Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0024312 (lymphopenia)
 4,859 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The cellular and humoral immunity of patients with pulmonary tuberculosis has been evaluated prospectively in 22 PPD-positive and 10 PPD-negative patients by intradermoreaction (IDR), blast transformation (SL) and MIF production in response to PPD, Candida and varidase, peripheral lymphocyte count, and quantitative evaluation of immunoglobulins. There is a very good correlation between the different tests, and anergy is frequently found in elderly patients. Negative results (IDR, SL, MIF) are significantly observed in the presence of a negative PPD-IDR, lymphopenia (less than 1,000/mm3), impaired blast transformation in response to PHA (less than 21,000 cpm), and a cavitary form of tuberculosis. These findings suggest a defect of cellular immunity in these patients.
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PMID:[The immunologic status during pulmonry tubercuolsis]. 100 54

A 25-day-old Chinese female baby developed necrotizing fasciitis (NF) with indurated erythematous patches with superficial necrosis over two thirds of the back. Skin cultures of the lesions yielded Streptococcus pyogenes, enterococcus, Pseudomonas aeruginosa, and Candida species. The patient had lymphopenia with low T cells and T cell subsets. The lymphoproliferative response to mitogen and macrophage migration (MIF) production were also poor. Her lymphocytes were unable to produce IgG in vitro. Also, IgG bearing cells were not demonstrable. The initial lymph node biopsy demonstrated an absence of follicular formation and depletion of lymphocytes in both thymic-dependent and thymic-independent areas. Five weeks after bovine thymic extract (Thymostimulin) treatment, a second lymph node biopsy demonstrated germinal centers containing IgG bearing cells. Three weeks later, a third lymph node biopsy showed germinal centers with cuffs of lymphocytes. Differentiation of the cortex and medulla of the node was demonstrated. IgG was also detectable in an in vitro Ig synthesis study. The total T cells, T cell subsets, lymphoproliferative response MIF production also increased gradually after Thymostimulin treatment. This investigation demonstrated the therapeutic effectiveness of Thymostimulin in NF with underlying combined immuno-deficiency, both serious and frequently fetal diseases, by the histologic and immunologic reconstitution of T and B cell function.
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PMID:Serial immunologic and histopathologic studies in the treatment of necrotizing fasciitis with combined immunodeficiency by a bovine thymic extract (thymostimulin). 379 38