Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0024523 (malabsorption)
 7,319 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Since the beginning of this century, the concept of tropical neuromyelopathy (T. N. M.) was progressively elaborated in tropical areas. This disorder is constituted by three main clinical syndromes (e.g.: polyneuropathy, spastic paraplegia, ataxia). Abnormal clinical, electrophysiological and pathological features, observed in all clinical forms argue in favor of a diffuse pathobiological process of the nervous system. The association with positive HTLV-1 serology, has recently induced a great interest for the spastic forms of T. N. M. Tropical spastic paraplegia tend to be individualized. This attitude differs from the global concept of T. N. M. which allows gathering similar clinical syndromes. This T. N. M. group should be kept intact until the discovery of new etiologies. Toxic (manioc, lathyrism) or deficiency (hypovitaminosis, malabsorption) causes are incriminated. Otherwise etiologies are unknown.
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PMID:[The concept of tropical neuromyelopathy]. 290 Dec 97

Tropical myeloneuropathies include tropical ataxic neuropathy and tropical spastic paraparesis. These disorders occur in geographic isolates in several developing countries and are associated with malnutrition, cyanide intoxication from cassava consumption, tropical malabsorption (TM), vegetarian diets, and lathyrism. TM-malnutrition was a probable cause of myeloneuropathies among Far East prisoners of war in World War II. Clusters of unknown etiology occur in India, Africa, the Seychelles, several Caribbean islands, Jamaica, and Colombia. Treponemal infection (yaws) could be an etiologic factor in the last two. Tropical myeloneuropathies, a serious health problem, are multifactorial conditions that provide unsurpassed opportunities for international cooperation and neurologic research.
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PMID:Tropical myeloneuropathies: the hidden endemias. 299 14