Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0024312 (lymphopenia)
 4,859 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Beagle dogs exposed to 238PuO2 aerosols (136 dogs, 13-22 per group, mean initial lung depositions of 0.0, 0.13, 0.68, 3.1, 13, 52 and 210 kBq) were observed throughout life to determine tissues at risk and dose-effect relationships. The pulmonary retention of 238Pu was represented by the sum of two exponentially decreasing components of the initial lung deposition; about 84% cleared with a 174-day half-time; the half-time of the remainder was 908 days. The average percentages of final body burden found in lung, skeleton, liver and thoracic lymph nodes in the 30 longest-surviving dogs (mean survival 14 years) were 1, 46, 42 and 6%, respectively. Of 116 beagles exposed to plutonium, 34 (29%) developed bone tumors, 31 (27%) developed lung tumors, and 8 (7%) developed liver tumors. Although lungs accumulated a higher average radiation dose than skeleton, more deaths were due to bone tumors than to lung tumors. Deterministic effects included radiation pneumonitis, osteodystrophy, hepatic nodular hyperplasia, lymphopenia, neutropenia and sclerosing tracheobronchial lymphadenitis. Hypoadrenocorticism was also observed in a few dogs. Increased serum alanine aminotransferase, indicative of liver damage, was observed in groups with > or =3.1 kBq initial lung deposition. Estimates of cumulative tissue dose in a human exposed to airborne 238PuO2 for 50 years at a rate of one annual limit on intake each year were derived based on a comparison of the data on metabolism for humans and beagles. The 50-year dose estimates for humans are an order of magnitude lower than doses at which increased incidence of neoplasia was observed in these dogs, whereas the projected doses to humans from 50-year exposure at the annual limit of intake are of similar magnitude to those at which deterministic effects were seen in the beagles.
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PMID:Biological effects of inhaled 238PuO2 in beagles. 933 53

During a two-year period between 1995 and 1997, over 80 blood samples were collected from pet rabbits in order to investigate an apparent osteodystrophy affecting the skulls of rabbits with acquired dental disease. A series of haematological and biochemical analyses relating to calcium metabolism were performed and samples were taken for parathyroid hormone (PTH) assay. The rabbits were categorised according to the condition of their teeth and the manner in which the pets were kept. PTH concentrations were higher and calcium concentrations lower in hutch-kept rabbits with advanced dental disease in comparison with those kept in free-range conditions. No dental problems were detected in the free-range rabbits on radiological or clinical examination. During the course of the study, differences in haematological pictures and albumin values emerged among rabbits kept under the different husbandry regimes. Complete blood counts from free-range rabbits were comparable with laboratory reference ranges, whereas there were significantly lower red cell and lymphocyte counts in rabbits exhibiting advanced dental disease. Serum albumin values were significantly higher in rabbits kept in free-range conditions than in those with advanced dental disease or those unaffected by dental disease but kept in hutches. Rabbits kept in hutches showed trends towards anaemia and lymphopenia. Results indicated that acquired dental disease of pet rabbits is related to husbandry and is associated with alterations in calcium metabolism.
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PMID:Parathyroid hormone, haematological and biochemical parameters in relation to dental disease and husbandry in rabbits. 1130 55