Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0024530 (malaria)
 44,886 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Eighty cases of fever of undetermined origin seen at Dallas VAMC from 1979 to 1985 were analyzed. Infectious etiology was the cause in one half, with equal numbers of localized infections or systemic infections. In contrast to older series, viral infections were frequently seen, but tuberculosis and malaria were less commonly noted. Solid tumors were the most frequently diagnosed non-infectious cause of fever. Fevers secondary to malignancy commonly responded to non-steroidal anti-inflammatory agents. Patterns of illness were helpful in defining certain diseases such as adult Still's disease and polymyalgia rheumatica. Diagnostic tests of value are discussed.
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PMID:Fever of undetermined origin: not what it used to be. 371 5

Brucellosis is a systemic infectious disease caused by Gram-negative bacilli, the genus Brucella, and clinical features are diverse. Therefore, several infectious and non-infectious diseases are considered in its differential diagnosis. In this study, we aimed to determine the positivity rate of Brucella agglutination tests in the culture-positive brucellosis and in diseases mimicking brucellosis clinically.Thirty patients with culture-positive brucellosis, and 280 patients with the diseases mimicking brucellosis clinically (20 with miliary tuberculosis, 33 with malaria, 20 with typhoid fever, 20 with adult-onset Still's disease, 47 with systemic lupus erythematosus, 50 with rheumatoid arthritis, 27 with sarcoidosis, and 63 with active lymphoma) were included in the study. Brucella agglutination tests (Rose-Bengal and Wright) were studied in serum samples of these 310 patients. Both Rose-Bengal and Wright tests (the latter in a titer of 1/160 or higher) were positive in all patients with brucellosis. For the other diseases, the test was slightly positive (1/40) in one patient with malaria and another with non-Hodgkin's lymphoma, and weakly positive (1/20) in a patient with typhoid fever. It remained negative in the remaining. In conclusion, agglutination tests currently used in the diagnosis of brucellosis are very sensitive and specific. Brucellosis can be effectively excluded from the diseases having similar clinical features by the use of agglutination tests.
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PMID:The sensitivity and specificity of Brucella agglutination tests. 1294 13