Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0024312 (lymphopenia)
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Human Gene/Protein
FCH domain only 1 12.7
immune associated nucleotide 12.1
IAN5 11.7
GIMAP5 11.3
NLRP1 protein 11.1
tetratricopeptide repeat domain 7A 10.7
HMOX1 protein 9.9
FOLR4 9.9
JAGN1 9.7
RABEP1 9.7
GIMAP1 9.5
MAGT1 9.5
HLA-B*5401 9.4
MHC class 1 antigen 9.2
GIMAP4 9.2
SPNS2 9.0
PLA2G10 9.0
dedicator of cytokinesis 2 8.9
ALC2 8.9
IL2RG 8.8
RT6 8.8
S1PR5 8.7
adenylate kinase 2 8.7
complement component 9 8.7
Transcriptional regulator 8.7
PIK3CD 8.7
LyP 8.7
TRNT1 8.6
sphingosine-1-phosphate lyase 8.6
transcription factor II H 8.6
MYSM1 8.5
dedicator of cytokinesis 8 8.5
Ras-related C3 botulinum toxin substrate 2 8.4
TSPYL1 8.4
HM5 8.4
DEFA4 8.4
ARPC1B 8.4
interaction 1 8.4
IGHG4 8.4
CD22 antigen 8.4
SPHK2 8.3
sPLA2-X 8.3
MRX34 8.3
STK4 8.3
AGM1 8.3
CD95 antigen 8.2
phosphoacetylglucosamine mutase 8.2
NHEJ1 8.2
WASP interacting protein 8.2
Leu-16 8.0
SGPL1 8.0
FBXL4 8.0
ILT7 8.0
CD8B 8.0
XLF 7.9
ATP11A 7.9
CD3Z 7.9
SPHK 7.9
C1QB 7.9
CD52 7.9
sphingosine kinase 2 7.8
sphingosine-1-phosphate receptor 1 7.8
MAGE3 7.8
DOCK8 7.8
transmembrane protein 3 7.7
NKAP 7.7
DCLRE1C 7.7
GAS7 7.7
trypsin 1 7.7
S1P1 7.7
SLC20A1 7.6
S1P 7.6
S1P5 7.6
TOSO 7.6
CD3G 7.6
dCK 7.6
CVID 7.5
EVER2 7.5
ATMIN 7.5
severe combined immunodeficiency 7.5
more...
Disease
lymphopenia 12.7
Chancriform syndrome 12.7
Trichophytic granuloma 12.7
viral leukoencephalopathy 12.7
Mature B cell neoplasms 12.7
Bronchiectasis, recurrent 11.7
Renal azotemia 11.7
eosinopenia 11.2
Neonatal isoerythrolysis 11.1
Adenylate kinase deficiency 11.1
Primary intestinal lymphangiectasia 11.1
Warts, hypogammaglobulinemia, infections, and myelokathexis 10.9
Mycoplasma arthritis 10.7
Granulocytosis 10.5
Panhypogammaglobulinemia 10.4
Myeloid hyperplasia 10.1
Myelokathexis 9.9
Lymphocytic-plasmacytic enteritis 9.9
Valvular endocarditis 9.7
Lupus myocarditis 9.7
Combined immunodeficiency 9.6
stage II Hodgkin's disease 9.5
Coombs positive hemolytic anemia 9.4
Persistent lymphocytosis 9.4
adult solid tumor 9.4
FAIDS 9.3
Good's syndrome 9.3
Feline panleukopenia 9.2
Hepatozoonosis 9.1
PNP deficiency 9.0
Nezelof 9.0
Lymphocytic alveolitis 9.0
Equine viral arteritis 9.0
Uterine atrophy 9.0
reticular dysgenesis 8.9
MRX34 8.9
Burkholderia cepacia infection 8.9
ADA deficiency 8.7
methionine synthase deficiency 8.7
Secondary immunodeficiency 8.7
Acute esophagitis 8.7
Norwalk gastroenteritis 8.6
Vacuolar myelopathy 8.6
Queensland tick typhus 8.5
Myeloid metaplasia 8.5
Systemic fungal infection 8.4
Cytokine storm 8.4
hypogammaglobulinemia 8.3
bacterial colitis 8.2
Mulvihill-Smith syndrome 8.2
EBV viremia 8.1
Omenn's syndrome 8.1
Mixed gonadal dysgenesis 8.0
angiocentric T-cell lymphoma 8.0
angiocentric T-cell lymphoma 8.0
Cervical lymphadenitis 8.0
Anaplasmosis 7.9
leukopenia 7.9
Primary immunodeficiency 7.9
T-cell deficiency 7.8
thymitis 7.8
ADA-SCID 7.8
Amyopathic dermatomyositis 7.8
Chronic endometritis 7.8
hyperproteinemia 7.7
hypoglobulinemia 7.7
Reactive hemophagocytic syndrome 7.7
phagocytic dysfunction 7.7
Pneumocystis jiroveci pneumonia 7.6
Distemper 7.6
Systemic inflammatory response syndrome (SIRS) 7.6
hematological abnormality 7.6
Klebsiella sepsis 7.5
Lassa virus infection 7.5
Penicilliosis 7.5
Neisseria infections 7.5
Malignant pheochromocytoma 7.5
lymphocytosis 7.5
congenital immunodeficiency 7.4
Hodgkin's-like 7.4
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Symptom
Cutaneous anergy 9.4
cracked lips 8.5
hypoproteinemia 7.5
Koplik spots 7.4
Reticulocytosis 7.1
Flu-like symptoms 6.9
Severe diarrhea 6.9
staggering gait 6.5
meningism 5.9
inanition 5.9
generalized erythema 5.8
decreased appetite 5.7
asthenia 5.6
lethargy 5.6
non-productive cough 5.5
nasal discharge 5.4
myalgia 5.4
physical exhaustion 5.3
rigors 5.3
leg edema 5.3
chills 5.3
anorexia 5.2
prostration 5.1
hepatosplenomegaly 5.1
splenomegaly 5.1
emaciation 5.0
polydipsia 4.9
loss of balance 4.9
disturbed balance 4.8
night sweats 4.8
cough 4.7
periorbital edema 4.7
tachypnea 4.7
polyuria 4.7
chest tightness 4.7
abdominal cramps 4.6
swollen joints 4.6
arthralgia 4.6
lassitude 4.5
adenitis 4.5
diarrhea 4.5
fever of unknown origin 4.5
persistent cough 4.4
shortness of breath 4.4
cachexia 4.4
photophobia 4.4
vomiting 4.3
respiratory distress 4.3
nausea 4.3
sore throat 4.2
pallor 4.2
dyspnea 4.2
productive cough 4.1
hepatomegaly 4.1
colic 4.0
Ill 4.0
fatigue 4.0
erythema 3.9
Respiratory symptoms 3.8
dry skin 3.7
chronic cough 3.7
cerebellar ataxia 3.7
hyperesthesia 3.6
excessive sweating 3.5
Gastrointestinal symptoms 3.5
pleuritic chest pain 3.5
incoordination 3.5
neck stiffness 3.4
rales 3.4
exhaustion 3.3
acute stress 3.3
limb pain 3.3
apathy 3.3
dizziness 3.1
rhinorrhea 3.1
anosmia 3.1
nausea and vomiting 3.0
intestinal bleeding 3.0
constipation 2.9
livedo 2.9
more...
Drug
Siplizumab 10.1
Tnt 10.1
Visilizumab 9.9
Hemocoagulase 9.2
Saperconazole 8.9
Caramel 8.8
Campath 8.5
Campath 8.5
Forodesine 8.2
Sivelestat sodium hydrate 8.1
Potassium carbonate 8.1
Maduramicin 7.9
Pralatrexate 7.7
Feldene 7.5
Acemannan 7.5
Antithymocyte globulin 7.3
Vatalanib 7.2
Fludarabine 7.0
Cidofovir 6.9
Romidepsin 6.8
Ontak 6.8
Ontak 6.8
Deoxyadenosine 6.7
Adenosine deaminase 6.7
Midostaurin 6.7
Gamma globulin 6.6
Tipifarnib 6.5
Velban 6.5
Trimethoprim-sulfamethoxazole 6.4
Gallium nitrate 6.4
Lenalidomide 6.3
Ixabepilone 6.3
Thymopentin 6.3
Pirarubicin 6.2
Zinc sulfate 6.1
Betaseron 6.1
Zinc sulfate 6.1
Belimumab 6.1
Tocilizumab 5.9
Icodextrin 5.9
Efalizumab 5.8
Efalizumab 5.8
Maalox 5.7
Intron A 5.6
Imiquimod 5.6
Intron A 5.6
Vandetanib 5.6
Avonex 5.5
-deoxyadenosine 5.5
Darunavir 5.5
Interferon beta 5.4
Oseltamivir 5.4
Xeloda 5.4
Copaxone 5.4
Dilantin 5.4
Beta-2 5.3
Prednisone 5.3
Bexarotene 5.2
Prograf 5.2
L-Asparaginase 5.2
Vorinostat 5.2
Daclizumab 5.1
Natalizumab 5.1
Bactrim 5.0
BLyS 5.0
Thiopentone 5.0
Aztec 4.9
Rituximab 4.9
Everolimus 4.8
Bortezomib 4.7
Voltaren 4.7
Cellulose acetate 4.6
Tuberculin 4.5
Serum albumin 4.4
Auranofin 4.3
IL-2 4.3
Codeine 4.3
Mycophenolic acid 4.3
Ketoconazole 4.2
Codeine 4.2
more...
Enzyme
D-2-hydroxy acid dehydrogenase 9.7
STK4 8.3
adenine deaminase 7.0
serum carnosinase 6.8
sphingosine kinase 5.9
rhomboid protease 5.9
purine nucleoside phosphorylase 5.7
angiotensin-converting enzyme 2 5.5
adenosine deaminase 5.4
adenosine deaminase 5.4
MTD 5.0
pyridoxal kinase 4.9
lysophospholipase D 4.9
methylthioadenosine phosphorylase 4.8
deoxycytidine kinase 4.8
S-adenosyl-L-homocysteine hydrolase 4.6
nucleoside hydrolase 4.6
Thy1 4.4
orotidine-5'-phosphate decarboxylase 4.3
orotate phosphoribosyltransferase 4.3
propionyl-CoA carboxylase 4.3
proteinase-3 4.3
Omi/HtrA2 4.3
propionyl-CoA carboxylase 4.3
sorbitol dehydrogenase 4.2
lactic acid dehydrogenase 4.1
caspase-2 4.1
BAL 4.1
AST 4.0
caspase-2 4.0
aspartate aminotransferase 4.0
galactocerebrosidase 4.0
NAD glycohydrolase 3.9
lactate dehydrogenase 3.9
indoleamine 2,3-dioxygenase 3.8
farnesyltransferase 3.7
CYP27A1 3.6
dihydropteroate synthase 3.6
PAL 3.6
aldehyde dehydrogenase 3.6
MIP 3.6
creatine kinase 3.5
CCS 3.5
HDR 3.4
alanine aminotransferase 3.4
BMT 3.3
type III procollagen 3.2
thromboplastin 3.2
ribonucleotide reductase 3.2
ribonucleotide reductase 3.1
farnesyltransferase 3.1
galactose oxidase 3.0
methionine synthase 3.0
DTA 3.0
phosphoglucose isomerase 2.9
p100 2.9
methionine synthase 2.8
DNA ligase 2.8
DNA ligase 2.8
BIS 2.8
diacylglycerol kinase 2.7
ADP-ribosyltransferase 2.7
nucleotidase 2.7
thymidine phosphorylase 2.7
lysin 2.7
ADP-ribosyltransferase 2.6
5'-nucleotidase 2.6
granzyme B 2.6
GRK5 2.5
alkaline phosphatase 2.5
PCP 2.4
PCE 2.3
SPC 2.3
asparaginase 2.3
phosphoglucomutase 2.3
neutrophil elastase 2.3
CD10 2.2
neuraminidase 2.2
TPP 2.2
phosphoinositide 3-kinase 2.2
more...
Compound
Diapamide 11.7
Pyrazine diazohydroxide 9.9
Fludarabine phosphate 9.3
Pyrazine diazohydroxide 9.2
BSSG 9.0
3-methoxy-17-methylmorphinan 8.9
2-(2-methoxyethoxy)ethanol 7.9
3-Aminopyridine 7.8
Dimethyl fumarate 7.5
Ditan 7.5
Deoxycoformycin 7.5
2-amino-1,3-propanediol 7.4
Boldenone 7.3
Sphingosine 1-phosphate 7.3
Cidofovir 7.0
S-15 7.0
Temozolomide 6.9
Purine nucleoside 6.8
Cortisone acetate 6.8
Deoxyadenosine 6.8
Velban 6.7
ara-AMP 6.7
ara-AMP 6.7
CD 3 6.6
Temsirolimus 6.3
BPQ 6.3
3-aminobenzoic acid 6.3
DCH 6.2
Sphingosine 6.1
Hydrocortisone acetate 6.0
Zinc sulfate 6.0
Oseltamivir 6.0
Tiazofurin 6.0
Tanakan 6.0
Beclomethasone dipropionate 6.0
TNA 5.9
Berenil 5.9
Diethylcarbamazine 5.8
Hydroxychloroquine 5.8
Quinapril 5.6
A 150 5.6
GML 5.5
cyclohexanecarboxylic acid 5.5
cyclohexanecarboxylic acid 5.5
cyclohexanecarboxylic acid 5.5
cyclohexanecarboxylic acid 5.5
cyclohexanecarboxylic acid 5.5
MeCCNU 5.5
Droperidol 5.5
Meclofenamate 5.4
1-aminocyclopropanecarboxylic acid 5.3
DQ1 5.3
1,3-propanediol 5.2
PPD 5.2
Interleukin-2 5.2
Elan 5.2
Nelfinavir 5.1
PPD 5.1
Prone 5.1
Levamisole 5.1
6-Mercaptopurine 5.0
Keloid 5.0
IAN 5.0
Tauroursodeoxycholic acid 5.0
Fumarate 4.9
Poly(I:C) 4.9
Elan 4.9
Plumbagin 4.9
BTO 4.8
Cortisone 4.8
Triamcinolone 4.8
G 1 4.7
Acridine Orange 4.7
Acridine Orange 4.7
Acridine Orange 4.7
NKT 4.7
Leukotriene B4 4.7
neopterin 4.7
CPH 4.7
Capecitabine 4.7
more...