Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0024523 (malabsorption)
 7,319 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The authors present the case of 54-old man primary tubular acidosis coexisting with malabsorption syndrome. Deviation were: extension of QT interval, low level of potassium and calcium in the blood, perturbations of calcium metabolism and high level of PTH. Glucose, lactose and iron absorption curves were flat. The final diagnosis was given as a result of analysis of findings and literature. The patient underwent the vitamin D3, calcium and potassium preparations, hydrochlorotiazyd treatment. Megaloblastic anaemia was treated with vitamin B12 and folic acid. Such therapy gave considerable improvement in patient's general condition and normalisation of lab tests results. The authors try explain the etiopathogenesis of bones changes and high level of parathormone. They assume the attitude towards methods of therapy and necessary medicaments doses. Relationship between described syndromes remains inextricable. Roentgen image of ileum which suggests occlusion is still unexplainable. Described case seemed to be very interesting considering rarity of primary tubular acidosis and its coexistence with malabsorption syndrome.
Pol Merkur Lekarski 1996 Sep
PMID:[Primary distal renal tubular acidosis coexisting with malabsorption syndrome]. 913 90

The disease is characterised by cobalamin (Cbl) deficiency in children 0-5 years old, causing failure to thrive, infections, megaloblastic anaemia, neuropathy, and mild general malabsorption; slight proteinuria is common. Cbl injections produce remission, but Cbl malabsorption and proteinuria persist. About 250 cases have been reported. Dogs also have it. The heredity is autosomal and recessive. The physiological and pathological absorption mechanisms are described: Cbl liberated from food by digestion is first bound to haptocorrin, but in the intestine it is transferred to intrinsic factor. In the ileum the complex attaches to a receptor on the enterocytes; this requires neutral pH and Ca2+. The receptor is a membrane-bound glycoprotein consisting of multiple subunits. The receptor-ligand complex is endocytosed and degraded in lysosomes, and the vitamin is transferred to transcobalamin which carries it to tissues. The same receptor is strongly expressed in the kidneys, but urine also contains its activity which can be assayed for diagnosis. The basic lesion is an error in the ileal receptor. In the affected dogs the synthesised receptor is retained intracellularly. Urine and ileal biopsies from human cases contained little receptor but it had conserved affinity for the ligand. Recently examined Arab patients did not excrete reduced amounts of the receptor. Apparently, the disease has subsets, such as different structural errors in the receptor and possibly faulty transport inside the enterocyte. The cause of the proteinuria is unknown but kidney damage due to severe Cbl deficiency and an error in a multiligand renal receptor are among the possibilities.
Acta Biochim Pol 1997
PMID:Selective cobalamin malabsorption and the cobalamin-intrinsic factor receptor. 958 52

The paper presents two cases of malabsorption syndrome in broiler chickens. The results indicate that the etiological factor appears to be the virus agent which causes necrosis in extra-excretional parts of the pancreas. During the course of the disease disorders in the enzymatic activity of gammaglutamyltransferase, leucylaminopeptidase and alanylaminopeptidase were observed. It consequently leads to the deterioration of intestines digestion and resorption of feed components. Application of Selcewet-Polfa to the diseased birds improved the health of the birds, morphological picture of peripheral blood and mineralisation of thigh bones. No radical improvement in the compensation of the final body weight was recorded.
Arch Vet Pol 1993
PMID:Further studies on the etiopathology of malabsorption syndrome in broiler chickens. 1018 83

It is generally accepted that the abdominal angina develops only when at least two of the three splanchnic vessels-mesenteric arteries and the celiac trunk exhibit a critical obstruction. That common opinion does not, however, take into account anatomical variants of arteries supplying the blood to the intestines. We present a case of a wasted, 40 year old male with a wide spread arteriosclerosis and postprandial pain. The ultrasound examination revealed total occlusion of the superior mesenteric artery (SMA). Celiac trunk (CT) and inferior mesenteric artery (IMA) were patent. The ultrasound indicated that only one splanchic vessel was obstructed; the systemic disorder, the neoplasm, as well as the malabsorption were ruled out. An arteriography of the abdominal aorta and of splanchnic arteries confirmed patency of CT and IMA, also lack of flow in the SMA. Atypical origin of the middle colic artery originating from the bed of CT was also shown. Lack of collaterals between IMA and SMA, typically conducting a sufficient blood flow, resulted in a fully symptomatic abdominal angina. Symptoms were relieved following surgical revascularization.
Pol Arch Med Wewn 2000 Dec
PMID:[Advanced abdominal angina due to atherosclerosis with atypical celiac arteries]. 1142 65

The multimodal evoked potentials (visual, somatosensory and auditory brainstem) in 23 patients with malabsorption syndrome of different origin were investigated. The diagnosis of the disease was confirmed on the basis of histological examination and result of D-ksyloza test. The control group consisted of 30 healthy persons. Examination of visual evoked potentials revealed significant prolongation of latency of P 100 component in examined group in comparison with controls. Latency of N13 and N20 of somatosensory evoked potentials in patients with malabsorption syndrome were also significantly prolonged when compared to controls, otherwise transit time to cortex (TTC) was merely prolonged. Auditory brainstem potentials were also abnormal. Changes involved prolongation of latency of I, III and V responses and prolongation of interpeak latencies of I-III, III-V, I-V as well. The amplitudes of the examined evoked potentials between patients and controls did not differ significantly. On the basis of obtained results in was pointed out that different specific afferent systems are affected in patients with malabsorption syndrome what seems to be connected with vitamin's deficiency, especially B12 and E. Authors conclude that multimodal evoked potentials examinations are useful in the diagnosis and monitoring of the disease, specially in subclinical cases.
Pol Merkur Lekarski 2001 Dec
PMID:[Multimodal evoked potentials in malabsorption syndrome]. 1189 47

Psychiatric symptoms and psychological behavioral pathologies are common in patients with untreated coeliac disease. There are several case reports of coexistence of coeliac sprue and depression, schizophrenia and anxiety. Views on association between coeliac disease and psychiatric disturbances and results of the most important studies are discussed. Biological background is referred. Malabsorption and deficiency of aminoacids and vitamins implicate reduction of synthesis of neurotransmitters in the central nervous system. Psychiatric symptoms could also be linked to immunological disregulation in coeliac patients. Psychological pathologies do appear in treated and untreated coeliacs, the need of psychological support is stressed. Coeliac disease should be taken into consideration in patients with psychiatric disorders, particularly if they are not responsive to psychopharmacological therapy, because withdrawal of gluten from the diet usually results in disappearance of symptoms. In recent years, an increased incidence of subclinical/silent coeliac disease has been reported. Psychiatric symptoms and psychological behavioral pathologies could be the only clinical manifestation of coeliac disease, but the epidemiological aspects need further investigation.
Psychiatr Pol
PMID:[Psychiatric symptoms and coeliac disease]. 1229 86

In cystic fibrosis (CF), as a result of chronic pulmonary infections and digestive malabsorption, an imbalance between the production of reactive oxygen species and their inactivation by protective systems is observed. This may cause impairment of cell metabolism and oxidative injury. The aim of this study was to examine whether markers of oxidative damage to protein (protein carbonyls) and lipids (malondialdehyde) may be modified in cystic fibrosis patients with pancreatic insufficiency. We have found that mean concentration of plasma protein carbonyls was 0.835 nmol/mg protein (the range of 0.31-1.71 nmol/mg protein) in CF patients (n = 57) and was higher by 30% than that in controls (n = 20). Plasma concentration of malondialdehyde (MDA) was 2.98 mumol/l in the range of 1.23-4.77 mumol/l. Among fifty seven patients studied, in 30 children MDA level was elevated above the highest values observed in the healthy group (2.80 mumol/l). Total radical-trapping antioxidant parameters (TRAP) amounted to 629 mumol/l and 735 mumol/l in CF patients and control, respectively. The difference was statistically significant (p < 0.005). The obtained results indicated that in CF patients oxidative stress caused oxidative modification of proteins and peroxidation of lipids which was accompanied by lowering of antioxidant protection. These results indicate that certain CF patients (especially those with exocrine pancreatic insufficiency) are susceptible to oxidative damage, therefore it seems that an adequate and balanced diet is essential for achieving and maintaining normal antioxidant defenses.
Pol Merkur Lekarski 2002 Aug
PMID:[Markers of oxidative damage in blood of children with cystic fibrosis]. 1242 Mar 42

It had been suspected for many years that mother's periconceptional diet may have a role in the causation of birth defects. Over the past 10 years, many studies have reported that women who used multivitamins periconceptionally had a reduction in risk for offspring with orofacial cleft. This study was aimed to establish vitamin E status in Polish mothers of children with isolated cleft lip. 37 mothers of children with cleft lip (CL) and 67 women who gave birth to healthy children were studied. All participants were healthy women without symptoms of malabsorption. Levels of alpha-tocopherol in plasma and erythrocytes were determined by high-performance liquid chromatography. There was no differences between mean plasma alpha-tocopherol level in mothers of children with birth defect and mothers of healthy children (17.81 +/- 4.81 micromol/l vs 19.44 +/- 5.01 micromol/l; p>0.05). It is believed that the ratio of alpha-tocopherol to total cholesterol is more useful as a measure of vitamin status than the a-tocopherol level alone. In mothers of children with CL plasma alpha-tocopherol to total serum cholesterol ratio was statistically lower compared to those in the control group (3.35 +/- 0.88 micromol/mmol vs 3.89 +/- 0.79 micromol/mmol; p<0.02). Ratio of alpha-tocopherol level in erythrocytes to total serum cholesterol was also lower in mothers of children with CL (0.38 +/- 0.06 micromol/mmol vs 0.48 +/- 0.10 micromol/mmol; p<0.05). Our results suggested that vitamin E may play a role in prevention of orofacial clefts.
Pol Merkur Lekarski 2004 Jul
PMID:[Vitamin E status in mothers of children with cleft lip]. 1555 5

Coeliac disease is characterized by life-long gluten intolerance. There are a wide variety of clinical presentations, which range from severe diarrhoea and weight loss to asymptomatic forms. The primary treatment for coeliac disease is the removal of gluten from the diet to prevent both immediate and long-term complications. The case of 16-year-old girl with coeliac disease was presented. At the age of 2 years the patient with impaired growth and abnormal stools was suspected to have coeliac disease. She experienced symptomatic improvement on gluten-free diet, but after 3 years the treatment was discontinued. The patient denied gastrointestinal or skin problems. At the age of 14 years Raynaud's phenomenon was observed for the first time. Two years later episodes of Raynaud's phenomenon involved all fingers and toes. Body mass index (BMI) was 23.8 kg/m2. Levels of free-carnitine, tocopherol, vitamin B12 were below normal limits and homocysteine level was increased. Antiendomysial IgA, antireticulin IgA, antigliadin IgA and IgG antibodies were positive. The duodenal mucosa showed total villous atrophy. Gluten free-diet and multivitamin supplementation provided some benefit in reducing Raynaud's phenomenon. The patient's well being has improved markedly. Atypical coeliac disease is usually seen in adolescents and adults in whom features of overt malabsorption are often absent. In cases of health problems occurring in persons with history of malabsorption syndrome in childhood suspicion of coeliac disease should be heightened and appropriate evaluation undertaken.
Pol Merkur Lekarski 2004 Nov
PMID:[Atypical celiac disease in an adolescent girl--case report]. 1575 40

We describe here a case of a 42-year-old male patient with severe hipogammaglobulinemia primary hypoparathyroidism and hypogonadism, various G1 disorders, malabsorption syndrome, anemia and recurrent severe sinopulmonary infections. We present also difficulties and limitations relating to diagnosis of common variable immunodeficiency and shortly present review of literature.
Pol Arch Med Wewn 2005 Nov
PMID:[Primary hypoparathyroidism and hypergonadotropic hypogonadism in a male patient with common variable immunodeficiency. A case report]. 1678 8


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