Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0024530 (malaria)
 44,886 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

According to the World Health Organization, 585,000 women die each year from a pregnancy-related cause, 99% of whom are from developing countries. The first International Conference on Safe Motherhood in 1987 sensitized the world community to this drama. Ever since, maternal mortality and its medical causes are better known. The maternal mortality ratio is highest in West Africa (1,020 maternal deaths per 100,000 live borns) when it is 27/100,000 in industrialized countries. Direct obstetric causes account for 80% of the deaths: hemorrhage, infection, dystocia, hypertension and abortion. Indirect causes are essentially anemia, malaria, hepatitis C and AIDS. Severe maternal morbidity is 6 to 10 times more frequent than maternal mortality but it also leads to handicaps which end up often in women's social rejection. However, WHO estimates that 95% of these deaths and handicaps are avoidable, and at a low cost.
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PMID:[Pregnancy and delivery in western Africa. High risk motherhood]. 1050 33

In tropical areas, parasitic diseases are very frequent during pregnancy. Malaria is the most frequent, with different complications in pregnant women (anaemia, cerebral malaria, abortion) and in the fetus (low birthweight, congenital malaria), mostly after first pregnancies. Diagnosis must be confirmed rapidly and the treatment is effective with most of antimalarial drugs. Prophylaxis is possible by intermittent sulfadoxine-pyrimethamine treatment. Hookworms infestation increases the anemia. Schistosomiasis can be liable to sterility or dystocia. Congenital transmission of visceral leishmaniasis is exceptional. Digestive parasitosis give few repercussion on pregnancy and their treatment is useful only if clinical troubles are important.
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PMID:[Parasitic diseases and pregnancy]. 1743 18

Saimiri (squirrel monkey) is a neotropical primate of the Simian genus that has been bred in captivity for the development of research into human and animal health. They have been widely used in studies in ophthalmology, toxicology, pharmacology, psychiatry, neuroscience, vaccines and drug tests (such as malaria and measles agents), as well as effects on interactive behavior and cognition of Creutzfeldt-Jakob disease in man. The main concern of non-human primate (NHP) research centers is focused on the establishment of self-sustaining breeding colonies providing good quality research animals. Maternal rejection, dystocia and pneumonia are the main causes of newborn deaths in these species. Therefore, in order to ensure the survival of these valuable animals, the Laboratory Animals Breeding Center of the Oswaldo Cruz Foundation (CECAL)/Fiocruz, Rio de Janeiro, Brazil, has developed a protocol for the nursery rearing of these infants.
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PMID:Neotropical primate nursery in a squirrel monkey breeding unit in Brazil. 2565 70