Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0024312 (lymphopenia)
 4,859 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

This study presents a retrospective analysis of clinical and laboratory results of 22 patients--predominantly younger women--with thyroiditis de Quervain. Diagnosis is based on clear leading symptoms like swelling and tenderness of the thyroid on pressure, swallowing with pain radiating to mandible and/or ears, fever and increased erythrocyte sedimentation rate (ESR). Half of the patients had slight anemia, leucocytosis without shift to the left, lymphopenia and thrombocytosis. The therapy of choice was prednisone, starting with an initial dose of usually 50 mg, reduced stepwise over 3 months under control of the clinical picture and the sedimentation rate. In a third of the patients clinical symptoms of the disease that had disappeared transiently redeveloped under reduction of prednisone without increase of the erythrocyte sedimentation rate. Raising the dose of prednisone for a short while led to prompt disappearance of symptoms. The ESR thus supports diagnostic investigations; however, it fails as a control parameter for the course of disease under treatment.
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PMID:[Steroid therapy and course of blood sedimentation rate in de Quervain's thyroiditis]. 811 64