Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0024523 (
malabsorption
)
7,319
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Proton pump inhibitors are potent drugs producing profound suppression of gastric acid secretion. Consequently, they are highly effective at treating acid-related disorders. There have been concerns that the suppression of gastric acid will alter the bacterial flora of the upper gastrointestinal tract and lead to complications such as cancer, enteric or other infections and
malabsorption
. Studies have confirmed that proton pump inhibitors do alter the bacterial population but present evidence indicates that this only rarely leads to clinical disease. As with all drugs, proton pump inhibitors should only be used for disorders shown clearly to benefit from the therapy and where the benefits will outweigh the small risks associated with them. Further research to more fully quantify the risk associated with
PPI
therapy is required.
...
PMID:Review article: proton pump inhibitors and bacterial overgrowth. 1669 19
We describe a case of a 65-year-old woman admitted to the hospital for suspected of epileptic crisis. She was affected by diabetes and hiatal hernia for which she was taking Proton Pump Inhibitors (
PPI
s
) for about 8 years. She showed hypocalcaemia, hypomagnesaemia, hyperparathyroidism and severe hypovitaminosis D. We exclude
malabsorption
and magnesium loss. After restored vitamin D levels, stopped use of
PPI
, start calcium and magnesium supplementation normal values of the ions were restored. This case underlies the importance of evaluate magnesium routinely, other than calcium and vitamin D, and use
PPI
more carefully.
...
PMID:Is this a seizure? 2874 May 32
Several adverse effects associated with long-term
PPI
therapy have been reported. These potential risks or side effects have included hypergastrinemia, carcinoid formation, devel- opment of gastric cancer, bacterial overgrowth, Clostridium difficile infection, pneumonia, bone fracture and
malabsorption
of vitamin B12 and iron. I explain each of these adverse events based on the guideline for GERD in both Japan and US, multiple meta-analyses and systematic review previously published.
...
PMID:Potential risks associated with long-term PPI use. 3056 48
