Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0024312 (lymphopenia)
 4,859 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

One hundred thirty two patients with disseminated malignant melanoma were treated using a combination of BCNU, vincristine and imidazole carboxamide. A response rate of 23% was observed, while 16% had stable disease. The patients' median survival was 42 months from diagnosis and 5.3 months from the onset of treatment. These results are not significantly different from therapy with imidazole carboxamide alone. Patients on this study were observed to have a significant reduction in the number of lymphocytes in their peripheral blood (mean 1800/mm3, median 1550/mm3). Patients with lymphopenia prior to the onset of therapy (86%) had a similar response rate but a shorter median survival (4.4 months vs. 7.8 months, P = .03) than patients with normal lymphocyte levels. These findings are compatible with recent observations on the importance of host immunocompetence in patients with malignant melanoma. Eosinophil levels were not closely correlated with response, although among patients with eosinophil counts of greater than 300/mm3 (22%), a slightly higher response rate (29%) was observed (P = .13). Eosinophilia did not influence patient survival.
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PMID:Combination chemotherapy with bis chloroethyl nitrosourea (BCNU), vincristine and dimethyl triazeno imidazole carboxamide (DTIC) in disseminated malignant melanoma. 83 24

In a 4-month double-blind study the effects of dimethylfumaric acid esters (DMFAE-EC) and DMFAE plus salts of monoethylfumaric acid esters (fumaric acid combination, FAC-EC) in enteric-coated tablets were compared in 22 respectively 23 patients with psoriasis. In both groups about 50% showed a considerable improvement, i.e. the initial score was more than halved. The therapeutic effects showed no significant differences in both groups with respect to the total psoriasis score or the different parameters. In the FAC-EC group the effects were obtained more rapidly. Most frequently observed side effects in both groups were flushings, stomachache and diarrhea. Due to these complaints 3 respectively 8 patients discontinued therapy. Eosinophilia, leukopenia and lymphopenia were the most frequently observed differences in lab tests. It was concluded that FAC-EC had no significantly better effect than monotherapy with DMFAE-EC. Moreover, enteric coating of the tablets did not prevent stomach complaints. Until more information has been obtained about the pharmacokinetics, the toxicity and optimal composition of the drug, the fumaric acid therapy in psoriasis should be seen as experimental.
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PMID:Fumaric acid therapy in psoriasis: a double-blind comparison between fumaric acid compound therapy and monotherapy with dimethylfumaric acid ester. 239 1

The absolute count for a particular type of blood cell is the total white blood cell count multiplied by the differential percentage for that cell type. Neutrophilia is caused by increased marrow proliferation, redistribution among body neutrophil pools, stress and corticosteroids. Neutropenia is caused by decreased marrow proliferation, ineffective marrow production, reduced neutrophil survival and redistribution of neutrophils. Lymphocytosis is caused by chronic infections and allergic reactions, while lymphopenia is caused by increased lymphocyte destruction, neoplasia and lymphocyte loss. Monocytosis is associated with stress, infections, hematologic disorders, GI disease, necrosis and hemolysis. Eosinophilia is caused by allergic reactions, parasitism, skin diseases, neoplasia and adrenocortical insufficiency.
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PMID:Interpreting absolute WBC counts. 673 20

Case records of 26 patients with Lyell Syndrome were reviewed for studying haematologic abnormalities. Eosinophilia, neutropenia, thrombopenia were uncommon. Circulating immature granulocytic cells were frequently encountered during the second week of evolution, mostly when leucocytosis was present. Anemia was frequent, the lowest haemoglobin titer beeing reached by the 15th day. Reticulocytosis was initially low and reached a peak during the second week. At that time biological markers of inflammatory syndrome were getting worse. So the originating anemia seems primarily of medullary origin and independent of inflammatory syndrome. Lymphopenia was constant and sometimes marked, with no circulating lymphocytes in two cases. The lowest numbers of lymphocytes were observed during the first week. These haematological abnormalities may have some pathogenic significance.
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PMID:[Hematologic anomalies in Lyell's syndrome. Study of 26 cases]. 688 53

Serum chemistry values and complete blood counts were determined for 36 wild dusky-footed wood rats (Neotoma fuscipes) from Sonoma and western Yolo County, California (USA) in summer 1999 and spring 2001. All wood rats had adequate body condition and were hydrated. Many hematologic and biochemical values were comparable to those for house rat (Rattus rattus). There were differences between wood rats tested immediately after capture (those from Yolo County) and after a week of habituation in the laboratory (Sonoma County). Significant differences were noted in red blood cell counts, hemoglobin, hematocrit, neutrophil:lymphocyte ratio, glucose, alanine transaminase, aspartate aminotransferase, and alkaline phosphatase values. The neutrophil:lymphocyte ratio may have been iatrogenically modified in the wood rats tested immediately after capture by stress-induced neutrophilia and lymphopenia. Eosinophilia may have been associated with parasites such as botflies in four individuals, and hyperglycemia in three individuals could have been associated with stress. The cause of elevated enzymes in the animals tested after laboratory habituation is unclear. The hematologic and biochemical values of these apparently healthy wood rats provide valuable baseline information for use in further medical studies performed with this species.
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PMID:Hematology and serum biochemistry values of dusky-footed wood rat (Neotoma fuscipes). 1223 75

DRESS (drug reaction with Eosinophilia and systemic symptoms) is a syndrome classically considered as a severe cutaneous drug adverse reaction. But visceral manifestations (renal, liver, lung, heart...) may be at the forefront. It presents clinically as an exanthema evolving to erythroderma with facial edema, associated with lymphadenopathy, high fever, visceral involvement (hepatitis, renal failure, pneumonitis, or hemophagocytic syndrome), eosinophilia preceded by lymphopenia and/or atypical lymphocytes. DRESS is characterized by a long delay between the first drug intake and its development (2 weeks to 3 months) and by its long course (more than 2 weeks) with flares even after drug discontinuation. Its pathophysiology is unique: it is the consequence of the immune response against Herpesvirus (HHV6, EBV, CMV) reactivation. It is induced by some drugs (allopurinol, anticonvulsants, sulfasalazine, minocycine...). Its early diagnosis is necessary for a rapid discontinuation of the culprit drug. Its management includes a long-term followup, and according to the severity either topical steroids, systemic steroids, intravenous gammaglobulins, or antiviral.
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PMID:[Drug reaction with eosinophilia and systemic symptoms (DRESS)]. 2342 9