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Query: UMLS:C0024530 (malaria)
 44,886 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The authors make a study of malaria morbidity in Dakar during October and November 1988 in Dakar where malaria is endemic but with a pick in pathophoresis during the rainy season. Out of 353 surveyed cases of malaria, 110 were carriers of Plasmodium falciparum, i.e., 31%. Mean parasitic density was 7462 red cells/mm3 and more than an half of patients got an higher density. Parasitic density was higher in children (0-14 years old) than in adults, but with no significant indication. Malaria fever represents 20.4% of all types of fever observed and was the first cause to consult during the rainy season. Whatever threshold of parasitic density selected parasitologic criterion may be in order to identify a malaria fever, percentage of diagnosis misinterpretation linked up to clinical examination was always higher than 30%.
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PMID:[Malaria morbidity in the urban environment. Study of 353 fever attacks]. 269 36

The practices of health care workers and the population with regard to diagnosis of malaria and use of antimalarial drugs were studied in the city of Dakar from September 1991 to March 1992. Study included 847 heads of family, 191 treatment prescribers including 77 physicians, 53 nurses and 61 midwives, and 60 pharmacists. Three separate questionnaires were used: one for the population, one for physicians and paramedical staff, and one for pharmacists. The data collected showed that the 4 main symptoms used by both health care workers and the general population for diagnosis of malaria were fever, chills, vomiting, and headache. Treatment was administered upon suspicion of infection by 72% of treatment prescribers. Chloroquine was the drug most widely used by prescribers and for self-treatment of malaria. Prophylactic drug treatment was practised by all groups studied except treatment prescribers but was unappropriate for the target groups. Chloroquine is the drug most widely used to protect against the disease. Pharmacists have adequate supplies but distribution is poor. Despite promising results in the fight against malaria, further effort is needed to train health care workers and provide information to the population.
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PMID:[Health personnel and population practices in the diagnosis of malaria and use of antimalarial drugs in Dakar]. 763 9

A questionnaire survey was conducted in the Dakar region (Senegal) between August and October 1992 to investigate diagnosis and treatment practices for uncomplicated malaria attacks in the health care facilities. The sample consisted of 208 prescribers in the operational sense i.e. 20% of the following professional categories: medical doctors, health care technicians, birth attendants, qualified nurses, and auxiliary nurses. A thick smear was mentioned as a diagnostic element by 23% of the practitioners; chloroquine remained the first choice drug for 80% of the personnel but 13% declared prescribing parenteral quinine for uncomplicated malaria in patients without vomiting; halofantrine and the association sulfadoxine-pyrimethamine-mefloquine are prescribed by respectively 7 and 1% of the personnel, also in the public sector; chloroquine is prescribed in an effective dose (25-40 mg/kg) by 74% of the personnel for adults and by 43% for children; quinine base in a dose below 25 mg/kg by 100% of personnel for adults and by 99% for children; nearly half of the prescribers do not take into account the children's weight; 13% of the practitioners prescribe useless expensive symptomatic treatments and 45 to 73% ignore the price of the common antimalarials, allowing for a 10% error; health care workers have a bad knowledge of the results of chemosensitivity surveys. The development of a national malaria control programme that emphasises permanent training of the health care workers and control of therapeutic information seems mandatory.
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PMID:[Diagnostic and therapeutic management of uncomplicated malaria attacks in the Dakar region, Senegal]. 772 63

In the aim to determine the possible role of HLA-antigens in malaria infection, sera from 50 HLA-typed donors from Dielmo (Senegal) were tested in immunoblotting (using crude merozoites as antigen) and immunoprecipitation (using detergent-extracts from surface-iodinated merozoite as antigen). The donors were previously tested on lymphocyte proliferation in vitro and gamma-interferon production and grouped into two classes: high responders and low responders. In immunoblotting and immunoprecipitation experiments, no specific differences were found in the antibody reactivity with native merozoite antigen in individuals with high (HR) or low (LR) in vitro proliferative T cell responses. In other words, both groups of responders, high and low, showed antibodies in their sera against a wide range of different parasite antigens; although between individual donors striking differences were found. Individual donors had developed different levels of antibodies, or no antibodies at all, against individual natural antigens. These differences, however, could not be correlated with HR or LR. The band patterns obtained were compared with HLA-antigens of donors phenotypes. Results showed that there was no correlation found between the different merozoite antigens recognized by sera of the different donors or groups of donors (HR and LR) and the donors' HLA-phenotypes. The fact that donors with HLA-B51 all recognized (MSP1(42) and donors with DR1 recognized MSP1(19), was not a convincing correlation.
Dakar Med 1993
PMID:[Analysis of the antibody response to merozoite antigens in a malaria holoendemic area]. 775 76

Inside of 95 patients presented in Hospital with presumed hepatitis: 77 were recruted with liver cytolysis (Amino-Transferases AT > 80 UI/ml) and included in this study. Study of serologic viral markers (A, B, C, D and E type) permited to prove viral acute hepatitis infection and 49 patients were recruted inside the 77 cytolytic cases. Inside these 49 cases: 44% presented enteritic contamination with HAV/HEV markers, 36% with HBV markers: HBs/HBc, 6% with HBs/HBe markers, 10% with HDV marker, 4% with HCV marker. 28 patients presented any viral acute hepatitis marker and in this case can be evocated other hepatitis origin: viral hepatitis type (EBV), CMV, chronic hepatitis evolution, malaria hepatitis or toxic hepatitis.
Dakar Med 1993
PMID:[Viral markers of acute hepatitis: A, B, C, D, and E in Dakar. October 92 - October 93]. 775 79

During November and December 1992, the authors surveyed the malaria morbidity and the drugs efficiency in an urban area of Dakar region. Malaria represented 13.68% of the fevers in Dakar district and 12.4% in Pikine. The mean parasitic density was evaluated at 5000/mm3. Good efficiency of antimalarial drugs were noted but chloroquine-resistance is present with 24% of prevalence.
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PMID:[Malaria morbidity and therapeutic efficacy of antimalarials. Study conducted in the Dakar region]. 813 36

To measure morbidity due to malaria and to study its relationship with transmission and parasitemia in children living in an area of low malaria endemicity, a cohort study of 343 schoolchildren was undertaken during a one-year period in Dakar, Senegal. From parallel investigations on transmission and the frequency of malaria as a cause for outpatient visits, three different seasons were chosen for close monitoring of different clinical parasitologic, and sero-immunologic parameters. The daily incidence rates of malaria parasitemia and primary attacks were at a maximum level during the high transmission season (0.00198 and 0.00185 new cases/person/day, respectively) and decreased considerably during the season of low transmission. For each given period, the values of these two rates were close to each other, suggesting that each new infection was followed by a clinical attack. During the period of maximum transmission, clinical malaria prevalence was 1.36% and malaria was responsible for 36% of school absences due to medical reasons. At the end of the period of minimum transmission, clinical malaria prevalence was 0.15% and malaria was responsible for 3% of school absences due to medical reasons. In contrast, parasite prevalence hardly varied with the season (minimum 3.6%, maximum 7.5%). In a one-year period, the total number of new malarial infections was estimated between 173 and 230. Because of the existence of a vector density gradient in the area concerned, the annual malaria incidence varied considerably according to the children's place of residence.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Malaria morbidity among children exposed to low seasonal transmission in Dakar, Senegal and its implications for malaria control in tropical Africa. 833 68

In this paper, we will summarize the progress obtained in the malaria vaccine project developed by the Institut Pasteur groups interacting through the International Network of Pasteur Institutes over the last fifteen years. While trying to follow the progress in scientific and technological concepts and methodologies, the basic approach was still essentially the same as that followed by Pasteur and his acolytes to try to artificially reproduce the natural processes that lead to the development of immunity to infection and disease. A longitudinal study of two villages from the Sine Saloum area of Senegal, Dielmo and N'Diop, conducted in recent years by teams of the Institut Pasteur of Dakar, Senegal, in collaboration with the local ORSTOM malaria unit has led to the detailed analysis of the natural acquisition of premunition against Plasmodium falciparum malaria in endemic areas. The Saimiri model developed at the Pasteur Institute in Cayenne, was an important step forward in terms of studies on the mechanisms of action of protective antibodies and on vaccinations assays. If we accept the conclusions of the Pasteur groups' research on the experimental primate model and on the development of natural immunity (premunition) in highly endemic areas, the main inhibitor of progress in vaccine development is our poor understanding of the regulation of the immune response. Therefore, the general approaches that were followed for vaccine development must now be further explored using the continually developing tools of immunology and molecular biology, to elucidate regulations of the immune responses to the parasite, and identify the molecular mechanisms used by the parasite to generate and change antigen specificities.
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PMID:Towards a vaccine against asexual blood stage infection by Plasmodium falciparum. 857 88

The Niayes is geographically characterized by an alternating succession of sand dunes and wet depressions, 20 km wide, which are behind the offshore bars from Saint-Louis to Dakar. Since 1970, the area has been affected by drought. The rainfall which was around 700 mm per year before 1960 has fallen below 500 mm during the last 30 years. In 1991 it was only 350 mm and in 1992, 260 mm. The vegetation has become impoverished in the depressions which are now more and more cultivated for vegetables. Entomological, parasitological and clinical studies on malaria were carried out in 1991 and 1992 in three villages and the results were compared with data gathered from 1967 to 1968 with comparable methods. The main points concerning the evolution of malaria are listed as follows. An. funestus, which was previously the predominant malaria vector, has almost disappeared. An. gambiae has regressed ahead of its sibling species An. arabiensis, a less competent vector. These changes in vector populations have led to lower malaria transmission and consequently a decrease of the endemicity. The children parasitic index, which was between 40 to 80% according to the localities in 1967, fell to 10% or less in 1991 and 1992. Finally, the incidence of clinical cases, calculated on a cohort of 100 children was only 4% in 1992, which is very low for an African endemic country. We conclude that drought and human activities have modified the environment such that malaria endemicity has seriously decreased. However, the risk of epidemic remains with the eventual occurrence of heavy rains. Therefore a surveillance of the area is needed to prevent a future epidemic.
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PMID:[Drought and malaria decrease in the Niayes area of Senegal]. 877 44

To optimize the funds devoted to health care, and to objectively assess the tools used in monitoring patients with cerebral malaria, we determined two parameters, care charges and direct costs due to hospitalization. During this longitudinal study conducted at the Albert Royer Pediatric Hospital in Dakar from October 15, 1991 to October 15, 1992 with 76 cases, malaria represented 5.2% of the febrile cases and 3.4% of the hospitalized cases. The lethality rate was 3.4%. Clinical features were not correlated with care charges and thus were not good indicators of worker's labor. The average cost of a cerebral malaria hospitalization was estimated at 35,710 F CFA (In October 1992, 1 F CFA = 0.02 FF). This cost is very high depending the limited resources of the region. Rapid and proper treatment of malaria cases may lead to a significant reduction of costs.
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PMID:[Care charges and direct costs related to hospitalization of Senegalese children with cerebral malaria. Study of 76 cases in the Albert-Royer Hospital in Dakar in 1991-1992]. 877 46


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