Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0024523 (malabsorption)
 7,319 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A malignant lymphoma of the small bowel developed in a 75-year-old woman who had severe late-onset hypogammaglobulinemia with intestinal malabsorption and nodular lymphoid hyperplasia. The tumor arose in the midst of the abnormal lymphoid follicles and appeared to be of B-immunoblastic type. Immunoperoxidase staining, however, failed to reveal immunoglobulins in the tumor cells. In vitro immunologic studies showed that immunoglobulin production by the patient's peripheral lymphocytes had decreased and that this decrease was mediated by hydrocortisone-sensitive suppressor cells. These findings suggest that nodular lymphoid hyperplasia of the intestine in the context of severe immunodeficiency is a premalignant condition.
 ...
PMID:Immunoblastic lymphoma of small intestine complicating late-onset immunodeficiency. 689 59

A 45-year-old woman with T-cell lymphoma is reported. Enlargement of the peripheral lymph nodes was not observed. Splenectomy was performed for hypersplenism and during the operation the mesenteric and retroperitoneal lymph nodes were found to be greatly enlarged. Three years after the diagnosis of lymphoma malabsorption syndrome developed. After 5 years sudden clinical deterioration appeared, with loss of reaction to effective treatment given as yet. Conversion of the predominating lymphocyte subpopulation from T to B cells was observed owing to repeatedly done monitoring of peripheral blood lymphocytes. The pattern of the newly developed lymphoma was that of a highly malignant B-cell proliferation. The possible mechanisms of the conversion discussed by the authors include: simultaneous proliferation of B and T populations of lymphocytes, B-cell lymphoma induction by chemotherapy, and infection by Epstein-Barr virus.
 ...
PMID:[Transformation of type T lymphoma into type B lymphoma]. 697 55

Malignant lymphoma involves the gastrointestinal tract as a primary or secondary in the course of disseminated lymphoma. Although primary lymphoma has received the most attention in the literature, secondary lymphoma of the gastrointestinal tract is much more common. The gastrointestinal manifestations and complications are a common problem and there is a lack of information as to diagnosis, management and prognosis. Intensive application of currently-available diagnostic techniques including radiology, cytology, endoscopy, biopsy and gastric secretory studies should be pursued for the evaluation of patients with lymphoma. The management of the multiple gastrointestinal complications such as monilial esophagitis, hemorrhagic gastritis, stress erosions, intestinal perforation, diarrhea, malabsorption and radiation damage that may then affect the gastrointestinal tract in the course of malignant lymphoma or its treatment requires very careful supportive management. Each modality of tretment for lymphoma may be associated with a variety of complications which compromise the structure and function of the gastrointestinal tract and which may be at times more devastating than the underlying neoplasm. Early recognition and active treatment of these complications is vital.
 ...
PMID:The gastrointestinal manifestations and complications of malignant lymphoma. 699 13

Two patients with idiopathic chronic ulcerative enteritis (ICUE) having malabsorption, subtotal villous atrophy and non-specific small intestinal ulceration are presented with emphasis on the radiological features. No improvement was shown morphologically following gluten withdrawal. The literature on this condition is reviewed. Obstruction, perforation and melaena are serious complications and the prognosis is poor; only 11 out of 31 reported cases survived. Differentiation from coeliac disease, Crohn's disease and primary intestinal lymphoma is discussed.
 ...
PMID:Radiology in Idiopathic chronic ulcerative enteritis. 707 32

The screening value of the one-hour blood xylose test, corrected for body surface area, was prospectively studied in Saudi Arabian adults and children under investigation for suspected intestinal malabsorption. Sensitivity of discrimination between patients with and without upper small bowel disease was 91%, compared to 85% for the five-hour urine xylose test. Primary small bowel disorder was rare. In a three-year review, no cases of adult coeliac disease or tropical sprue were found. The most common causes of malabsorption were intestinal tuberculosis, abdominal lymphoma and immunoproliferative small intestinal disease. Despite its acceptability as an index of proximal small bowel function, the blood xylose test alone is an inadequate screening test for any of these conditions.
 ...
PMID:Intestinal absorption in Saudi Arabia: an evaluation of the one hour blood xylose test. 708 Jan 53

The case report is presented of a patient with gluten sensitive enteropathy who subsequently developed an intestinal non-Hodgkin lymphoma. When steatorrhoea or diarrhoea develops in a patient with abdominal lymphoma, these symptoms are often attributed to progression of the lymphoma or to chemotherapy of the lymphoma. Since there is an established relationship between gluten-sensitive enteropathy and intestinal lymphoma, the differential diagnosis of steatorrhoea or diarrhoea developing in the course of malignant intestinal lymphoma must include gluten-sensitive enteropathy as well. In the investigation for gluten-sensitive enteropathy HLA typing can be used as a screening test in addition to routine malabsorption tests and small bowel biopsy
 ...
PMID:[Gluten-sensitive enteropathy and intestinal non-Hodgkin lymphoma (author's transl)]. 708 Apr 98

It has been established that considerable blast-transformation and mitotic activity occurs among epithelial lymphocytes of untreated coeliac mucosa. This paper is concerned solely with the proliferative activity of epithelial lymphocytes (expressed as percentage "mitotic index") in the prospective diagnosis of coeliac disease, in comparison with other conditions such as lymphoma. Crohn's disease and immunodeficiency which are often associated with malabsorption and flattening of jejunal mucosa. The results demonstrate that a high mitotic index (greater than 0.2%) clearly distinguishes, and hence predicts, gluten-associated enteropathies (including dermatitis herpetiformis and malignant histiocytosis) from others in which gluten plays no aetiological role and where the mitotic index differs insignificantly from normal control mucosae (much less than 0.2%). Furthermore, it has been demonstrated that the mitotic index is raised in so-called "non-responsive coeliacs," thus suggesting that such patients may also be gluten-sensitive despite their subsequent failure to respond morphologically to dietary gluten restriction.
 ...
PMID:Studies of intestinal lymphoid tissue. IV--The predictive value of raised mitotic indices among jejunal epithelial lymphocytes in the diagnosis of gluten-sensitive enteropathy. 708 95

Three cases of follicular lymphoid hyperplasia extending to the whole length of small intestine are reported in three young adult patients of low economic status. The disease was revealed by chronic diarrhea with malabsorption and/or protein-losing enteropathy. In one patient, all transitional patterns were found between the hyperplastic follicles and a small intestinal multicentric centrocytic-centroblastic lymphoma. No abnormalities in humoral or cellular immunity were found in the three patients. In particular, serum immunoglobulins (except IgG in one case) and plasma cell populations of small intestinal lamina propria were normal. Diffuse follicular lymphoid hyperplasia of the small intestine in the absence of primary immunoglobulin deficiency appears to be a rare condition associated with (or leading to) intestinal malignant lymphoma in most cases. Patients usually belong to the same populations as those suffering from alpha-chain disease.
 ...
PMID:Diffuse follicular lymphoid hyperplasia of the small intestine without primary immunoglobulin deficiency. 709 Nov 67

Mucosal defects decrease digoxin absorption in patients with malabsorption syndromes. Since the intestinal mucosa can be damaged by cytostatic drugs, we investigated their effects on digoxin plasma levels and urinary digoxin excretion. In six patients with malignant lymphoma who received 0.8 mg beta-acetyldigoxin before and 24 hr after treatment with a combination of cyclophosphamide, oncovin, procarbazine, and prednisone (COPP) or cyclophosphamide, oncovin, and prednisone (COP), plasma digoxin concentrations were measured 0 to 8 hr after the dose and areas under the plasma concentration-time curves were calculated. In 15 patients on 0.3 mg of beta-acetyldigoxin daily, plasma glycoside concentrations and renal excretion were measured daily before and after COPP, COP, cyclophosphamide, oncovin, cytosine-arabinosine, and prednisone (COAP), or adriamycin, bleomycin, and prednisone (ABP) treatment schemes. The diminished steady-state glycoside plasma concentrations and daily renal glycoside excretion during the 24 to 168 hr after the cytostatic drug established reversible impairment of digoxin absorption. The delayed time to peak after a single dose of digoxin during cytostatic drug therapy shows that extent and rate of digoxin absorption are reduced. To maintain adequate control of digoxin therapy in patients treated with cytostatic drugs, plasma levels should be monitored.
 ...
PMID:Effects of cytostatic drugs on plasma level and renal excretion of beta-acetyldigoxin. 728 86

The peroral small intestinal biopsies of 5 patients with chronic malabsorption leading to a fatal course were examined retrospectively for the presence of abnormal (? premalignant) cells. Techniques employed for their identification included routine histology, immunofluorescence, immunohistochemistry (horseradish peroxidase) and electron microscopy. The biopsies of 3 other patients, 2 with known lymphoma and 1 with alpha chain disease were examined for any similarity in the ultrastructural appearances of abnormal cells and their immune cellular behaviour in these 2 groups of patients. Fine structural identification of cells displaying either nuclear or cytoplasmic abnormalities was possible in all 8 patients and varied from easily identifiable cell types, like the plasma cell, lymphocyte or histiocyte to those possessing more than one characteristic feature. The immunological staining techniques did not help in the identification of these abnormal cells. We conclude that careful E.M. examination of the mucosal cellular infiltrate in patients with chronic malabsorption can make a valuable contribution in identifying diffusely abnormal cells, though it may not be possible to determine whether they are of histiocytic or lymphocytic origin.
 ...
PMID:The recognition of premalignant change in jejunal mucosal biopsies of patients with malabsorption. 733 46


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>