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Query: UMLS:C0024312 (lymphopenia)
 4,859 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Seven, adult, female beagles were inoculated with a Swedish granulocytic Ehrlichia organism closely related to Ehrlichia equi and E. phagocytophila. Blood and bone marrow changes were evaluated throughout the acute phase of infection. All dogs developed moderate to severe thrombocytopenia during the parasitemic period. The mean platelet volume and platelet distribution width increased, and large platelets were seen on blood smears when platelet numbers were low. In bone marrow, absolute numbers of megakaryocytes and immature megakaryocytes were increased. These results suggested the thrombocytopenia was caused by increased platelet destruction. The dogs also developed mild, normocytic, normochromic anemia, with simultaneous decreases in serum iron concentration and total iron-binding capacity that resembled the anemia of inflammation. In bone marrow, there was a slight increase in immature erythroid cells and no erythroid hypoplasia; iron stores were normal to increased. Myeloid hyperplasia was seen in all infected dogs, despite neutropenia in peripheral blood. Lymphopenia occurred early in the parasitemic period, but lymphocytes responded strongly and numbers increased above baseline levels by the end of parasitemia. Blast-transformed lymphocytes (5% to 20%) were seen in peripheral blood for a few days. Experimentally-induced canine granulocytic ehrlichiosis caused cytopenias of short duration, coincident with the appearance of ehrlichial inclusions in neutrophils.
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PMID:Hematopathology in dogs experimentally infected with a Swedish granulocytic Ehrlichia species. 1207 39

Canine granulocytic anaplasmosis is a disease diagnosed in many areas of the United States, with the highest prevalence reported in dogs in the upper midwestern, northeastern, and western states. It is also found in several European countries. Anaplasmosis can manifest with a wide range of clinicopathologic findings. A 20 wk old puppy was presented with physical examination and laboratory findings atypical of the disease. In addition to other signs, abdominal effusion was detected. Diagnostic evaluation confirmed that the puppy was positive for anaplasmosis. No morulae were found in peripheral white blood cells, but morulae were apparent in the white cells of the abdominal effusion. Leukopenia was observed, characterized by neutropenia, as opposed to the lymphopenia and eosinopenia typically seen with the disease. Blast cells were also seen in the peripheral blood, and reactive lymphocytes were noted in the bone marrow. The patient responded well to doxycycline therapy. All hematologic and physical abnormalities resolved.
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PMID:An unusual presentation of granulocytic anaplasmosis in a young dog. 2167 37