Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0024523 (malabsorption)
 7,319 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

This report deals with a 26-year-old white woman exhibiting signs of both Kwashiorkor (marasmus, pallor, hypopigmentation of hair and hepatomegaly) and acrodermatitis enteropathica (eczematous dermatitis predominantly on acral areas). Clinical and laboratory examinations excluded malabsorption syndrome and glucagonoma syndrome and revealed hypoproteinemia and marked zinc deficiency. Psychiatric examination disclosed anorexia nervosa. Substitution therapy led to rapid clearing of the skin lesions.
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PMID:Kwashiorkor-like zinc deficiency syndrome in anorexia nervosa. 9 54

A case report is given of a 73 years old woman suffering from Whipple's disease. Intermittant polyarthralgias, diarrhea, weight loss and laboratory signs of malabsorption had been present for 6 years, when diagnosis was established by biopsy: pathognomonic PAS-positive macrophages were demonstrated in the duodenal mucosa. A complete remission of the disease could be achieved after 100 mg of doxycycline had been administered continuously for a year. Some special details of the course of Whipple's disease in the higher age group are discussed.
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PMID:[Whipple's disease in an elderly person (author's transl)]. 9 35

Following a single, oral dose of Bacillus cereus (2 X 10(8) bacteria) in vitro intestinal absorption of D-glucose, D-galactose, L-arginine, L-histidine, L-ornithine and L-proline in young mice (aged 2--3 1/2 months) decreased. Malabsorption of D-glucose was dose- and time-dependent. Impaired absorption of D-glucose occurred throughtout the length of the small intestine, particularly distally. Following hydrolysis of D-maltose at the brush border, D-glucose absorption in infected mice and that of the untreated controls was similar. Using D-glucose, fluid transfer in the infected intestine and that of the controls was alike. Although slightly lower, fluid transfer in the infected intestine using the other solutes was not significantly different compared with the controls. Glucose-dependent and glucose-independent intestinal fluid transfer in infected animals was like that of the controls. Using old infected mice (aged 8--9 months) intestinal absorption of D-glucose and L-histidine was unchanged compared with young mice. The fresh small intestinal weight in infected mice and the controls was alike. Changes in the histology of the small intestine in young infected mice were small and inconsistent.
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PMID:Bacillus cereus-induced malabsorption in young mice. 9 13

Three cases of severe anorexia are reported. It results in a strong protein malabsorption with hepatic steatosis and in a syndrome of mental depression which needed the re-establishment of the intestinal-continuity. Although a mild post-operative anorexia is regular and contributes to the weight loss, massive anorexia must be considered as a new and redoubtable unpredictible complication of the surgical treatment for obesity, which may hinder the intestinal adaptation and increase the protein malabsorption.
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PMID:[Anorexia: a redoubtable complication of the surgical treatment for obesity after jejuno ileal by-pass (author's transl)]. 9 23

Thirty-six hospital in-patients in London had breath-hydrogen concentrations measured after 50 g lactose were given orally; in 23 or them serial blood glucose concentrations were also estimated. Eight had tropical malabsorption (TM), 14 were Europeans with no detectable disease (normal group) and 14 who also had no detectable disease, were from ethnic groups known to have a very high incidence of genetically determined adult hypolactasia (hl). In 21 of them breath-hydrogen concentrations were also measured after 33.5 g of lactulose were given orally. There was a good inverse correlation between breath-hydrogen production and blood-glucose rise after lactose. Correlations between the first appearance of hydrogen (T) and the area under the hydrogen curve between 0 and 120 min (A) were inversely significant both for lactose and lactulose. Mean T was earlier and mean A greater for lactose compared with lactulose. Correlation between individual values for A after lactase and after lactulose was significant. Indirect measurements of lactase are of no value in either detecting or assessing the severity of TM; that is largely due to the very high incidence of HL in individuals exposed to that disease.
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PMID:Breath hydrogen concentrations after oral lactose and lactulose in tropical malabsorption and adult hypolactasia. 9 20

Oral iron and zinc tolerance tests were performed in 12 patients between 8 and 21 years of age, with iron deficiency anemia and geophagia. Decreased iron and zinc absorption were detected respectively in patients against the elevated absorption curves in control subjects. Iron and zinc malabsorption may be an additional feature of the syndrome characterized by geophagia, iron deficiency anemia, hepatosplenomegaly, hypogonadism and dwarfism observed in Turkey and Iran.
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PMID:Decreased iron and zinc absorption in Turkish children with iron deficiency and geophagia. 9 53

We have studied 5 infants with persistent severe diarrhea from birth and marked abnormalities of absorption associated with failure to thrive leading to death in 4 infants. Three had siblings who died and a sibling of a 4th is ill at present, all with a similar illness; 2 were the products of consanguinous marriages. Exhaustive investigation failed to identify a recognized disease entity in any patient. Steatorrhea, sugar malabsorption, dehydration, and acidosis were severe in all patients, whatever the diet fed. Total parenteral nutrition was used, but excessive stool water and electrolyte losses persisted even when nothing was fed by mouth. There was no evidence of a hematological or consistent immunological defect in any infant and no abnormalities of intestinal hormones were noted. In the duodenal mucosa of all infants we saw similar abnormalities characterized by villus atrophy, crypt hypoplasia without an increase in mitoses or inflammatory cell infiltrate in the lamina propria and in villus enterocytes absence of a brush border, increase in lysosome-like inclusions, and autophagocytosis. In 3 infants studied by marker perfusion of the proximal jejunum we found abnormal glucose absorption and a blunted response of Na+ absorption to actively transported nonelectrolytes; in 2 there was net secretion of Na+ and H2O in the basal state. Our patients evidently suffered from a congenital enteropathy which caused profound defects in their capacity to assimilate nutrients. The similar structural lesion seen in the small intestinal epithelium of all of our cases undoubtedly contributed to their compromised intestinal function, but the pathogenesis of this disorder, if indeed it is a single disease, remains obscure.
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PMID:Familial enteropathy: a syndrome of protracted diarrhea from birth, failure to thrive, and hypoplastic villus atrophy. 10 Mar 67

Currently, 6 agents of viral gastroenteritis with properties similar to the Norwalk agent have been described. These are the Hawaii, Montgomery County, W, Ditchling, and Cockle agents, as well as the Norwalk agent. These agents are 25 to 27 nm in diameter, are nonenveloped, and have a buoyant density of 1.38 to 1.40 g/cc in CsCl. Multiple antigenic types exist among these agents. These particles have been detected by immune electron microscopy in feces of acutely ill patients. None has been successfully cultivated in vitro, and suitable animal models of disease do not exist. Studies in volunteers indicate that acute infection is associated with a reversible histopathologic change in the jejunal mucosa and with transient malabsorption. Pathogenesis of these changes remains unknown. Other similar agents will likely emerge from ongoing studies.
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PMID:Norwalk agent-like particles associated with gastroenteritis in human beings. 10 Apr 81

The human body badly tolerates the extensive loss of the small intestine by resection. Malabsorption of various substances is followed by severe deficiency symptoms. In recent years a longer survival with a satisfactory general condition was achieved by intensive postoperative care and adequate diet--in our own cases even in adults and in old age.
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PMID:[Surgical and dietetic problems of subtotal resection of the small intestine in adults (author's transl)]. 10 16

While deficiences of trace metals and essential fatty acids are rare in humans fed orally, the widespread use of total parenteral nutrition (TPN) has increased the likelihood of encountering these deficiences. A 14-year-old boy, with total villous atrophy of the small intestine, suffered from severe malnutrition and was placed on a conventional TPN regimen. Although not immediately recognized, he rapidly developed deficiencies of zinc, copper and essential fatty acids. Careful monitoring of the course of the illness and the responses to sequential treatments with zinc, lipid, and copper given intravenously allowed examination of the effects of the deficiencies on skin, intestine, liver, and hemopoietic systems and helped to establish normal requirements for the metals. The progress of the illness suggested that patients with intestinal malabsorption may be especially at risk of developing some of these lesser known complications of TPN.
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PMID:Trace metal and essential fatty acid deficiency during total parenteral nutrition. 10 88


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