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Query: UMLS:C0024530 (malaria)
 44,886 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We here reported two Japanese cases of mixed infections of plasmodium species, whose DNAs were detected using the PCR test. One case was a 31 year-old male, who presented fever and fatigue, and had a travel history to Kenya, Cameroon and Indonesia. Smear test of his peripheral blood found the presence of Plasmodium vivax, while nested-PCR diagnosis detected the DNAs both P. vivax and Plasmodium malariae. The other was a 54 year-old female suffering from general fatigue. She had been treated with chloroquine for falciparum malaria in Indonesia two weeks before. Malaria antigen test showed positive although no Plasmodium organisms were found in the smear test. The nested PCR detected the DNA of Plasmodium ovale in addition to that of Plasmodium falciparum. In conclusion, the PCR test is helpful and useful for detection of mixed infections of Plasmodium species.
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PMID:[Two cases of mixed infection of malaria diagnosed by PCR method]. 1221 25

This report, presents a case of congenital malaria in an 8-hour-old female neonate. She responded well to oral chloroquine at a dose of 25 mg/kg in divided doses over a period of three days and was discharged home for follow-up, 24 hours after completion of the course of chloroquine. This case emphasized the need for routine screening for malaria in sick newborn infants in malaria endemic regions. This is particularly important in situations where clear evidence of sepsis cannot be established, either from history or physical examination of the sick newborn. Malaria and sepsis have similar clinical features in newborn infants.
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PMID:Congenital malaria in 8 hours old newborn: case report. 1222 66

A profile of Louise Lassonde, population advisor to the UN Conference on Environment and Development (UNCED) portrays her ethnic and educational background, her interests, and achievements. She was born a French Canadian near Montreal and earned a degree in anthropology with an emphasis on the ancient cultures of Peru. A second degree was earned in sociology and a Ph.D. in demography. In her investigations, it was discovered that there were few remnants of the old Indian culture remaining in the Andean highlands; Quechua and Spanish languages were learned in the process. Her professional responsibilities have included university teaching in development and demography in Montreal, development assistance work in Burundi, Rwanda, and eastern Zaire as regional director for a Canadian nongovernmental organization, and consultancy activities for UNICEF and UNFPA. As a consultant, she was engaged in studying women and their ways of generating income and improving the quality of their lives. In 1989, her position was as country director to Togo and Benin within the UN Population Fund followed by a position in the UNCED secretariat in Geneva. Her field experience has contributed to a view that time is precious and that there is accountability for action or inaction. A little bit of effort can go a long way, i.e., improved management and information and good will. The assumption is that people have the will and desire to improve their own and their families as long as there is hope and freedom from a discouraging atmosphere. Lack of understanding can create tremendous barriers. The example is given of a man presenting with malaria at an African health center and not being treated because of his tribal affiliation; he died when medicine was within reach. Support must be provided in terms of health and education so that people can set the targets for themselves and develop creative solutions compatible with their own cultures. Her positive approach is visible in her insistence that population issues be included in preparatory documents. She helped prepare a chapter in Agenda 21, the draft action plan for the Earth Summit in Rio de Janeiro which established the principle of stabilization of world population.
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PMID:Encouraging self-development. Profile: Louise Lassonde. 1231 75

Thousands of women in developing countries depend on quinacrine as a simple, low cost, nonsurgical sterilization method. Few US reproductive health professionals know about quinacrine's family planning use. Since quinacrine cannot be patented, no pharmaceutical company can protect its financial investments in quinacrine. So none has asked the US Food and Drug Administration to approve it for contraception. US family planners question quinacrine's safety and efficacy, but supporters have access to much data showing that it is safe. Quinacrine is used to treat malaria, giardia, tapeworm, and lung cancer. When quinacrine is inserted into the uterus, it dissolves, migrates to the tube, and creates scar tissue that blocks the tube. 252 mg quinacrine once a month for 2-3 months is enough to induce scarring. None of 80,000 women who have used quinacrine pellets to effect nonsurgical sterilization died from quinacrine. The liquid form of quinacrine used as a sterilizing agent in the 1970s in Chile caused 3 deaths, toxic psychosis (i.e., intense mental irritability), cancer, and a failure rate of 2-6.7%. Researchers are still following the Chilean women to determine whether there is indeed an excess cancer risk. Even though laboratory studies showed that quinacrine is potentially toxic, teratogenic, and mutagenic, researchers in Texas still used it for clinical trials. A gynecologist contends that even if quinacrine proves to be toxic to humans, it benefits may outweigh risks, and thus it should be available in the US. A women's health advocate is concerned about quinacrine's potential carcinogenic risk, yet she is interested in a sterilization procedure without surgery. She also thinks that sterilization is a misnomer because of its high failure rates. Many people think that a population control policy drives proponents to push for quinacrine use. Its proponents say that it will save the lives of women, and that surgical sterilization places women at risk of death.
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PMID:Quinacrine pellets have potential for simple, low-cost female sterilizations. 1231 49

We report a 68-year-old woman with severe falciparum malaria contracted in Tanzania. She presented high parasitemia and was treated successfully with intravenous artesunate, a qinghaosu derivative, and aggressive supportive therapy. She developed hemolytic anemia and jaundice on day 11 and blood transfusion was required. This case illustrates that intravenous artesunate has excellent antimalarial activity with rapid efficacy and that no severe adverse effect but conventional aggressive supportive therapy is still important in the treatment of severe falciparum malaria.
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PMID:[Severe falciparum malaria with prolonged hemolytic anemia after successful treatment with intravenous artesunate]. 1232 18

A trained nurse and midwife explains the origin of her motivation to become involved in family planning and describes the people who have influenced and guided her, her training and experience, and lessons learned over the years. She learned much from her mother who, through ignorance and a lack of health care and quick intervention, lost many children. From the years of practice following her training in England, the author learned that services must be taken to the people and learned about using a community- based distribution approach to promote family planning instead of relying exclusively upon a hospital. It became clear that women could be trained about family planning as well as the causes of high infant mortality like malaria, convulsions, and diarrhea. 171 voluntary village health workers were thus trained in 1979 to provide family planning and treat common illness in Oyo State, easing the entry of family planning into the rural area. 264 male and female vendors in 39 markets in Oyo State were subsequently trained in 1985 to provide family planning education, treatment of common illnesses, oral contraceptives, condoms, foam, and referral for other methods. The author stresses the need, based upon her experience, to discuss menstruation and pregnancy, and the importance of antenatal care, postnatal care, and infant welfare in simple words and notions with families in Nigeria. Although families will not understand the notion of overpopulation, they will acknowledge the need to ensure a mother's health and survival. The author serves on the Technical Advisory Committee for Family Health International's Women's Studies Project.
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PMID:"In talking to people, simplicity is best". 1234 51

The case was a 28-year-old Japanese female who was considered to be infected with malaria in India. She manifested fever in Tokyo, Japan, and was brought to Toho University Hospital due to continuous high fever and severe thrombocytopenia. Ring forms at 11% of her RBCs and ICT Malaria P.f/P.v test was also positive for Plasmodium falciparum diagnosis. Not only the high parasitemia and delay of the diagnosis (6 days after the onset of fever), but also her DIC status required prompt and proper treatment. The diagnosis of severe malaria was strongly considered, and intravenous Artesunate (a qinghaosu derivative) was decided to be administered to the patient. After the four series of administration, mefloquine was subsequently given to prevent recrudescence. Parasite clearance time and fever clearance time were 24 hours and 108 hours, respectively. Thrombocytopenia was improved shortly after the treatment, but then anemia was once worsened with following gradual improvement. No other significant side effects were observed and no recrudescence occurred up to 8 months after her discharge. In Japan, very few cases treated with intravenous Artesunate were reported and our results showed its safe and excellent effect for a Japanese malaria patient.
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PMID:[A case of falciparum malaria successfully treated with intravenous artesunate]. 1244 49

The clinical case of one patient with fever of unknown origin, due to granulomatous hepatitis of tuberculous etiology was presented. The patient was a a 50-year-old woman, with 50 days illness characterized by chills, 39 degrees C fever and heavy diaphoresis. She had a record of seven malaria cases. She looked thin and pale at the initial physical examination. During the evolution, she developed pancytopenia, massive hepatosplenomegaly, jaundice, and anasarca. The patient underwent screening tests for infection, neoplasias, collagenosis, and granulomatous diseases. The laboratory tests showed transaminase-alkaline phosphatase dissociation, which led to the final diagnosis of tuberculosis, through the histological examination of the liver parenchyma. The specific treatment against tuberculosis caused remission of fever, ascites, and hepatomegaly and normalization of liver tests, with satisfactory clinical evolution.
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PMID:[Granulomatous tuberculous hepatitis as cause of fever of unknown origin]. 1252 48

Investigation has been made on the folk medicine and health care in Jingning Autonomous Prefecture of She ethnic group, the only of its kind in China. It is demonstrated that since the living condition is bad, the hygienic environment is very poor, epidemics like measle, malaria and venereal diseases are very prevalent, and a high incident area of hyperthyroidism. Since there are no special writing characters, She ethnic group spread their medical know - how by oral transmission. Collection of herbs and compounding of recipes are mainly through the family. Medicine of the She ethnic group has a long history, and the treatment of bone - injury, snake - bites and wind - pain are very unique. It has been found that there are 599 genuses, 199 families of herbs in She medicine with 1043 species; among them, 214 herbs are in common use, falling under 126 genuses. In addition, 7 new herbal plants are found, and 332 recipes collected. Currently, over 40 She physicians are practicing in the prefecture.
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PMID:[Investigation on folk medicine and health care of She ethnic group in Zhejiang province]. 1263 31

A case of congenital malaria infection has been studied in a 46-day old female Korean infant. Her mother suffered from malaria infection during pregnancy in Uppervolta, Africa, and returned to Korea at the 9th month of gestation for delivery. At 39 days of age, the clinical features characterized by fever, irritability, pallor, jaundice and hepatosplenomegaly were developed. The laboratory data revealed a hemolytic anemia with thrombocytopenia, hyperbilirubinemia and increased hepatic enzyme values. A peripheral blood smear demonstrated intraerythrocytic malarial parasites snd gametocytes of Plasmodium falcifarum. She was successfully treated with quinine sulfate (25 mg/kg/day in three doses for 5 days) and trimethoprim/sulfamethoxazole (8 mg/kg/day in two doses for 5 days) orally, and repeated blood smear had been negative for malaria. This report also signifies the frst description of congenital malaria in Korea imported from Uppervolta in Africa. A brief review of related literature was made.
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PMID:[A case of congenital malaria] 1289 Oct 34


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