Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0024312 (lymphopenia)
 4,859 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The specific features of immunological responsiveness were studied in 124 Mycobacterium tuberculosis (MBT)-infected children aged 7-14 years in relation to the ecological characteristics of their living area. All the children had early primary tuberculosis infection. The MBT-infected children were found to have first-degree secondary immunodeficiency. The latter was most pronounced in the dwellers of industrial areas, who had T-lymphocytic deficiency, the impaired supopulational composition of T cells, their diminished functional activity, an increased response to specific antigen, as well as dysimmunoglobulinemia, elevated levels of circulating immune complexes. The hyposuppressor types of cellular immunodeficiency and total T lymphopenia were observed in children living in the ecological crisis area. Superinfection and concomitant diseases create conditions for the progression of secondary immunodeficiency and for the development of severe forms of the disease.
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PMID:[Influence of environmental factors on the immunological responsiveness of Mycobacterium tuberculosis-infected children]. 1627 13

The unexpected observation of severe pulmonary tuberculosis after a 7-month combined pegylated interferon-ribavirin for chronic hepatitis C, prompted us to search an eventual immunodeficiency (lymphopenia and/or depletion of CD4+ T-lymphocytes. The retrieval of a chest radiograph incidentally performed 11 y before and showing a probable primary tuberculosis, paralleled a negligible clinical history. The enlargement of interferon indications needs careful evaluation for prior (usually missed) tuberculosis, to prevent or avoid its possible reactivation. Latent tuberculosis is increasingly reported because of extended life expectancy, immigration, and recent availability of cure for multiple chronic disorders, which are often borne by primary-secondary immunodeficiency.
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PMID:Reactivation of severe, acute pulmonary tuberculosis during treatment with pegylated interferon-alpha and ribavirin for chronic HCV hepatitis. 1650 Jul 82