Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0024523 (malabsorption)
 7,319 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Biological and histological studies were performed in 42 cases of gastro-intestinal intolerance to cow's milk proteins. Hypoproteinemia was present in 2/3 of the cases, anemia in 3/4. Malabsorption syndrome (steatorrhea, xylose) was overt in less than 1 patient out of 2. Serum level of vitamin A was more frequently depressed than that of vitamin E and folinic acid. Intestinal biopsy, performed in 32 children, showed consistent abnormalities, a partial atrophy of the villi being most often seen (26 cases). Eosinophilia was present in 50% of the cases. A titer of anti-milk agglutinins of 1/64 or above was always found if the test was performed repeatedly when the diet of the children contained milk. Lymphocyte proliferation in culture, induced by milk proteins, was positive in 70% of the cases. None the less, no biological or histological findings were found to be specific for gastro-intestinal intolerance to milk proteins.
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PMID:[Digestive intolerance to cow's milk proteins in infants. Biological and histological study]. 124 Jul 51

We describe noninfectious bloody diarrhea in 13 of 16 infants referred for management of short bowel syndrome and parenteral nutrition during a 33-month period. The condition was characterized by bloody, watery stools associated with carbohydrate malabsorption. Colitis occurred at a mean age of 4.2 months during periods of advancing enteral feedings of a hydrolyzed protein- or amino acid-containing formula. Sigmoidoscopy performed in nine patients revealed edema, patchy erythema, loss of normal vascular pattern, and mucosal friability without ulcerations or pseudomembranes. Colonic biopsy specimens demonstrated edema and mixed hypercellularity of the lamina propria, with prominent eosinophilia. Rectal bleeding ceased if formula feedings were decreased or withheld. Of multiple medications administered, sulfasalazine seemed to improve rectal bleeding most effectively in our patients and allowed for more rapid reintroduction of enteral feedings.
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PMID:Noninfectious colitis associated with short gut syndrome in infants. 167 30

Eosinophilic Gastroenteritis (EG) is a poorly understood disorder defined by eosinophilic infiltration of the bowel wall, eosinophilia and gastrointestinal symptoms. The disease's aetiology, course and treatment are not well known. We report two atypical cases of EG: one involving the mucosal layer and another involving the serosal and muscularis layer. The first shows how EG may present with a long history of episodes of intestinal obstruction and malabsorption and how the disease could take a severe course and may be unresponsive to treatment. The second case shows EG presenting as acute abdomen and which subsequently became asymptomatic without therapy, regardless of the fact that peripheral eosinophilia remained present. This case raises the problem of how to treat an asymptomatic patient, what parameters should be considered in order to assess the progress of the disease and the indications for treatment.
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PMID:Eosinophilic gastroenteritis: report of two atypical cases. 174 9

Malignant lymphomas (ML) are malignant proliferations of lymph cells which have become blocked at a certain stage in their feto-embryonic development and, above all, that of their immune response. In order to understand the various forms of primary LM of the gastrointestinal tract, it is necessary to be aware of the various types of B and T cells present in the mucosae associated lymphoid tissue (MALT). After a morphologic and immunophenotypic description of the constituting elements of MALT, the different types of gastrointestinal M and T ML are reviewed. The features which distinguish them from ML of the lymph nodes and spleen are indicated. Three main types should be highlighted. Firstly, the centrocytic ML and/or MALT-type lymphoplasmocytic ML, which has low malignancy and are the most common. The cases previously described as "pseudo-lymphomas" are in fact true ML belonging to this group. Secondly, the B ML, which are highly malignant may or may not be preceded by or associated with a low-malignancy ML of the MALT-type. Thirdly, T ML, which are always unusual and highly malignant and which correspond to the malignant proliferation of intra-epithelial T lymphocytes. A malabsorption syndrome may precede or accompany this form, which may in other cases be accompanied by marked eosinophilia. The place of MALT-type ML in the Kiel classification is discussed.
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PMID:[Normal lymphoid tissue and primary malignant lymphomas of the gastrointestinal tract]. 202 83

In 3 years, Dicrocoelium dendriticum ova were detected in 208 patients at the Armed Forces Hospital, Riyadh, Saudi Arabia during 1984-1986. At least 7 of these patients had a true infection and at least 34 patients had spurious infection as they gave a history of eating raw liver. 23% of the 208 patients were under 14 years of age. The peak incidence was between October and November in each of the 3 years. 134 of these patients were symptomatic. 16 patients had disturbed liver functions and 13 had eosinophilia. 10 patients had gall bladder or biliary tree disease and in at least 2 of which it was due to D. dendriticum. Malabsorption occurred in one patient. Praziquantel was used in 9 patients and was successful in treating 4 of these patients.
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PMID:Human dicrocoeliasis. Report on 208 cases from Saudi Arabia. 226 Jan 88

A 20-year-old woman is presented who had eosinophilic gastroenteritis of the muscularis and serosal type which involved the terminal ileum. The diagnosis was initially acute appendicitis, but clues to the correct diagnosis included the presence of malabsorption, protein-losing enteropathy, abdominal pain and ascites, and especially a history of recurrent bouts. Peripheral eosinophilia is found in most cases and biopsy, or a peritoneal tap when ascites is present, may demonstrate a predominantly eosinophilic infiltration. Radiographic findings include a rigid, open ileocecal valve. There is rapid response to corticosteroid therapy, but long term follow-up is required because the disease may run a chronic, relapsing course.
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PMID:[Eosinophilic gastroenteritis]. 280 53

Collagenous colitis is a clinicopathologic syndrome with chronic watery diarrhea, diffuse colitis with surface epithelial injury, and a distinctive collagen band beneath the surface epithelium especially in the proximal colon. The cases of seven patients (including six middle-aged women) with chronic, watery, noninfectious diarrhea were studied. Roentgenographic and endoscopic findings were not diagnostic. Two patients had rectal mucosal inflammation but sparing of the distal colon from subepithelial collagen. Other findings included thyroid disease (four patients), urethral fibrosis (three), elevated erythrocyte sedimentation rate (six), and eosinophilia (three). The colon was thought to be the main source of diarrheal fluid, but bile salt malabsorption, steatorrhea, and net small-bowel secretion were additive factors in some patients. With antiinflammatory treatment the diarrhea abated, the surface epithelial injury decreased, and the subepithelial collagen resolved (two patients), but lamina propria inflammation persisted. Collagenous colitis seems to be a chronic systemic, and perhaps autoimmune, disorder.
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PMID:Collagenous colitis: physiologic and histopathologic studies in seven patients. 378 77

Eosinophilic gastroenteritis is an uncommon disorder of unknown etiology characterized by recurrent episodes of infiltration of the gastrointestinal wall with eosinophils and peripheral eosinophilia. The Authors report a patient in which ascites with eosinophilia in the ascitic fluid was the cardinal feature of the disease. A low E.S.R. in the acute phase of illness was found. Steroids are indicated in patients presenting obstructive symptoms or malabsorption. In our case the treatment was not necessary because of the spontaneous remission of the symptoms.
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PMID:[Eosinophilic gastroenteritis simulating ascites (eosinophilic ascites). Presentation of a case and review of the literature]. 408 27

A patient with febrile ulceronecrotic Mucha-Habermann's disease manifested the characteristic features of this entity. These include a polymorphous eruption with histopathologic findings of Mucha-Habermann's disease, large ulceronecrotic skin lesions, intermittent high fever, and constitutional symptoms. The patient was unique in that he also had malabsorption and eosinophilia. This disease may represent a hypersensitivity reaction. To our knowledge, there are five previous cases of febrile ulceronecrotic Mucha-Habermann's disease reported in the world literature.
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PMID:Febrile ulceronecrotic Mucha-Habermann's disease. 685 3

A case with severe diarrhoea and Strongyloides stercoralis infection is described. Further examination showed that the patient also had abnormal colonization of the duodenum with Hafnia alvei and that this disappeared when the Strongyloides infection was treated with mebendazole. Symptoms such as abdominal pain, diarrhoea, "skin rash" and malabsorption in association with blood eosinophilia should arouse suspicion of strongyloidiasis.
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PMID:A case with severe diarrhoea and Strongyloides stercoralis infection. 723 12


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