Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0024523 (malabsorption)
 7,319 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

There is enormous potential for drug interactions in patients who, today, often receive many drugs. Antibiotics are prominent amongst the groups of drugs commonly prescribed. Many interactions take place at the absorption stage. Antacids and antidiarrhoeal preparations, in particular, can delay and reduce the absorption of antibiotics such as tetracyclines and clindamycin, by combining with them in the gastrointestinal tract to form chelates or complexes. Other drugs can affect gastric motility, which in turn often controls the rate at which antibiotics are absorbed. Some broad spectrum antibiotics can alter the bacterial flora of the gut which may be related to malabsorption states. The potentiation of toxic side effects of one drug by another is a common type of interaction. Antibiotics which are implicated in this type of interaction are those which themselves possess some toxicity such as aminoglycosides, some cephalosporins, tetracyclines and colistin. Some of the most important adverse interactions with antibiotics are those which involve other drugs which have a low toxicity/efficacy ratio. These include anticoagulants such as warfarin, anticonvulsants such as phenytoin and phenobarbitone and oral antidiabetic drugs like tolbutamide. Risk of interaction arises when the metabolism of these drugs is inhibited by liver microsomal enzyme inhibitors such as some sulphonamides and chloramphenicol, or is enhanced by enzyme inducers such as rifampicin.
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PMID:Adverse antibiotic drug interactions. 699 91

The causes and clinical picture of osteopenia and osteoporosis were analyzed in 13 children (7 girls and 6 boys aged 6-15 years of life, mean age 10.2 years). The diagnosis was based on X-ray and densitometric studies. Upper gastrointestinal tract diseases were noted in 7 patients (one child received additional anti-epileptic drugs) and 5 had juvenile osteoporosis. Children with Gl tract diseases and these on anti-epileptic management may develop osteoporosis and osteopenia as a consequence of vitamin D3 deficit and calcium malabsorption leading to hypocalcemia and secondary hyperparathyroidism.
Endokrynol Diabetol Chor Przemiany Materii Wieku Rozw 1999
PMID:[Causes and clinical picture of osteopenia and osteoporosis in children]. 1281 89

The assessment of body composition and energy requirements is important for the nutrition of healthy and pathological states such as gastrointestinal disorders, which are known to be associated with abnormalities in body composition among persons with malnutrition and malabsorption. Careful monitoring of body composition is thus recommended for assessing body water compartments, predicting caloric needs and physical performance, and evaluating the development of muscle mass in persons with malabsorption. In the present review we briefly describe the basic body composition models and various techniques used for their assessment and discuss the utility of measuring caloric requirements in persons with gastrointestinal disorders. Assessing body composition may improve the prognosis of malnutrition caused by gastrointestinal disorders and may be useful in monitoring diet treatment.
Acta Diabetol 2003 Oct
PMID:Assessing body composition in gastrointestinal disorders. 1461 60

Fibrocalculous pancreatic diabetes (FCPD) is an uncommon form of diabetes that occurs as a result of chronic calcific pancreatitis, in the absence of alcohol abuse. The disease is restricted to tropical regions of the world, and southern India has the highest known prevalence of FCPD. The typical patient with FCPD is a lean adolescent or young adult of either sex, presenting with history of recurrent bouts of abdominal pain and steatorrhea. Demonstration of large, discrete pancreatic calculi by plain radiographs or ultrasonography of the abdomen is diagnostic. While the exact etiology of FCPD is unknown, genetic, nutritional and inflammatory factors have been hypothesized to play a role. Diabetes in FCPD is often brittle and difficult to control; most patients require multiple doses of insulin for control of glycemia. However, in spite of high blood glucose levels, patients rarely develop ketosis. Malabsorption responds to pancreatic enzyme supplementation. Surgical removal of stones is indicated for symptomatic relief of intractable pain. While patients with FCPD develop microvascular complications as frequently as those with type 2 diabetes, macrovascular disease is uncommon. Development of pancreatic malignancy is the most dreaded complication and should be suspected in any patient who complains of weight loss, back pain or jaundice.
Acta Diabetol 2015 Feb
PMID:Fibrocalculous pancreatic diabetes (FCPD). 2539 47