Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0024530 (malaria)
 44,886 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Owing to a misunderstanding a 26-year-old man took for malaria prevention 2 tablets (1.0 g) chloroquine daily instead of the recommended dose of two tablets weekly. After 2 weeks he developed vertigo, generalized weakness and, after sun-bathing, severe bullous light reaction. After 4 weeks generalized hair depigmentation occurred. Two weeks later abnormal accommodation and double vision set in so that he lost distant and near vision. All these signs disappeared after the drug was discontinued (vertigo, weakness and abnormal accommodation within 2 weeks; hair regrew in normal colour after 8 weeks). This case shows the whole spectrum of subacute chloroquine overdosage.
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PMID:[Subacute chloroquine overdosage]. 191 22

The success of Fred Soper and the Rockefeller Foundation's International Health Division in eradicating the Anopheles gambiae mosquito from Northeast Brazil was a significant watershed in the history of malaria control. It revived faith in vector control strategies and paved the way for the application of eradication methods in the fight against malaria following World War II. Yet Soper's achievement needs to be re-examined from a wider analytical perspective that takes account of the longer epidemiological history of malaria in Northeast Brazil and the wider social and economic context within which malaria occurred. The wider perspective suggests that the origins of the 1938/39 malaria epidemic were much more complex than Soper acknowledged. By focusing narrowly on the Anopheles gambiae mosquito and its eradication, Soper failed to understand this broader context. This myopia, in turn, permitted Soper to make claims for both the scale of his achievement and its importance for the future of malaria control which were unjustified.
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PMID:A land filled with mosquitoes: Fred L. Soper, the Rockefeller Foundation, and the Anopheles gambiae invasion of Brazil. 789 56

The success of Fred Soper and the Rockefeller Foundation's International Health Division in eradicating the anopheles gambiae mosquito from Northeast Brazil was a significant watershed in the history of malaria control. It revived faith in vector control strategies and paved the way for the application of eradication methods in the fight against malaria following World War II. Yet Soper's achievement needs to be re-examined from a wider analytical perspective that takes account of the longer epidemiological history of malaria in northeast Brazil and the wider social and economic context within which malaria occurred. This wider perspective suggests that the origins of the 1938/39 malaria epidemic were much more complex than Soper acknowledged. By focusing narrowly on the anopheles gambiae mosquito and its eradication. Soper failed to understand this broader context. This myopia, in turn, permitted Soper to make claims for both the scale of his achievement and its importance for the future of malaria control which were unjustified.
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PMID:A land filled with mosquitoes: Fred L. Soper, the Rockefeller Foundation, and the anopheles gambiae invasion of Brazil. 931 Dec 24