Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0024523 (malabsorption)
 7,319 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Results of clinical and laboratory dynamic examination of the nervous system in 95 children with intestinal malabsorption are reviewed. The basic neurological syndromes accompanying this ailment are specified. These are: an astheno-neurotic and neurosis-like; a hypertensive-hydrocephalic; a syndrome of motor disturbances (with the secondary neuromuscular syndrome being the leading in its structure); a syndrome of visceral dysfunctions; a convulsive syndrome and a syndrome of retardation of the age, speech, and psychomotor development. A dependence of the neurological disturbances on the form and the course of the underlying disease, character of metabolic disorders and age of the sick children is demonstrated. Peculiarities of the emotional and volitional spheres of the children examined are disclosed. Analysis of the neuropsychic development of sick children allows a conclusion that therapeutic and correcting measures aimed at compensation of the neurological disturbances revealed should be included as early as possible into the complex of pathogenetic therapy.
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PMID:[Changes in the nervous system in children with malabsorption syndrome]. 743 32

A 49-year-old man presented with neurosis, hyperpigmentation of the skin, and depigmentation of the hair. On examination, hyperpigmentation was observed on the oral mucosa and the skin of the forearms, elbows, palmar creases and periunguinal area, knees, and feet. He had megaloblastic anemia with a low serum level of vitamin B12 due to malabsorption resulting from a gastrectomy 10 years previously. His hyperpigmentation was resolved with vitamin B12 supplementation. Histology showed an increase of melanin in the basal layer. In electron microscopic study, many melanosomes were observed in melanocytes and surrounding keratinocytes. We consider that the dominant mechanism of hyperpigmentation due to vitamin B12 deficiency is not a defect in melanin transport but is rather an increase in melanin synthesis.
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PMID:Generalized hyperpigmentation of the skin due to vitamin B12 deficiency. 1143 69