Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0024312 (lymphopenia)
 4,859 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We have compared risk factors for cavitary histoplasmosis in 62 patients with that manifestation of the infection and in 679 patients with other forms of histoplasmosis, and we have evaluated the clinical and laboratory findings in 45 patients with cavitary histoplasmosis who were cared for at the Indiana University Medical Center hospitals during two large histoplasmosis outbreaks. Chronic obstructive lung disease and old age were the strongest risk factors for cavitary histoplasmosis but male sex, white race and immunosuppression were also important in certain patient groups. Fever, sweats, weight loss, productive cough, anemia, lymphopenia, and alkaline phosphatase elevation were common findings. The patients were occasionally incorrectly treated for presumed class 3 tuberculosis. Cultures were positive in 58% of patients, with sputum samples providing the highest yield (61%). Histoplasmal serologic tests provided useful clues to the diagnosis, positive in over 90% of cases. About one-third of patients recovered spontaneously while another 35% improved following treatment. About 4% developed chronic untreated cavitary histoplasmosis characterized by clinical and roentgenographic exacerbations and remissions. Of the deaths in four patients with untreated disease, one was caused by disseminated histoplasmosis while three died of other causes. Ketoconazole appeared effective in three of seven patients while its effect in three additional patients was uncertain. Toxicity precluded completion of ketoconazole therapy in one patient. Only amphotericin B has been proven to be effective therapy for cavitary histoplasmosis.
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PMID:Cavitary histoplasmosis occurring during two large urban outbreaks. Analysis of clinical, epidemiologic, roentgenographic, and laboratory features. 673 42

This was a cross sectional study to determine the clinical, laboratory and radiologic characteristics of confirmed avian influenza (AI) (H5N1) infection among children and adults. This study was conducted at Sulianti Saroso Infectious Diseases Hospital (SS-IDH), Jakarta among subjects confirmed to have AI infection hospitalized during September 2005 to August 2010. The proportion of confirmed AI patients was 33 out of 321 suspected and probable cases (10.2%). Of 26 subjects analyzed (7 subjects was excluded due to loss of or incomplete medical records), the median ages were 7 years and 25 years in children and adults, respectively (range 1 - 39 years). Prominent clinical features were respiratory symptoms [productive cough (13/13 children; 12/13 adults), dyspnea (12/13 children; 13/13 adults)], and fever (12/13 children; 12/13 adults). Leukopenia was found in 9 subjects in each group. Four children and 7 adults had lymphopenia, while thrombocytopenia was found in 7 children and 10 adults. Two children had an increased ALT, while most adults had an increased AST (10/13) and/or ALT (8/13). Bilateral infiltrates found in most subjects on chest x-ray who had clinical deterioration. Of the 3 children who survived out of 13 children with AI, they all had less severe clinical features and no central nervous system involvement, lymphopenia, thrombocytopenia, or increased creatinine level. None of the adults survived.
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PMID:Clinical, laboratory, and radiologic characteristics of confirmed avian influenza (H5N1). 2307 10

We retrospectively reviewed the medical records of 17 fatal H7N9 cases in Shanghai in 2013, analyzed clinical variables and described their clinical and epidemiologic characteristics. The median age was 73 years, and 82.4% had underlying medical conditions. The most frequent symptoms were fever (100%), followed by productive cough (47.1%) and dry cough (35.5%). Thirteen (76.5%) patients had dyspnea or respiratory distress, five (29.4%) had shock, and four (23.5%) had acute kidney injury. Seventeen (100.0%) patients had lymphopenia. Involvement of both lungs was found by chest radiography in 14 (82.4%) patients at presentation. Fifteen (88.2%) patients were hospitalized. The median times from illness onset to hospitalization and to diagnosis confirmation were both six days. Eleven (64.7%) patients were admitted to the intensive care unit. Sixteen (94.1%) patients were treated with oseltamivir. The median time from illness onset to oseltamivir treatment was six days. Among six patients for whom the duration of viral shedding was available, the median duration of viral shedding after oseltamivir treatment was 17 days. The median time from illness onset to death was 11 days. Refractory hypoxemia accounted for most deaths. The clinical and epidemiologic characteristics in the Shanghai fatal series of patients do not differ from other reports of H7N9 patients in China. This investigation reflects a delay in the diagnosis and antiviral treatment of H7N9 patients in the early stage of the epidemic in Shanghai. Late antiviral treatment and a long duration of viral shedding may be associated with a fatal outcome in these patients.
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PMID:Fatal cases of human infection with avian influenza A (H7N9) virus in Shanghai, China in 2013. 2578 12