Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0024141 (systemic lupus erythematosus)
 44,322 document(s) hit in 31,850,051 MEDLINE articles (0.02 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
Sep 2636
cytokine 1462
She 1234
Mol 926
CD4 905
interferon 740
IgA 728
IFN 721
glycoprotein 714
collagen 678
prothrombin 605
HLA 591
IL-6 578
lymphoid 576
thromboplastin 558
TNF 554
SSA 543
RNP 508
rheumatoid factor 500
autoantigen 488
histone 475
IL-10 466
ANA 438
CD8 397
ankylosing spondylitis 396
Fas 393
C-reactive protein 374
tumor necrosis factor 372
thymus 367
beta2-glycoprotein I 355
SSB 354
protein C 328
IL-2 316
SS-A 295
ACR 292
protein S 288
insulin 287
BAFF 271
MRI 266
IFN-gamma 266
IL-17 264
ribonucleoprotein 262
IL-4 261
TLR7 252
TLR9 236
CD20 233
type I interferon 232
thrombin 224
MHC 223
SS-B 222
TNF-alpha 222
albumin 221
serum albumin 213
major histocompatibility complex 213
fibrinogen 199
lipopolysaccharide 197
B lymphocyte stimulator 194
IgG3 190
TCR 179
chemokine 175
dilute 172
CD25 170
polypeptide 167
myeloperoxidase 165
factor VIII 163
CD40 162
LPS 157
T cell receptor 157
IL-1 156
GPI 155
APS 155
prolactin 152
ESR 152
interleukin-6 152
HLA-DR 150
Pol 148
CD40L 148
factor V Leiden 147
DR3 142
Cytokine 142
CRP 141
heavy chain 135
CD28 133
interleukin-2 133
hemoglobin 131
antithrombin III 131
chronic renal failure 130
IgE 126
interferon-gamma 125
MHC class II 124
CD19 123
antithrombin 122
gut 122
lectin 111
ARA 111
CR1 111
von Willebrand factor 110
C4A 109
Ro52 107
factor V 106
Fc receptor 104
IL-21 102
CD86 102
U1-70K 100
IL-8 100
DNase 100
CD45 99
non-Hodgkin's lymphoma 99
annexin V 98
BCR 98
DBA 97
IL-18 96
TLR4 95
H2B 95
kit 93
small nuclear ribonucleoprotein 93
interferon-alpha 93
B19 89
Mal 88
CSF 87
ENA 87
H2A 87
class V 87
tissue factor 83
fibronectin 82
HLA-DR3 81
ICAM-1 79
SDS 79
plasminogen 78
ferritin 78
Ro60 77
CD22 77
membrane-bound 77
CD80 75
TGF-beta 75
Bcl-2 75
Fc gamma 75
human leukocyte antigen 75
CD5 75
P protein 74
C4B 73
granulocyte 73
mucin 72
IL-23 72
MCP-1 72
APC 72
proteinase 3 72
Fas ligand 71
PHA 71
peroxidase 71
alkaline phosphatase 70
HDL 70
MAPK 70
endoplasmic reticulum 70
IRF5 69
CD40 ligand 69
HLA-DRB1 69
ATP 69
CTLA-4 69
interleukin-10 68
more...
Disease
systemic lupus erythematosus 44322
lupus 20554
lupus 14981
Lupus 6889
rheumatoid arthritis 5290
autoimmune disease 4502
SLE 4409
lupus nephritis 3143
antiphospholipid syndrome 2503
arthritis 2430
vasculitis 2120
glomerulonephritis 1852
proteinuria 1567
renal disease 1546
PSS 1500
thrombocytopenia 1434
nephritis 1379
cancer 1284
hypertension 1085
multiple sclerosis 1079
diabetes 917
scleroderma 875
rash 834
dermatomyositis 796
atherosclerosis 790
mixed connective tissue disease 714
connective tissue disease 636
psoriasis 598
renal failure 563
nephrotic syndrome 556
polymyositis 549
anemia 525
lymphadenopathy 507
tuberculosis 503
stroke 497
tumor 478
lymphoma 415
HIV 414
ankylosing spondylitis 411
Sjogren's syndrome 404
infectious diseases 387
cardiovascular disease 386
Raynaud's phenomenon 386
hemolytic anemia 384
type 1 diabetes 384
hepatitis 381
pneumonia 381
abortion 373
depression 365
Crohn's disease 359
immunodeficiency 359
sarcoidosis 343
photosensitivity 338
inflammatory bowel disease 332
preeclampsia 315
sepsis 306
systemic disease 305
thrombocytopenic purpura 303
Wegener's granulomatosis 301
pulmonary hypertension 301
leukopenia 289
Epstein 284
heart block 282
myasthenia gravis 279
membranous nephropathy 274
osteoarthritis 273
pericarditis 272
psoriatic arthritis 266
myocardial infarction 264
sepsis 264
asthma 258
deep vein thrombosis 253
myositis 249
syphilis 247
psychosis 245
skin disease 240
virus infection 239
rheumatism 237
plaque 235
purpura 234
vascular disease 233
osteoporosis 232
polyarthritis 230
AIDS 227
lymphopenia 223
polyarteritis nodosa 222
juvenile rheumatoid arthritis 219
chronic renal failure 217
cognitive impairment 214
idiopathic thrombocytopenic purpura 209
myocarditis 208
Graves' disease 207
pancytopenia 206
dermatitis 205
Infection 201
primary biliary cirrhosis 198
ulcerative colitis 198
ischemia 197
cytomegalovirus 194
graft-versus-host disease 193
glomerulosclerosis 192
heart failure 187
IgA nephropathy 183
cold 181
leukemia 179
autoimmune hemolytic anemia 179
multiple myeloma 178
myelitis 178
Hashimoto's thyroiditis 174
Raynaud 173
coronary artery disease 172
Best 171
pericardial effusion 170
endocarditis 169
pulmonary embolism 165
neuropathy 165
Mycobacterium 165
renal insufficiency 164
Hodgkin's disease 164
cryoglobulinemia 163
PGA 160
pemphigus 158
celiac disease 155
panniculitis 155
hypergammaglobulinemia 154
liver disease 153
obesity 153
interstitial lung disease 151
encephalomyelitis 147
fibromyalgia 146
gout 145
amyloidosis 140
neutropenia 138
encephalopathy 138
confusion 137
atopic dermatitis 137
hypothyroidism 137
lymphadenitis 136
epilepsy 136
arthropathy 136
migraine 135
hepatitis B 134
chronic disease 133
thyroiditis 133
urticaria 133
uveitis 130
mimicry 129
pemphigoid 128
cirrhosis 128
peritonitis 127
parvovirus 126
hepatitis C 123
acute renal failure 122
disseminated intravascular coagulation 120
encephalitis 120
carcinoma 118
Alzheimer's disease 117
myopathy 116
Behcet's disease 116
pancreatitis 116
more...
Symptom
pain 452
arthralgia 399
seizures 384
headache 381
fatigue 360
abdominal pain 279
erythema 277
dyspnea 249
weakness 230
splenomegaly 226
livedo 198
diarrhea 166
chorea 152
vomiting 152
myalgia 129
nausea 117
chest pain 112
cough 101
Ill 82
hepatosplenomegaly 71
hemoptysis 66
collapse 61
angina 60
shortness of breath 59
respiratory distress 58
regurgitation 58
fever of unknown origin 46
anesthesia 44
dry eye 41
hepatomegaly 41
anorexia 40
numbness 39
back pain 39
ataxia 38
acute abdomen 37
exertional dyspnea 37
dizziness 35
chills 30
asthenia 30
vertigo 29
acute abdominal pain 29
paraparesis 27
hemiplegia 27
paresis 26
paresthesia 26
pleuritic chest pain 26
cerebellar ataxia 24
low back pain 24
discomfort 24
blurred vision 23
night sweats 23
dysarthria 23
sleepiness 22
discomfort 22
epigastric pain 22
hoarseness 21
Flare 21
thinning 21
catatonia 20
exhaustion 20
lethargy 19
insomnia 19
pallor 18
tonic-clonic seizure 18
tense 17
tremor 17
syncope 17
cachexia 17
overweight 17
nausea and vomiting 17
dysuria 16
memory loss 16
sore throat 15
oliguria 15
Urticarial vasculitis 14
spasm 14
constipation 14
hypoproteinemia 14
functional recovery 13
orthopnea 13
cyanosis 13
hip pain 13
dystonia 13
consciousness disturbance 13
periorbital edema 13
Gastrointestinal symptoms 12
swollen joints 12
spasticity 12
leg edema 12
knee pain 11
flushing 11
agitation 11
starvation 11
skin damage 11
tachypnea 10
productive cough 10
tinnitus 10
myoclonus 10
polyuria 10
ophthalmoplegia 10
flank pain 9
Cushingoid 9
Cushingoid 9
polymyalgia 9
bradykinesia 8
tingling 8
urinary frequency 8
neck pain 8
groin pain 8
hypothermia 8
HSA 8
SLE-like symptoms 8
analgesia 8
photophobia 7
sciatica 7
pedal edema 6
Psychiatric symptoms 6
leg pain 6
alexithymia 5
heartburn 5
apathy 5
acute stress 5
polydipsia 5
dysesthesia 5
abdominal discomfort 5
clubbing 4
Depressive symptoms 4
rales 4
ataxic gait 4
shoulder pain 4
skin impairment 4
intestinal bleeding 4
generalized pain 4
colic 4
Murphy's sign 4
gumma 4
stridor 4
Livedoid 4
chest tightness 4
abnormal gait 3
forgetfulness 3
twitching 3
chronic cough 3
wrist pain 3
lightheadedness 3
Skin symptoms 3
muscle stiffness 3
Physical findings 3
hyperemesis gravidarum 3
bone pain 3
meningism 3
partial seizure 3
emaciation 3
muscle cramps 3
personality change 3
Musculoskeletal symptoms 3
testicular pain 3
Diaphragmatic weakness 3
acute pain 3
Neurologic symptoms 3
more...
Drug
Dermatol 1248
IL-2 317
IFN-gamma 257
Rituximab 155
CSF 128
CTX 108
Cardiovasc 99
Nephron 90
Dial 81
lysine 81
Belimumab 80
Nephron 70
BLyS 65
DNase I 57
Prednisolone 54
ROC 51
Prednisone 39
Methylprednisolone 37
Asthma 36
Estrogens 32
Infliximab 31
Infliximab 31
ROS 30
Gel 28
Monit 26
Tacrolimus 23
MAP 22
IFN-beta 21
Kaolin 21
EE2 19
Epratuzumab 18
G-CSF 18
ampicillin 17
p75 16
vitamin E 15
ENT 15
Fluorescein 14
Fluorescein 14
Tocilizumab 14
Isoniazid 13
ABC 13
CTX 13
CTX 13
Abatacept 13
Adalimumab 12
Silica 12
IL-1ra 11
Alliance 11
ascorbate 11
Bortezomib 11
Nitric Oxide 10
Mycophenolic acid 10
TAT 10
Bifidobacterium 9
Vitamin B12 9
Eculizumab 9
Serum albumin 9
Albumin 9
Leaf 9
EPA 9
nitroglycerin 9
Captopril 8
Plaquenil 8
Plaquenil 8
THF 8
Dakar 8
Asn 8
Indomethacin 7
PCB 7
Vitamin K 7
Lovastatin 7
Hypaque 6
ETS 6
CAM 6
LMWH 6
NAG 6
Anakinra 6
CCL 6
Biopolymers 6
BLM 6
Fragment 6
Spectrum 6
PFA 5
Hypaque 5
PDL 5
Phosphatidylserine 5
Glutathione 5
lactose 5
CaCl2 5
Adenosine deaminase 5
Ancrod 5
caffeine 5
Retinoic acid 5
MDS 5
Award 5
PTH 5
CaCl2 5
CaCl2 5
Angiotensin II 5
Fraction 5
Sulphasalazine 5
MRC 4
niacin 4
PTC 4
uPA 4
Orphan 4
DM1 4
CIA 4
SiO2 4
Ganciclovir 4
Portal 4
Acyclovir 4
EPI 4
CDP 4
Spectrum 4
Alanine 4
Dalteparin 3
Mizoribine 3
Phenytoin 3
Abetimus sodium 3
Imiquimod 3
CFS 3
AGG 3
ADM 3
HCG 3
Gastro 3
IL-11 3
Zoledronic acid 3
Itraconazole 3
ALA 3
Bayer 3
Bosentan 3
Zoledronic acid 3
BCG vaccine 3
THA 3
Copaxone 3
Bosentan 3
Antithrombin III 3
ICI 3
Paraffin 3
Imuran 3
Vitamin A 3
CVA 3
Frentizole 3
Cellcept 2
Edratide 2
Camp 2
Arsenic trioxide 2
Teriparatide 2
Olive oil 2
Argatroban 2
Cellcept 2
NBT 2
Clodronate 2
Fosamax 2
APD 2
IPM 2
Simvastatin 2
Isoprinosine 2
Quinine, 2
more...
Enzyme
thromboplastin 596
APC 452
peroxidase 235
thrombin 217
mitogen-activated protein kinase 153
DNase 141
focal adhesion kinase 134
ERK 117
RNase 92
RNase 84
RNA polymerase 79
calcineurin 78
protein kinase 74
alkaline phosphatase 71
tissue plasminogen activator 68
proteasome 61
trypsin 60
superoxide dismutase 53
renin 53
reverse transcriptase 47
caspase-3 46
catalase 46
alanine aminotransferase 46
luciferase 44
creatine kinase 43
ACE 43
protein kinase C 41
lactate dehydrogenase 37
methylenetetrahydrofolate reductase 34
methylenetetrahydrofolate reductase 34
thyroid peroxidase 32
endonuclease 32
aspartate aminotransferase 32
C3 convertase 31
lysozyme 31
caspase-1 30
plasmin 28
elastase 28
ribonuclease 27
ribonuclease 27
urokinase-type plasminogen activator 26
CDR 26
DNA methyltransferase 25
NADPH oxidase 25
pepsin 25
kallikrein 25
glutathione peroxidase 25
NADPH oxidase 25
neuraminidase 24
ATPase 24
granzyme B 24
collagenase 22
IKK 22
lipase 21
C3 convertase 21
deoxyribonuclease 20
deoxyribonuclease 20
glutathione S-transferase 19
transglutaminase 18
ceruloplasmin 18
PARP 18
phospholipase A2 18
peptidylarginine deiminase 18
transcriptase 18
topoisomerase 18
topoisomerase 17
P-glycoprotein 17
DNA polymerase 17
enolase 16
AST 16
gamma-glutamyl transpeptidase 16
paraoxonase 16
S1 nuclease 16
beta-galactosidase 15
caspase-8 15
MEK 15
CAD 14
ACS 14
CAD 14
paraoxonase 14
CAD 14
AMP-activated protein kinase 14
proteinase-3 14
MAP 14
pyruvate dehydrogenase 13
p100 13
GP-I 12
p80 12
CD10 12
factor D 12
PAH 12
AMPK 12
MIP 12
phosphodiesterase 12
neutrophil elastase 12
adenosine deaminase 11
adenosine deaminase 11
MMP 10
TAT 10
BMT 10
acetylcholinesterase 10
MMP-3 9
cathepsin G 9
aldolase 9
ornithine decarboxylase 9
protein phosphatase 2A 9
ancrod 9
acid phosphatase 9
beta-glucuronidase 9
pyruvate dehydrogenase 8
AMPK 8
indoleamine 2,3-dioxygenase 8
IMP dehydrogenase 8
Thy1 8
C3b inactivator 8
NO synthase 8
phosphatidylinositol 3-kinase 8
thiopurine methyltransferase 8
glyceraldehyde-3-phosphate dehydrogenase 8
N-acetyltransferase 8
pyruvate dehydrogenase 8
prostaglandin synthetase 7
lipoxygenase 7
21-hydroxylase 7
DNase II 7
phosphoinositide 3-kinase 7
CEP 7
papain 7
phospholipase C 7
CEP 7
caspase-9 7
cholinesterase 7
TSP-1 7
BAL 7
GSK 6
ATP synthase 6
heme oxygenase 6
tryptase 6
DAT 6
lipoprotein lipase 6
MCS 6
aldehyde dehydrogenase 6
sialidase 6
tissue kallikrein 6
bromelain 6
histidyl-tRNA synthetase 5
E-2 5
peroxiredoxin 5
prolidase 5
TdT 5
arginine deiminase 5
STR 5
glutathione reductase 5
histone acetyltransferase 5
glyceraldehyde-3-phosphate dehydrogenase 4
carbonic anhydrase 4
cdc2 4
chymotrypsin 4
mannosidase II 4
guanylate cyclase 4
more...
Compound
Clin 6088
DNA 5315
Dec 2925
creatinine 598
TNF 554
ANA 440
ANA 440
calcium 389
oxygen 297
vitamin D 194
sulfate 192
Cardiol 191
arginine 177
water 174
sodium 173
phosphate 169
ANCA 166
glucose 160
His 159
acetate 157
tyrosine 157
APS 155
Hydroxychloroquine 144
urea 142
nitrogen 131
PEG 126
CTX 108
serine 103
lysine 102
nitric oxide 101
BCR 98
DBA 97
DBA 97
DBA 97
salt 93
SDS 84
homocysteine 82
iron 81
Dial 81
Mycophenolate mofetil 75
leucine 72
potassium 69
ATP 69
prostacyclin 69
hydrogen 62
EDTA 61
EDTA 61
Estrogen 61
ADP 56
Prednisolone 53
Vitamin D 53
zinc 53
ammonium 52
PEG 51
CCP 50
CO2 50
Estrogen 49
A 42 49
Asp 49
Cyclosporine 48
threonine 47
iodine 46
Pac 45
PMA 45
Optimal 44
ITP 44
Azathioprine 43
tryptophan 43
ADP 42
ADP 42
alanine 42
Phe 41
PMA 41
mercury 41
Hydralazine 40
tryptophan 40
Pristane 40
tryptophan 40
tryptophan 40
ASA 40
methionine 39
galactose 39
Prednisone 39
NKT 38
ethanol 38
DHA 38
Chloroquine 37
Methotrexate 37
Chloroquine 37
cAMP 37
Methylprednisolone 36
Heparin 35
Gly 35
ADP-ribose 35
INH 34
FK506 34
TSH 34
Warfarin 33
GSH 31
TOF 31
AMP 31
bromide 31
GSH 31
neopterin 30
copper 30
Procainamide 29
cysteine 29
glycerol 27
glutamate 27
Guo 27
Collagen 27
Retinal 27
hydroxylamine 26
hydroxylamine 26
DEAE 26
cGMP 26
retinoic acid 26
pyrimidine 25
pyrimidine 25
Thyroid 25
Histone 25
prostaglandin E1 25
silver 25
Interleukin-2 25
Guo 25
Neo 24
NH2 24
aldosterone 24
H2O2 24
Thrombin 23
Isoproterenol 23
silicon 23
BCG 22
ACTH 22
acetone 22
DNP 22
6-12 22
hydroxide 21
PAPS 21
PGE 20
NMDA 19
PGE2 19
THP 19
Minocycline 19
proline 18
hyaluronic acid 18
GM1 18
THP 18
Congo red 18
glutamine 17
DPA 17
nitrate 17
DPA 17
MAP 17
acrylamide 17
Ile 17
PAS 17
phosphorus 17
barium 17
DTPA 17
more...