Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0024312 (lymphopenia)
 4,859 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Prevention of a secondary response to factor IX by cyclophosphamide was attempted in an 11 year old patient with severe Christmas disease. An antibody to factor IX had been present for 4 years before immunosuppressive therapy was tried. Despite profound lymphopenia, synthesis of factor IX antibody was not depressed. The difficulties of modifying the anamnestic response to factor IX by chemical immunosuppression may be as real as has been reported for factor VIII in classical haemophilia.
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PMID:Failure of immunosuppression in a severe haemophilia B patient with specific antibody. 103 30

In an adolescent with hemophilia B, the diagnosis of AIDS was established in face of cachexia, orodigestive candidiasis, associated with lymphopenia, major decrease in T4/T8 ratio with marked decrease in T helper cells and presence of LAV-antibodies. The patient died rapidly from a cerebral infection due to Toxoplasma gondii. Difficulties in diagnosis and treatment of cerebral toxoplasmosis are discussed.
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PMID:[Acquired immunodeficiency syndrome in an adolescent hemophiliac]. 377 94