Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0024523 (malabsorption)
 7,319 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Malabsorption of rat and alpha-tocopherol was induced in rats by feeding cholestyramine and the effect of Tween 80 and Pluronic F 68 was assessed. Tween 80 did not influence the malabsorption of fat or alpha-tocopherol. Pluronic F68 did not change alpha-tocopherol absorption but did significantly improve fat absorption. The proportion of radioactivity remaining in the liver 5 days after a labelled dose of alpha-tocopherol was increased when Tween 80 or Pluronic F68 was present, perhaps indicating increased absorption via the portal vein. Serum cholesterol levels were not affected by the different diets. The greatly increased excretion of faecal bile salt on dietary cholestyramine was unchanged by the detergents.
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PMID:Effect of non-ionic detergents on the absorption of fat and alpha-tocopherol in the rat. 122 59

Several factors play a role in the cause of malabsorption in CF. Besides the enzyme deficiency in the secretion of the exocrine pancreas, decreased bile-salt concentration in the gut may also be an important factor in the fat malabsorption. The contribution to the fat absorption by other lipases, such as lingual lipase and gastric lipase, remains to be proved. The therapeutic measures are only partly effective because of the breakdown of swallowed enzymes by gastric acid. Some improvement is reached by using a new acid-resistant coating for the enzyme supplement. Newly developed and essential for its success is the application of small coated particles to prevent retention in the stomach, and the easy breakdown of the coating in an alkaline solution. The treatment of the bile salt deficiency has not been successful until now. A trial with additional Tween 80, with the option of supplementing the detergent activity which was found to be successful in Crohn disease, was without marked success.
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PMID:Problems in the treatment of malabsorption in CF. 386 58

Bioavailability of diltiazem was investigated in rats with the neomycin induced malabsorption syndrome in presence of surfactants. Tween 80, sodium lauroyl sulphate and lecithin were added under their critical miscellar concentration levels. Increases of diltiazem bioavailability (in the range of 5-29%) promoted by additions of the surfactants were observed.
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PMID:Enhancement of diltiazem bioavailability by traces of surfactants in rats after neomycin-induced malabsorption syndrome. 983 46