Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0024523 (malabsorption)
 7,319 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The presence of medium-chain fatty acids in dietary fatty acid as well as the triacylglycerol structure may influence the absorption and lymphatic transport of fatty acids. We compared the lymphatic transport and recovery of fatty acids from four intragastrically administered fats based on rapeseed oil and decanoic acid in two rat models of normal absorption and malabsorption, respectively. The fats were: 1) a fat with a regiospecific structure, 2) a similar fat but with a random distribution of fatty acids in the triacylglycerol molecule, 3) a physical mixture of tridecanoin and rapeseed oil and 4) rapeseed oil as control. Lymph samples were collected for 24 h. Significantly higher recoveries were observed of total fatty acids, oleic acid, linoleic acid and linolenic acid from the specific oil in malabsorbing rats and of linoleic acid in normal rats fed specific oil compared with those fed rapeseed oil. Furthermore, the recoveries of oleic acid and linolenic acid from the specific oil in normal rats were higher than those from the other oils. In malabsorbing rats, the transport of all fats was approximately 90% less than that of normal rats. The present study demonstrates improved hydrolysis and absorption of the specific oil compared with the other oils examined both in rats with normal absorption and in rats with malabsorption.
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PMID:Structured lipids improve fat absorption in normal and malabsorbing rats. 1105 24

Fish oils contain essential polyunsaturated fatty acids of the n-3 family. In fat malabsorption the n-3 fatty acids are poorly absorbed. Absorption may be improved by modifying the fatty acid profile of fish oil through interesterification with medium chain fatty acids. We examined the absorption of fish oil interesterified with decanoic acid in rats with normal- and malabsorption compared to a physical mixture and the fish oil itself. The interesterified fats were: 1) a regiospecific fat with decanoic acid located mainly in the sn1/3-positions and a long chain fatty acid from fish oil in the sn2-position, 2) a fat with a random distribution of fatty acids in all positions of the triacylglycerol. The main mesenteric lymph duct was cannulated for collection of lymph. In the malabsorbing rats the common bile duct was cannulated as well to divert both pancreatic juice and bile. The fatty acid composition in lymph samples collected for 24 hours was determined. Accumulated transport of n-3 fatty acids from fish oil was improved in malabsorbing rats and recoveries of fatty acids after 24 hours were improved in both rats with normal- and malabsorption administered the randomized fat compared to fish oil.
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PMID:Lymphatic transport of fat in rats with normal- and malabsorption following intake of fats made from fish oil and decanoic acid. Effects of triacylglycerol structure. 1144 84