Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0024312 (lymphopenia)
 4,859 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 34-year-old man with no previous medical history was referred to our surgical department with abdominal pain and fever. Over the next days he developed a cluster of symptoms, which finally led us in the right diagnostical direction. On admission he had clinical findings and biochemistry supportive of cholecystitis. However, he also had a non-symptomatic rash on his chest. Intravenous antibiotic treatment was instigated. Radiological findings did not show intraabdominal pathology, except for mesenterial lymphadenopathy. After three days on antibiotics the patient still had fever. The biochemical work-up revealed persistent cholestasis, lymphopenia and increasing infectious stigmata. A more extensive laboratory work-up was performed, including bacterial, viral, and immunological tests. During the next few days the patient developed palmar erythema, polymorphic exanthema, conjunctival bleeding and a strawberry tongue. The patient gradually improved, but developed skin desquamation, thrombocytosis and reactive arthralgia. This is consistent with the clinical picture of Kawasaki disease. As all supplemental tests were negative, we could therefore conclude (based on clinical, radiological and biochemical results) that this was a rare case of adult Kawasaki disease. A review of literature describing adult Kawasaki disease is also presented.
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PMID:[A man presenting with fever and abdominal pain]. 2088 83

An adult male chinchilla (Chinchilla lanigera) presented with severe lethargy and tachypnea; the physical examination was otherwise unremarkable. Due to the animal's clinical condition, it was submitted for necropsy but died immediately prior to euthanasia. Clinicopathologic findings included leukocytosis with a left-shift neutrophilia and lymphopenia, azotemia, hyperphosphatemia, hyperglycemia, hyperlipemia, electrolyte imbalance, cholestasis, and hepatocellular damage. Neutrophilic enteritis with gramnegative bacterial colonization, hepatic lipidosis, interstitial pneumonia, suppurative tubulonephritis, erosive gastritis, cerebral edema, and lymphoid depletion were present microscopically. Attaching and effacing, eae-positive, Escherichia coli characterized by the presence of the intimin virulence factor was isolated from both the kidney and spleen. The cause of death was attributed to acute E. coli septicemia and subsequent disseminated intravascular coagulation.
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PMID:Enteric infection and subsequent septicemia due to attaching and effacing Escherichia coli in a Chinchilla. 2432 26

Background and Aims: Coronavirus disease 2019 (COVID-19) is a new respiratory infectious disease caused by severe acute respiratory syndrome coronavirus-2 (commonly known as SARS-CoV-2) with multiple organ injuries. The aim of this study was to analyze COVID-19-associated liver dysfunction (LD), its association with the risk of death and prognosis after discharge. Methods: Three-hundred and fifty-five COVID-19 patients were recruited. Clinical data were collected from electronic medical records. LD was evaluated and its prognosis was tracked. The association between LD and the risk of death was analyzed. Results: Of the 355 COVID-19 patients, 211 had mild disease, 88 had severe disease, and 51 had critically ill disease. On admission, 223 (62.8%) patients presented with hypoproteinemia, 151(42.5%) with cholestasis, and 101 (28.5%) with hepatocellular injury. As expected, LD was more common in critically ill patients. By multivariate logistic regression, male sex, older age and lymphopenia were three important independent risk factors predicting LD among COVID-19 patients. Risk of death analysis showed that the fatality rate was higher in patients with hypoproteinemia than in those without hypoproteinemia (relative risk=9.471, p<0.01). Moreover, the fatality rate was higher in patients with cholestasis than those without cholestasis (relative risk=2.182, p<0.05). Follow-up observation found that more than one hepatic functional index of two-third patients remained abnormal at 14 days after discharge. Conclusions: LD at early disease stage elevates the risk of death of COVID-19 patients. COVID-19-associated LD does not recover completely by 14 days after discharge.
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PMID:Liver Dysfunction and Its Association with the Risk of Death in COVID-19 Patients: A Prospective Cohort Study. 3308 46