Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0024312 (
lymphopenia
)
4,859
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Lymphocytes of the CD8 phenotype play an important role in controlling viral burden in HIV-1 infection. Cytotoxic CD8+ T lymphocytes (CTL) can kill HIV-infected cells and in addition, are able to secrete a soluble factor that inhibits HIV replication. In most cases, HIV-infected individuals experience an unexplained CD8+
lymphopenia
during the advanced stage of the disease that particularly affect HIV-1-specific CTL. It has been reported that CD8+ lymphocytes in HIV-infected individuals undergo programmed cell death or apoptosis. We now present a two-step model to explain CD8+ apoptosis, based on anchorage of HIV-1-associated
MHC class 1 antigen
into the envelope of extracellular viral particles.
...
PMID:Direct involvement of extracellular HIV-1 virions in the apoptosis of CD8+ lymphocytes: a two-step model. 805 70
