Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0024530 (malaria)
 44,886 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Prompt malaria diagnosis is crucial so antimalarial drugs and supportive care can then be rapidly initiated. A 15-year-old boy who had traveled to Africa (South Africa, Kenya, and Nigeria between January 3 and 25, 2011) presented with fever persisting over 5 days, headache, diarrhea, and dysuria, approximately 17 days after his return from the journey. Urinalysis showed pyuria and hematuria. Blood examination showed hemolytic anemia, thrombocytopenia, disseminated intravascular coagulation, and hyperbilirubinemia. Plasmapheresis and hemodialysis were performed for 19 hospital days. Falciparum malaria was then confirmed by peripheral blood smear, and antimalarial medications were initiated. The patient's condition and laboratory results were quickly normalized. We report a case of severe acute renal failure associated with delayed diagnosis of falciparum malaria, and primary use of supportive treatment rather than antimalarial medicine. The present case suggests that early diagnosis and treatment is important because untreated tropical malaria can be associated with severe acute renal failure and fatality. Physicians must be alert for correct diagnosis and proper management of imported tropical malaria when patients have travel history of endemic areas.
...
PMID:Delayed Diagnosis of Falciparum Malaria with Acute Kidney Injury. 2751 Mar 97

Three hundred and two cases of falciparum malaria including 30 cases of severe falciparum malaria admitted between Jan 93 - Dec 93 were studied for their clinical features and response to treatment. Intermittent or remittent fever with chills and headache were the commonest presentation noted (99.3%). Cough (46.4%), hyperbilirubinemia (31.8%), and pyuria (52.9%) were the other notable features. Anaemia was uncommon (16.6%). Hypoglycacmia was detected in none of the cases. Quinine for 3 days along with tetracycline and sulfadoxine - pyrimethamine achieved a 100 per cent cure rate in uncomplicated chloroquine resistant falciparum malaria. Amodiaquine along with tetracycline and sulfadoxine - pyrimethamine was effective in 76.2 per cent of uncomplicated cases.
 ...
PMID:A CLINICAL STUDY OF FALCIPARUM MALARIA - 302 CASES. 2877 1