Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0024523 (malabsorption)
 7,319 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Arterial thrombosis is very rarely described in patients with coagulation factors deficiency. We report the first case of superior mesenteric artery thrombosis of a normal mesenteric artery associated with protein S deficiency, causing massive mesenteric infarction with short bowel syndrome. Eight-month parenteral nutrition and definitive antivitamin K anticoagulation were required in this 72 year-old patient. The initial oral anticoagulant malabsorption disappeared a few months later as clinical and biological course improved. Rapid intestinal adaptation was probably consecutive to early enteral refeeding. The possibility of reintroducing antivitamin K despite initial inefficacy should be stressed, as well as the necessity of an exhaustive coagulation work-up in patients with mesenteric infarction.
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PMID:[Mesenteric arterial thrombosis in protein S deficiency]. 988 Dec 73