Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0024530 (malaria)
 44,886 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The early 20th century Southerner lived in a disease environment created by a confluence of poverty, climate and the legacy of slavery. A deadly trio of pellagra, hookworm and malaria enervated the poor Southerner--man, woman and child--creating a dull, weakened people ill equipped to prosper in the modem world. The Northern perceptions of the South as a backward and sickly region were only compounded by the realization that her population was malnourished, infected by worms, and continually plagued by agues and fevers. As historian John Duffy concluded, "As a chronically debilitating disease, it [malaria] shared with the other two the responsibility for the term 'lazy Southerner".
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PMID:Social consequence of disease in the American South, 1900-World War II. 1692 81

Pellagra is a curable dietary illness that unchecked leads to dementia, diarrhoea, dermatitis and death due to lack of the precursors for NAD(H). In addition it caused a wide range of monosyndromic degenerative and functional neurological disorders as well as profound developmental, premature aging and metabolic syndromes. Pellagrins harbour many chronic infections including tuberculosis, yeasts and malaria, that may be symbionts supplying nicotinamide adenine dinucleotide {NAD(H)} when the diet is poor. Many common diseases and aging may be caused by electrogenic energy mismatches from lack of a timely supply of NAD(H) creating disturbed metabolic fields and "protonopathies". Initially these may present in compartments fronted by homeostatic corrections from chronic symbiotic infections to inflammatory disease, cancer and degenerative/autophagic diseases that can all release NAD(H).
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PMID:Pellagra: A clue as to why energy failure causes diseases? 1734 50

Four major diseases stigmatized the American South in the nineteenth and twentieth centuries: yellow fever, malaria, hookworm, and pellagra. Each disease contributed to the inhibition of economic growth in the South, and the latter three severely affected children's development and adult workers' productivity. However, all four had largely disappeared from the region by 1950. This paper analyzes the reasons for this disappearance. It describes the direct effects of public health interventions and the indirect effects of prosperity and other facets of economic development. It also offers insights into the invaluable benefits that could be gained if today's neglected diseases were also eliminated.
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PMID:How four once common diseases were eliminated from the American South. 1988 14

The creation of the Italian Kingdom was characterized by the mass emigration of Italian people, mainly peasants towards European and American destinations. Poverty, unemployment, diseases, like pellagra, malaria and tubercolosis forced millions of Italians to leave the Country. The phenomenon of emigration is usually divided in three periods: the mass emigration from 1976 to 1914, the second one between the two world wars, the third one from 1946 to 1976. In the last quarter of the 20th century the number of repatriations overcome expatriations and the number of immigrants from Albania, Romania, Senegal, Tunisia, China, Philippines grew up becoming more and more important. Italy was a country of emigrants, now is a country of immigrants. It is difficult to compare the work conditions of the Italian emigrants with the new immigrants. At the end of the 19th Century or in the first decades of the 20th Century there were no consideration for human rights, no legislations to protect workers. Immigration from North Africa and from all the low and middle income countries should be studied in all its aspects because it will characterize our future. In the new era of economical globalization, Universities should prepare the new medical doctors to extend their professional culture to a international dimension to be able to cope with the new challenges of our time.
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PMID:[Emigration and immigration in Italy. (1861-2011)]. 2207 90

This paper presents the life and works of the famous doctor, hygienist, folklore researcher and sanitary mentor, Charles Laugier, whose contribution to the development of the medical system of Oltenia marked the beginning of the 20th century. He is noted for his research in hygiene, in the treatment of some diseases like: tuberculosis, malaria, pellagra, and also as the founder of numerous societies which contributed to the cultural and scientific development of the region of Oltenia and even of its small localities.
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PMID:The Biography of Doctor Charles Laugier (1875-1830). 2652 39