Kell negative. ABO and RH systems were polymorphic in these ethnic groups in Mali. Their implication in susceptibility to malaria should be taken into account in clinical trials interpretation, and for prevention of blood transfusion risks during anemia frequently caused by malaria in children.
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PMID:Genetic polymorphisms with erythrocyte traits in malaria endemic areas of Mali. 3060 64