Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0024523 (malabsorption)
 7,319 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A case of the Zollinger-Ellison syndrome, presented with watery diarrhoea, malabsorption and multiple duodenal ulcers. Resection of a gastrinoma from the head of the pancreas was ineffective. Cimetidine, administered for more than 30 months produced an immediate and sustained relief of symptoms with a gain in weight of 19 kg and improvement of the biochemical features of malabsorption. Gastric acid secretion has been markedly inhibited and duodenal ulceration healed.
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PMID:A review of the Zollinger-Ellison syndrome--with particular reference to a patient treated with cimetidine. 53 59

In this study, we investigated the relationship between gastric emptying and duodenal events in patients with the Zollinger-Ellison syndrome due to a gastrinoma. Like the inhibitory effect of a meal on gastric secretion (described in a companion paper), postprandial inhibition of gastric emptying reduces fractional gastric emptying rates to normal during the first two hours after a meal. Gastric discharges of content into the duodenum fluctuate considerably, and, in some patients, duodenal acid load and neutralising duodenal secretions appear to be incoordinated. These mechanisms interact in part as a protective system that maintains reasonably normal duodenal homeostasis in most Zollinger-Ellison patients during the early postprandial period. Our data may explain why clinical evidence of overt-malabsorption is less prevalent and severe in these patients than would be expected from their enormously increased fasting gastric secretory outputs.
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PMID:Pathophysiological responses to meals in the Zollinger-Ellison syndrome: 2. Gastric emptying and its effect on duodenal function. 738 Mar 44