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Query: UMLS:C0024530 (malaria)
 44,886 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A non-immune, 31-year-old woman developed an acute infection with Plasmodium falciparum after travelling to Kenia. The parasites proved resistant to chloroquine and sulfadoxine/pyrimethamine. The course of the disease was complicated by acute renal failure, hepatocellular damage, disorders of blood coagulation, thrombocytopenia, hemolysis and cerebral involvement. Despite a very high level of parasitemia (50% parasitized erythrocytes) a rapid clinical improvement was achieved by plasmapheresis and hemodialysis. Our experience shows that plasmapheresis and hemodialysis are excellent additive methods which rapidly improve clinical symptoms and may reduce morbidity and mortality in severe malaria tropica.
Infection 1988
PMID:Successful treatment of malaria tropica with acute renal failure and cerebral involvement by plasmapheresis and hemodialysis. 322 May 82

The incidence of malarial infection in pregnant women at delivery, their corresponding infants and umbilical cords and a control group of non-pregnant women were investigated in the Madang region of Papua New Guinea. Anti-malarial antibody titres were measured in maternal and paired cord sera. Parasitaemia occurred in 18/73 (24.7%) of non-pregnant females compared with 15/51 (29.4%) of pregnant females. Malarial parasites were found in 7/48 (14.6%) cord blood samples and in 4/52 (7.7%) samples of the infant's peripheral blood, indicating transplacental transmission. Infection with Plasmodium falciparum was commoner in pregnant than non-pregnant females, and accounted for all the cord and infant infections. A significant correlation was found between anti-malarial IgG antibodies in paired maternal and cord bloods. There was an association between umbilical cord infection and low levels of cord antibody. Clinical malaria developed in at least one out of the 7 cases in which placental transfer of parasites was known to have occurred. This study suggests that transfer of parasites across the placenta is a common event in Papua New Guinea. Further consideration should be given to treatment with anti-malarial drugs of infants with cord or peripheral blood parasitaemia or, indeed, of all infants of mothers with parasitaemia.
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PMID:Congenital malaria in Papua New Guinea. 209 31

Infections caused by parasites are common and not limited to the developing world. The spectrum of interactions between pregnancy and parasite infection ranges from minor discomfort to fetal death and are well illustrated by the problems of toxoplasmosis and malaria.
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PMID:Parasites and pregnancy: the problems of malaria and toxoplasmosis. 328 27

Swiss mice with chronic Trypanosoma brucei infections become refractory to subsequent infection with Babesia microti and B. rodhaini. Infection with B. microti 7 days after T. brucei resulted in an obvious inhibition of the babesia parasitaemias and this inhibition became more profound as the time interval between the infections increased, until at 17-20 days the parasitaemias were totally abolished. Even after intravenous injection of large numbers of parasites parasitaemias were inhibited. Similar inhibition was obtained in BALB/c mice but not in C57BL/6 mice. Mice with established T. brucei infections also showed reduced susceptibility to B. rodhaini. In mice similarly infected with T. brucei and the malaria parasites Plasmodium chabaudi chabaudi and P. c. adami the pre-patent periods were noticeably prolonged but the subsequent parasitaemias were unaffected. Infections with P. yoelii were unaffected. Trypanosoma brucei infections were not affected by the intracellular parasites. Among the mechanisms investigated to explain these findings were changes in red blood cell populations, cross-reacting antigens, the release of toxic factors and the generation of activated oxygen species. None of these could account for the inhibition observed.
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PMID:Interactions between Trypanosoma brucei and Babesia spp. and Plasmodium spp. in mice. 400 Jul 2

A prospective longitudinal study of malaria incidence was carried out in randomly selected samples of the population in the villages of Bu Phram and Tablan, north-east Thailand. During the 10-month study period 46% of the 252 persons followed up experienced a falciparum parasitaemia, and 23% a vivax parasitaemia. The peak of the cases occurred during a 10-week period from late May to the end of July, with transmission apparently continuing, at lower levels, throughout the remainder of the study period. Falciparum infection rates were higher for residents of Bu Pham; vivax infection rates were the same in both villages. Certain indices declined with age in Bu Phram but not in Tablan residents. Parasite rates were higher for males than for females. Age-specific rates did not vary predictably. Infection of children aged less than one year was rare.
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PMID:Longitudinal malaria studies in rural north-east Thailand: demographic and temporal variables of infection. 461 38

Malaria is a treatable, potentially fatal disease. A detailed travel history and personal attention to laboratory diagnosis are essential. Infection related to current military ventures plus continued ever increasing civilian travel make it a disease to be borne in mind by medical practitioners.
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PMID:Malaria: an "imported" disease to be reckoned with in the U.S. 556 14

The malaria infection rates in non-immune residents of Dar es Salaam on various chemoprophylactic regimens were compared with that (37.1%) in those not taking prophylactic antimalarials. Among 647 people resident in Dar es Salaam for 1-6 years the two groups with the lowest infection rates by person-episodes (2.0% and 1.5%) were those taking proguanil 200 mg daily alone or with chloroquine base 300 mg weekly. Infection rates (16.9% and 14.0%) were also significantly lower than in the no-prophylaxis group in those taking chloroquine base 300 mg weekly combined with 'Fansidar', 'Maloprim' (each one tablet weekly), or proguanil 100 mg daily. No significant reduction in the malaria attack rate was found in those taking chloroquine base 300 mg or 600 mg weekly (31.2%), pyrimethamine 25 mg weekly (27.3%), proguanil 100 mg daily (46.4%), maloprim one tablet weekly (40.4%), or a combination of chloroquine base 300 mg weekly and pyrimethamine 25 mg weekly (27.1%). Similar results were obtained when the infection rates per year of exposure were compared. Proguanil was associated with fewest user complaints and fansidar with most.
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PMID:Chemoprophylaxis of malaria in non-immune residents in Dar es Salaam, Tanzania. 614 92

Infections of mammalian malaria parasites start when sporozoites from an infected anopheline mosquito are injected into the bloodstream of the host. The sporozoites enter the hepatocytes and become transformed into exoerythrocytic schizonts. Since the discovery of the primate parasite Plasmodium cynomolgi in monkey hepatocytes and the rodent parasite Plasmodium berghei in hamster hepatocytes, the ultrastructure of these stages has been extensively studied both in primate and rodent plasmodia. These observations relate only to the development of the exoerythrocytic schizont 25 h after sporozoite injection until the final maturation (of P. berghei) 50 h post-inoculation. Recently, we have studied the route of entry of sporozoites across the cellular lining of liver sinusoids and invasion of the liver parenchymal cells by using transmission electron microscopy. The results of these studies in combination with other physiological experiments strongly suggested that the sporozoite was initially harboured by the Kupffer cell, from which the parasite escaped into the neighbouring hepatocyte. The migration of sporozoites from liver sinusoids to hepatocytes can be achieved within a few minutes. We present here the first ultrastructural observations on the natural transformation of intrahepatocytic sporozoites into exoerythrocytic forms in vivo, using the rodent malaria parasite P. berghei in a laboratory host, the Brown Norway rat. These observations complete the search for the final link in the life cycle of malaria parasites.
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PMID:Malaria parasites--discovery of the early liver form. 633 45

The relationship between exposure to Plasmodium vivax infection and the onset of fever in travellers returning to Glasgow from the Indian subcontinent is presented. Infection appears more likely in those who travel during the second half of the year and following the monsoon. Most attacks of malaria begin during the summer months in Scotland irrespective of the dates of travel.
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PMID:The seasonal pattern of Plasmodium vivax malaria in Glasgow. 636 64

Infection with Plasmodium berghei malaria is severely inhibited in rats fed on a low protein diet. A range of amino acid supplements was added to a 4.2% casein diet to determine whether the relationship between level of infection and protein content could be attributed to the dietary amounts of the essential amino acids. Significant increases in levels of infection were achieved by supplementation with specific combinations of amino acids. Threonine was most effective in increasing the degree of parasitaemia but its effect was further enhanced when it was combined with dietary excess of certain other amino acids, notably valine, isoleucine and methionine.
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PMID:Increased severity of malaria infection in rats fed supplementary amino acids. 639 37


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