Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0024312 (lymphopenia)
 4,859 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Clinical data on 248 cases of pediatric Hodgkin's disease treated at the Institute within 1967-1981 were evaluated. The study was concerned with criteria for establishing individual prognosis. The prognostic value of 11 factors related to the peculiarities of tumor and host was assessed after the method of Neuman-Pearson. Such factors as stage and malignity of tumor, histological pattern, patient's age, the extent of lymph node involvement, size of conglomerates, status of mediastinal lymph nodes, intoxication, anemia and lymphopenia were found to influence long-term prognosis. Correct prognosis was made in 84,7% of the study group and in 84,0% of controls.
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PMID:[Individual prognosis in children with Hodgkin's disease]. 674 Oct 5

Laboratory tests of immunologic function were done in 96 children with Hodgkin's disease, at diagnosis and during and after treatment. Over the same period of time, 29 aged-matched control children were tested. The results presented in this report indicate that the immunology of childhood Hodgkin's disease has some features that distinguish it from the immunologic features of the disease in adults: (a) no progressive lymphopenia was found with advanced clinical stages; (b) peripheral blood T-lymphocyte counts were normal or high, and slight B lymphocytopenias were observed in children at all stages of the disease; (c) in spite of normal T-lymphocyte counts, a defective response to phytohemagglutinin stimulation was seen at diagnosis; and (d) recovery of the phytohemagglutinin response occurred with treatment and was related to modality of therapy and prognosis.
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PMID:Distinguishing features of the immunology of Hodgkin's disease in children. 707 57