Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0024312 (lymphopenia)
 4,859 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Fell pony foals are affected by a congenital fatal immunodeficiency that commonly leads to anaemia and lymphopenia. Previous work has shown that the foals' circulating subpopulations of CD4 and CD8 T lymphocytes are unaffected. In this study it was shown that the mean population of B lymphocytes in 10 affected foals was less than 10 per cent of that in normal foals.
Vet Rec 2003 May 17
PMID:Aid to the antemortem diagnosis of Fell pony foal syndrome by the analysis of B lymphocytes. 1279 Jan 65

Bovine lactoferrin was administered orally, in feed, to six bottlenosed dolphins (Tursiops truncatus) before they were transported for approximately six hours; their stress responses were compared with those of five untreated dolphins. During the journey the dolphins had an increased plasma concentration of cortisol, and lymphopenia, eosinopenia and mild neutrophilia, indicating a stress response. The administration of lactoferrin did not affect the function of the dolphins' polymorphonuclear leucocytes, but affected their leucogram by maintaining the number of circulating eosinophils.
Vet Rec
PMID:Effect of bovine lactoferrin on the immune responses of captive bottlenosed dolphins (Tursiops truncatus) being transported over long distances. 1718

Two warmblood horses with a history of chronic weight loss and inappetence were referred to the Faculty of Veterinary Medicine, Ludwig-Maximilians University of Munich, Germany, for further examination. The clinical signs in horse 1 were fever, tachycardia and tachypnoea, and chronic ulcerative keratopathy of both eyes. Horse 2 had severe oral ulcerations and was coughing during feeding. In both horses, increased bronchovesicular sounds were heard during auscultation of the lungs. Laboratory findings included mild anaemia, lymphopenia and hypoalbuminaemia. Radiographic examination of the thorax revealed a severe nodular interstitial pattern. Multiple nodular lesions on the surface of the lung were observed by ultrasonographic examination. Light microscopy of lung biopsy specimens obtained from horse 1 revealed a severe chronic fibrosing interstitial pneumonia. Both horses were eventually euthanased because of a poor prognosis. Postmortem examination confirmed severe multinodular fibrosing interstitial pneumonia in both horses, and lung tissue yielded positive results for equine herpesvirus type 5 DNA using PCR assay. On the basis of the clinical, radiographic and pathological findings, as well as the PCR results, the diagnosis of equine multinodular pulmonary fibrosis was established.
Vet Rec 2010 Apr 03
PMID:Clinical aspects of multinodular pulmonary fibrosis in two warmblood horses. 2036 10

Due to increasing numbers of dogs that are imported from, or have been visiting Mediterranean countries, canine leishmaniasis has become a very important infectious disease in Germany. The aim of this study was to determine which laboratory and clinical parameters can be used as prognostic factors, whether level of antibody titre is a prognostic factor, and whether treatment leads to a better prognosis in a country in which reinfection is extremely unlikely. Data of 72 dogs infected with Leishmania infantum that had been presented to the Clinic of Small Animal Medicine of the LMU University of Munich, Germany, and whose owners answered a detailed questionnaire, were reviewed retrospectively. All dogs included in the study had clinical signs compatible with canine leishmaniasis. No correlation between the level of antibody titres (carried out by immunofluorescence assay) and survival time was found (p = 0.982). However, there was a significant correlation between survival time and presence of proteinuria (p < 0.001), hypoalbuminemia (p = 0.002), and lymphopenia (p = 0.040) in all treated dogs. Furthermore, treatment of diseased dogs resulted in a longer survival time (p = 0.003). In conclusion, levels of antibody titres did not correlate with prognosis. More useful parameters to predict shorter survival were proteinuria, hypoalbuminemia and lymphopenia. Also, treatment was correlated with a longer survival of almost two years.
Vet Rec 2012 Oct 20
PMID:Prognostic analytes in dogs with Leishmania infantum infection living in a non-endemic area. 2291 80


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