Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0024312 (lymphopenia)
 4,859 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In patients with chronic calculous cholecystitis, the number of T-lymphocytes decreased, the number of B-lymphocytes and their ability to transform into the blasts in response to stimulation of the specific bacterial antigen increased, the synthesis of immunoglobulins intensified, a titre of the antibodies specific to microflora of the biliary mucosa grew, the levels of complement, lysozyme and properdin decreased, the bacterial activity of blood serum was suppressed. It is necessary to correct these disorders in the process of preoperative preparation of the patients.
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PMID:[Disordered immunologic reactivity in patients with chronic calculous cholecystitis]. 259 28

A 9-year-old spayed female Poodle was admitted because of vomiting of 3 weeks' duration, lethargy, and anorexia. Palpation of the cranial portion of the abdomen elicited signs of pain. Principal laboratory abnormalities included mild segmented neutrophilia, lymphopenia, high serum alanine aminotransferase, aspartate aminotransferase, and alkaline phosphatase activities, and hyperbilirubinemia. Radiography revealed foamy appearing areas of mineral opacity in the region of the gallbladder. Ultrasonographically, a hyperechoic structure with acoustic shadowing was seen in the same region, and extrahepatic bile ducts were distended. Cholecystectomy was performed. The gallbladder wall felt thicker than normal and was bluish-white. Multiple choleliths were found in the gallbladder and extrahepatic bile ducts. Histologic examination revealed chronic proliferative lymphoplasmacytic cholecystitis with mineralization and a well-differentiated adenocarcinoma of the gallbladder neck. A diagnosis of porcelain gallbladder was made. The dog recovered without complications and was healthy 14 months after surgery. To our knowledge, porcelain gallbladder has not been reported in dogs. In human patients, it is defined as intramural mineralization of the gallbladder commonly associated with gallbladder neoplasia. Early recognition is important for appropriate surgical treatment.
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PMID:Porcelain gallbladder associated with primary biliary adenocarcinoma in a dog. 978 80

A 34-year-old man with no previous medical history was referred to our surgical department with abdominal pain and fever. Over the next days he developed a cluster of symptoms, which finally led us in the right diagnostical direction. On admission he had clinical findings and biochemistry supportive of cholecystitis. However, he also had a non-symptomatic rash on his chest. Intravenous antibiotic treatment was instigated. Radiological findings did not show intraabdominal pathology, except for mesenterial lymphadenopathy. After three days on antibiotics the patient still had fever. The biochemical work-up revealed persistent cholestasis, lymphopenia and increasing infectious stigmata. A more extensive laboratory work-up was performed, including bacterial, viral, and immunological tests. During the next few days the patient developed palmar erythema, polymorphic exanthema, conjunctival bleeding and a strawberry tongue. The patient gradually improved, but developed skin desquamation, thrombocytosis and reactive arthralgia. This is consistent with the clinical picture of Kawasaki disease. As all supplemental tests were negative, we could therefore conclude (based on clinical, radiological and biochemical results) that this was a rare case of adult Kawasaki disease. A review of literature describing adult Kawasaki disease is also presented.
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PMID:[A man presenting with fever and abdominal pain]. 2088 83