Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0024312 (lymphopenia)
 4,859 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Coventional kittens, 12-27 weeks old, were inoculated with cell-cultured feline panleucopenia virus and killed sequentially between day 3 and day 24 after inoculation. All developed a non-fatal mild disease between days 2 and 9, characterized by lymphopenia, neutropenia, listlessness, depression and the development of neutralizing antibodies to the virus. Small intestinal bacterial counts were reduced during the period of maximal clinical disease, presumably a result of decreased food intake. There was involution of the thymus with marked depletion of lymphocytes between days 3 and 12. Depletion of lymphocytes also characterized the lesions in the lymph nodes between days 3 and 8. At the same time crypt lesions with spotty distribution were in the small intestinal and colonic mucosa. The changes were loss of crypt epithelial cells with compensatory attenuation of the remaining epithelium. Electron microscopically, the number and size of microvilli and secretory granules were reduced but there was no change indicating lethal cell injury. There were no virus particles. The findings point to an early and transient cellular damage by the virus. Intestinal alkaline phosphatase activity disappeared from the luminal surface of the attenuated crypt epithelial cells. Otherwise, intestinal alkaline and acid phosphatase activity were not altered in inoculated cats.
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PMID:Experimental feline panleucopenia in the conventional cat. 93 27

Experiments carried out on mature rabbits have shown that 12-hours-long immobilization induced in the peripheral blood of animals neutrophilic leukocytosis accompanied by a decrease in the amount of lysosomas and granules of lysosomal cationic proteins in neutrophilocytes. In compliance with this the activity of acid phosphatase (AP), a marker lysosomal enzyme of granulocytes, in the blood serum has grown. Under these conditions we observed guantitative changes in humoral (an increase in the amount of circulating immune complexes (CIC) in the lymph as well as in B-cells) and in cellular (general T-lymphopenia, a sharp increase in the number of T-theophylline-sensitive and T-theophylline-resistant lymphocytes) components of the immunity at the initial period of the stress-syndrome formation. It is supposed that there is a definite relation between immunoreactivity of the organism and activity of lysosomal enzymes of neutrophilic granulocytes in the peripheral blood under conditions of immobilization stress.
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PMID:[Reaction of the lysosomal apparatus of neutrophilic leukocytes in the peripheral blood and immunoreactivity of the organism during immobilization]. 775 8

To evaluate a possible mechanism of stress-induced lymphopenic effect we assessed the activity of lymphocyte lysosomal enzymes (LE) under immobilization. The effects of immobilization stress on LE (AP, acid phosphatase, cathepsin D and L, beta-N-acetyl-glucosamidase) activity in lymphocytes, number of lymphocytes and plasma cortisol (COR) level in the peripheral blood were examined in the cross-bred Pietrain pigs showing genotypic (presence or lack of RyR1 gene mutation) and phenotypic (reactivity to halothane) differences. It was found that immobilization stress evoked an increase in LE which was concomitant with lymphopenia and a rise of COR level. The most pronounced enhancement of LE, which may reflect a tendency to lymphocyte cytolysis, was found in the recessive homozygotes RyR1 (nn) phenotypically defined as stress/halothane susceptible as well as in the heterozygotes RyR1 (Nn) included in the group of stress/halothane resistant. Despite this individual variability the stress-induced increase in LE activity was present in all the animals. It seems that a possibility of destruction (lysis) of lymphocyte cells should not be excluded as one of the causes of stress lymphopenia.
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PMID:Stress-induced enhancement of activity of lymphocyte lysosomal enzymes in pigs of different stress-susceptibility. 1724 73